The Phenotypic Characterization of the Oldest Italian Man from December 28, 2020, to September 23, 2021, A.T., Strengthens the Idea That the Immune System can Play a Key Role in the Attainment of Extreme Longevity
In this paper, we present demographic, clinical, anamnestic, cognitive, and functional data, as well as haematological, haematochemical, immunological, and genetic parameters of an exceptional individual: A.T., a semi-supercentenarian who held the title of the oldest living Italian male centenarian...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/24/7591 |
| _version_ | 1797380546012119040 |
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| author | Giulia Accardi Anna Aiello Stefano Aprile Anna Calabrò Rosalia Caldarella Calogero Caruso Marcello Ciaccio Francesco Dieli Mattia Emanuela Ligotti Serena Meraviglia Giuseppina Candore |
| author_facet | Giulia Accardi Anna Aiello Stefano Aprile Anna Calabrò Rosalia Caldarella Calogero Caruso Marcello Ciaccio Francesco Dieli Mattia Emanuela Ligotti Serena Meraviglia Giuseppina Candore |
| author_sort | Giulia Accardi |
| collection | DOAJ |
| description | In this paper, we present demographic, clinical, anamnestic, cognitive, and functional data, as well as haematological, haematochemical, immunological, and genetic parameters of an exceptional individual: A.T., a semi-supercentenarian who held the title of the oldest living Italian male centenarian from 28 December 2020, to 23 September 2021. The purpose of this study is to provide fresh insights into extreme phenotypes, with a particular focus on immune-inflammatory parameters. To the best of our knowledge, this study represents the first phenotypic investigation of a semi-supercentenarian, illustrating both INFLA-score, a metric designed to assess the cumulative impact of inflammatory markers and indicators of age-related immune phenotype (ARIP), recognized as significant gauges of biological ageing. The aim of this study was, indeed, to advance our understanding of the role of immune-inflammatory responses in achieving extreme longevity. The results of laboratory tests, as well as clinical history and interview data, when compared to the results of our recent study on Sicilian centenarians, demonstrate an excellent state of health considering his age. Consistent with previous studies, we observed increased IL-6 inflammatory markers and INFLA score in A.T. More interestingly, the semi-supercentenarian showed values of ARIP indicators such as naïve CD4+ cells, CD4+/CD8+ ratio, and CD4+TN/TM ratio in the range of young adult individuals, suggesting that his immune system’s biological age was younger than the chronological one. The results support the notion that the immune system can play a role in promoting extreme longevity. However, this does not rule out the involvement of other body systems or organs in achieving extreme longevity. |
| first_indexed | 2024-03-08T20:38:50Z |
| format | Article |
| id | doaj.art-62581924d2ab40edafa3062ad2554538 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-08T20:38:50Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-62581924d2ab40edafa3062ad25545382023-12-22T14:17:06ZengMDPI AGJournal of Clinical Medicine2077-03832023-12-011224759110.3390/jcm12247591The Phenotypic Characterization of the Oldest Italian Man from December 28, 2020, to September 23, 2021, A.T., Strengthens the Idea That the Immune System can Play a Key Role in the Attainment of Extreme LongevityGiulia Accardi0Anna Aiello1Stefano Aprile2Anna Calabrò3Rosalia Caldarella4Calogero Caruso5Marcello Ciaccio6Francesco Dieli7Mattia Emanuela Ligotti8Serena Meraviglia9Giuseppina Candore10Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, 90133 Palermo, ItalyLaboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, 90133 Palermo, ItalyUnit of Transfusion Medicine, San Giovanni di Dio Hospital, 92100 Agrigento, ItalyLaboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, 90133 Palermo, ItalyDepartment of Laboratory medicine, University Hospital “P. Giaccone”, 90127 Palermo, ItalyLaboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, 90133 Palermo, ItalyDepartment of Laboratory medicine, University Hospital “P. Giaccone”, 90127 Palermo, ItalyCentral Laboratory of Advanced Diagnosis and Biomedical Research, University Hospital “P. Giaccone”, 90127 Palermo, ItalyLaboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, 90133 Palermo, ItalyCentral Laboratory of Advanced Diagnosis and Biomedical Research, University Hospital “P. Giaccone”, 90127 Palermo, ItalyLaboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, 90133 Palermo, ItalyIn this paper, we present demographic, clinical, anamnestic, cognitive, and functional data, as well as haematological, haematochemical, immunological, and genetic parameters of an exceptional individual: A.T., a semi-supercentenarian who held the title of the oldest living Italian male centenarian from 28 December 2020, to 23 September 2021. The purpose of this study is to provide fresh insights into extreme phenotypes, with a particular focus on immune-inflammatory parameters. To the best of our knowledge, this study represents the first phenotypic investigation of a semi-supercentenarian, illustrating both INFLA-score, a metric designed to assess the cumulative impact of inflammatory markers and indicators of age-related immune phenotype (ARIP), recognized as significant gauges of biological ageing. The aim of this study was, indeed, to advance our understanding of the role of immune-inflammatory responses in achieving extreme longevity. The results of laboratory tests, as well as clinical history and interview data, when compared to the results of our recent study on Sicilian centenarians, demonstrate an excellent state of health considering his age. Consistent with previous studies, we observed increased IL-6 inflammatory markers and INFLA score in A.T. More interestingly, the semi-supercentenarian showed values of ARIP indicators such as naïve CD4+ cells, CD4+/CD8+ ratio, and CD4+TN/TM ratio in the range of young adult individuals, suggesting that his immune system’s biological age was younger than the chronological one. The results support the notion that the immune system can play a role in promoting extreme longevity. However, this does not rule out the involvement of other body systems or organs in achieving extreme longevity.https://www.mdpi.com/2077-0383/12/24/7591ageingARIPbiological ageinginflamm-ageingINFLA scorelymphocyte subsets |
| spellingShingle | Giulia Accardi Anna Aiello Stefano Aprile Anna Calabrò Rosalia Caldarella Calogero Caruso Marcello Ciaccio Francesco Dieli Mattia Emanuela Ligotti Serena Meraviglia Giuseppina Candore The Phenotypic Characterization of the Oldest Italian Man from December 28, 2020, to September 23, 2021, A.T., Strengthens the Idea That the Immune System can Play a Key Role in the Attainment of Extreme Longevity Journal of Clinical Medicine ageing ARIP biological ageing inflamm-ageing INFLA score lymphocyte subsets |
| title | The Phenotypic Characterization of the Oldest Italian Man from December 28, 2020, to September 23, 2021, A.T., Strengthens the Idea That the Immune System can Play a Key Role in the Attainment of Extreme Longevity |
| title_full | The Phenotypic Characterization of the Oldest Italian Man from December 28, 2020, to September 23, 2021, A.T., Strengthens the Idea That the Immune System can Play a Key Role in the Attainment of Extreme Longevity |
| title_fullStr | The Phenotypic Characterization of the Oldest Italian Man from December 28, 2020, to September 23, 2021, A.T., Strengthens the Idea That the Immune System can Play a Key Role in the Attainment of Extreme Longevity |
| title_full_unstemmed | The Phenotypic Characterization of the Oldest Italian Man from December 28, 2020, to September 23, 2021, A.T., Strengthens the Idea That the Immune System can Play a Key Role in the Attainment of Extreme Longevity |
| title_short | The Phenotypic Characterization of the Oldest Italian Man from December 28, 2020, to September 23, 2021, A.T., Strengthens the Idea That the Immune System can Play a Key Role in the Attainment of Extreme Longevity |
| title_sort | phenotypic characterization of the oldest italian man from december 28 2020 to september 23 2021 a t strengthens the idea that the immune system can play a key role in the attainment of extreme longevity |
| topic | ageing ARIP biological ageing inflamm-ageing INFLA score lymphocyte subsets |
| url | https://www.mdpi.com/2077-0383/12/24/7591 |
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