Three Distinct Sets of Connector Hubs Integrate Human Brain Function
Summary: Control over behavior is enabled by the brain’s control networks, which interact with lower-level sensory motor and default networks to regulate their functions. Such interactions are facilitated by specialized “connector hub” regions that interconnect discrete networks. Previous work has t...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-08-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124718311537 |
| _version_ | 1818355884796936192 |
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| author | Evan M. Gordon Charles J. Lynch Caterina Gratton Timothy O. Laumann Adrian W. Gilmore Deanna J. Greene Mario Ortega Annie L. Nguyen Bradley L. Schlaggar Steven E. Petersen Nico U.F. Dosenbach Steven M. Nelson |
| author_facet | Evan M. Gordon Charles J. Lynch Caterina Gratton Timothy O. Laumann Adrian W. Gilmore Deanna J. Greene Mario Ortega Annie L. Nguyen Bradley L. Schlaggar Steven E. Petersen Nico U.F. Dosenbach Steven M. Nelson |
| author_sort | Evan M. Gordon |
| collection | DOAJ |
| description | Summary: Control over behavior is enabled by the brain’s control networks, which interact with lower-level sensory motor and default networks to regulate their functions. Such interactions are facilitated by specialized “connector hub” regions that interconnect discrete networks. Previous work has treated hubs as a single category of brain regions, although their unitary nature is dubious when examined in individual brains. Here we investigated the nature of hubs by using fMRI to characterize individual-specific hub regions in two independent datasets. We identified three separable sets of connector hubs that integrate information between specific brain networks. These three hub categories occupy different positions within the brain’s network structure; they affect networks differently when artificially lesioned, and they are differentially engaged during cognitive and motor task performance. This work suggests a model of brain organization in which different connector hubs integrate control functions and enable top-down control of separate processing streams. : Gordon et al. identify separable control-processing, control-default, and cross-control connector hubs that integrate specific brain networks. These hub sets are differentially engaged during task performance and affect networks differently when artificially lesioned. Different connector hub sets may separately enable top-down control of sensory motor, emotional, and control of control functions. Keywords: fMRI, functional connectivity, brain networks, connector hubs |
| first_indexed | 2024-12-13T19:48:25Z |
| format | Article |
| id | doaj.art-62573959934742239c1a691a8012b7ef |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-13T19:48:25Z |
| publishDate | 2018-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-62573959934742239c1a691a8012b7ef2022-12-21T23:33:29ZengElsevierCell Reports2211-12472018-08-0124716871695.e4Three Distinct Sets of Connector Hubs Integrate Human Brain FunctionEvan M. Gordon0Charles J. Lynch1Caterina Gratton2Timothy O. Laumann3Adrian W. Gilmore4Deanna J. Greene5Mario Ortega6Annie L. Nguyen7Bradley L. Schlaggar8Steven E. Petersen9Nico U.F. Dosenbach10Steven M. Nelson11VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, TX 76711, USA; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX 75235, USA; Department of Psychology and Neuroscience, Baylor University, Waco, TX 76789, USA; Corresponding authorDepartment of Psychology, Georgetown University, Washington, DC 20057, USA; Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY 10065, USADepartment of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USADepartment of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USADepartment of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO 63110, USA; Laboratory of Brain and Cognition, National Institute of Mental Health, NIH, Bethesda, MD 20892, USADepartment of Radiology, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO 63110, USADepartment of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USADepartment of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USADepartment of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Radiology, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Neuroscience, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Pediatrics, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO 63110, USADepartment of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Radiology, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Neuroscience, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63110, USADepartment of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Occupational Therapy, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Pediatrics, Washington University in St. Louis, St. Louis, MO 63110, USAVISN 17 Center of Excellence for Research on Returning War Veterans, Waco, TX 76711, USA; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX 75235, USA; Department of Psychology and Neuroscience, Baylor University, Waco, TX 76789, USASummary: Control over behavior is enabled by the brain’s control networks, which interact with lower-level sensory motor and default networks to regulate their functions. Such interactions are facilitated by specialized “connector hub” regions that interconnect discrete networks. Previous work has treated hubs as a single category of brain regions, although their unitary nature is dubious when examined in individual brains. Here we investigated the nature of hubs by using fMRI to characterize individual-specific hub regions in two independent datasets. We identified three separable sets of connector hubs that integrate information between specific brain networks. These three hub categories occupy different positions within the brain’s network structure; they affect networks differently when artificially lesioned, and they are differentially engaged during cognitive and motor task performance. This work suggests a model of brain organization in which different connector hubs integrate control functions and enable top-down control of separate processing streams. : Gordon et al. identify separable control-processing, control-default, and cross-control connector hubs that integrate specific brain networks. These hub sets are differentially engaged during task performance and affect networks differently when artificially lesioned. Different connector hub sets may separately enable top-down control of sensory motor, emotional, and control of control functions. Keywords: fMRI, functional connectivity, brain networks, connector hubshttp://www.sciencedirect.com/science/article/pii/S2211124718311537 |
| spellingShingle | Evan M. Gordon Charles J. Lynch Caterina Gratton Timothy O. Laumann Adrian W. Gilmore Deanna J. Greene Mario Ortega Annie L. Nguyen Bradley L. Schlaggar Steven E. Petersen Nico U.F. Dosenbach Steven M. Nelson Three Distinct Sets of Connector Hubs Integrate Human Brain Function Cell Reports |
| title | Three Distinct Sets of Connector Hubs Integrate Human Brain Function |
| title_full | Three Distinct Sets of Connector Hubs Integrate Human Brain Function |
| title_fullStr | Three Distinct Sets of Connector Hubs Integrate Human Brain Function |
| title_full_unstemmed | Three Distinct Sets of Connector Hubs Integrate Human Brain Function |
| title_short | Three Distinct Sets of Connector Hubs Integrate Human Brain Function |
| title_sort | three distinct sets of connector hubs integrate human brain function |
| url | http://www.sciencedirect.com/science/article/pii/S2211124718311537 |
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