The Role of DNA Damage and Repair in Idiopathic Pulmonary Fibrosis
The mortality rate of idiopathic pulmonary fibrosis (IPF) increases yearly due to ineffective treatment. Given that the lung is exposed to the external environment, it is likely that oxidative stress, especially the stimulation of DNA, would be of particular importance in pulmonary fibrosis. DNA dam...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/11/2292 |
| _version_ | 1797466036345241600 |
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| author | Jiahui Zhu Lexin Liu Xiaodi Ma Xinyu Cao Yu Chen Xiangping Qu Ming Ji Huijun Liu Chi Liu Xiaoqun Qin Yang Xiang |
| author_facet | Jiahui Zhu Lexin Liu Xiaodi Ma Xinyu Cao Yu Chen Xiangping Qu Ming Ji Huijun Liu Chi Liu Xiaoqun Qin Yang Xiang |
| author_sort | Jiahui Zhu |
| collection | DOAJ |
| description | The mortality rate of idiopathic pulmonary fibrosis (IPF) increases yearly due to ineffective treatment. Given that the lung is exposed to the external environment, it is likely that oxidative stress, especially the stimulation of DNA, would be of particular importance in pulmonary fibrosis. DNA damage is known to play an important role in idiopathic pulmonary fibrosis initiation, so DNA repair systems targeting damage are also crucial for the survival of lung cells. Although many contemporary reports have summarized the role of individual DNA damage and repair pathways in their hypotheses, they have not focused on idiopathic pulmonary fibrosis. This review, therefore, aims to provide a concise overview for researchers to understand the pathways of DNA damage and repair and their roles in IPF. |
| first_indexed | 2024-03-09T18:30:17Z |
| format | Article |
| id | doaj.art-6256d5484ce04b479a03884a39baab74 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T18:30:17Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-6256d5484ce04b479a03884a39baab742023-11-24T07:32:51ZengMDPI AGAntioxidants2076-39212022-11-011111229210.3390/antiox11112292The Role of DNA Damage and Repair in Idiopathic Pulmonary FibrosisJiahui Zhu0Lexin Liu1Xiaodi Ma2Xinyu Cao3Yu Chen4Xiangping Qu5Ming Ji6Huijun Liu7Chi Liu8Xiaoqun Qin9Yang Xiang10School of Basic Medicine, Central South University, Changsha 410000, ChinaSchool of Basic Medicine, Central South University, Changsha 410000, ChinaSchool of Basic Medicine, Central South University, Changsha 410000, ChinaSchool of Basic Medicine, Central South University, Changsha 410000, ChinaDepartment of Medical Laboratory, School of Medicine, Hunan Normal University, Changsha 410000, ChinaSchool of Basic Medicine, Central South University, Changsha 410000, ChinaSchool of Basic Medicine, Central South University, Changsha 410000, ChinaSchool of Basic Medicine, Central South University, Changsha 410000, ChinaSchool of Basic Medicine, Central South University, Changsha 410000, ChinaSchool of Basic Medicine, Central South University, Changsha 410000, ChinaSchool of Basic Medicine, Central South University, Changsha 410000, ChinaThe mortality rate of idiopathic pulmonary fibrosis (IPF) increases yearly due to ineffective treatment. Given that the lung is exposed to the external environment, it is likely that oxidative stress, especially the stimulation of DNA, would be of particular importance in pulmonary fibrosis. DNA damage is known to play an important role in idiopathic pulmonary fibrosis initiation, so DNA repair systems targeting damage are also crucial for the survival of lung cells. Although many contemporary reports have summarized the role of individual DNA damage and repair pathways in their hypotheses, they have not focused on idiopathic pulmonary fibrosis. This review, therefore, aims to provide a concise overview for researchers to understand the pathways of DNA damage and repair and their roles in IPF.https://www.mdpi.com/2076-3921/11/11/2292DNA damageDNA repairidiopathic pulmonary fibrosisbase excision repairnucleotide excision repairmismatch repair |
| spellingShingle | Jiahui Zhu Lexin Liu Xiaodi Ma Xinyu Cao Yu Chen Xiangping Qu Ming Ji Huijun Liu Chi Liu Xiaoqun Qin Yang Xiang The Role of DNA Damage and Repair in Idiopathic Pulmonary Fibrosis Antioxidants DNA damage DNA repair idiopathic pulmonary fibrosis base excision repair nucleotide excision repair mismatch repair |
| title | The Role of DNA Damage and Repair in Idiopathic Pulmonary Fibrosis |
| title_full | The Role of DNA Damage and Repair in Idiopathic Pulmonary Fibrosis |
| title_fullStr | The Role of DNA Damage and Repair in Idiopathic Pulmonary Fibrosis |
| title_full_unstemmed | The Role of DNA Damage and Repair in Idiopathic Pulmonary Fibrosis |
| title_short | The Role of DNA Damage and Repair in Idiopathic Pulmonary Fibrosis |
| title_sort | role of dna damage and repair in idiopathic pulmonary fibrosis |
| topic | DNA damage DNA repair idiopathic pulmonary fibrosis base excision repair nucleotide excision repair mismatch repair |
| url | https://www.mdpi.com/2076-3921/11/11/2292 |
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