Efficacy and Safety of Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts in Improving Lipid Profile of Patients with Mild-to-Moderate Hypercholesterolemia: A Self-Control Study
The objective of the present study was to assess the lipid-lowering efficacy and safety of a novel dietary supplement containing monacolin K combined with the coenzyme Q10 and grape seed and olive tree leaf extracts (Arichol<sup>®®</sup>) on the lipid profile of adults with moderate chol...
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MDPI AG
2022-12-01
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| Series: | Nutraceuticals |
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| Online Access: | https://www.mdpi.com/1661-3821/3/1/1 |
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| author | Nicholas Angelopoulos Rodis D. Paparodis Ioannis Androulakis Anastasios Boniakos Panagiotis Anagnostis Vasilis Tsimihodimos Sarantis Livadas |
| author_facet | Nicholas Angelopoulos Rodis D. Paparodis Ioannis Androulakis Anastasios Boniakos Panagiotis Anagnostis Vasilis Tsimihodimos Sarantis Livadas |
| author_sort | Nicholas Angelopoulos |
| collection | DOAJ |
| description | The objective of the present study was to assess the lipid-lowering efficacy and safety of a novel dietary supplement containing monacolin K combined with the coenzyme Q10 and grape seed and olive tree leaf extracts (Arichol<sup>®®</sup>) on the lipid profile of adults with moderate cholesterol elevations and an absence of concomitant risk factors. We recruited patients from our Endocrinology Clinics in Greece who had low-density lipoprotein cholesterol (LDL-C) 140–180 mg/dL, were on no medications affecting serum lipid concentrations, and consented to participate in the present study. All subjects received 8-weeks supplementation with Arichol<sup>®®</sup> once daily. We measured total cholesterol (TC), high-density lipoprotein cholesterol (HDL), LDL-C, triglycerides (TG), and liver enzymes with enzymatic colorimetric assays at baseline and at the end of the study, and documented complaints potentially attributable to muscle injury. We recruited a total of 37 subjects, 33 females and 4 males (with a mean age of 55.89 ± 1.50 [mean ± standard error mean, SEM]). The treatment resulted in a statistically significant reduction in TC (from 258.9 ± 4.0 mg/dL to 212.7 ± 4.5 mg/dL, <i>p</i> < 0.001), LDL-C (from 173.8 ± 3.5 to 129.0 ± 4.5 mg/dL, <i>p</i> < 0.001), and TG (from 127.0 ± 12.2 to 117.0 ± 9.2, mg/dL, <i>p</i> = 0.012) concentrations, while HDL-C concentrations remained unchanged. There were no alterations in liver enzymes or symptoms of muscle pain in any subject. These promising results suggest that supplementation with this nutraceutical mixture favorably influences lipid concentrations during a short period of administration while exhibiting an excellent safety profile. Larger controlled studies are required to assess the potential for cardiovascular risk reduction with the above compound. |
| first_indexed | 2024-04-09T21:11:57Z |
| format | Article |
| id | doaj.art-6258446e103d4f8992c49087e7539baf |
| institution | Directory Open Access Journal |
| issn | 1661-3821 |
| language | English |
| last_indexed | 2024-04-09T21:11:57Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutraceuticals |
| spelling | doaj.art-6258446e103d4f8992c49087e7539baf2023-03-28T14:25:07ZengMDPI AGNutraceuticals1661-38212022-12-013111210.3390/nutraceuticals3010001Efficacy and Safety of Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts in Improving Lipid Profile of Patients with Mild-to-Moderate Hypercholesterolemia: A Self-Control StudyNicholas Angelopoulos0Rodis D. Paparodis1Ioannis Androulakis2Anastasios Boniakos3Panagiotis Anagnostis4Vasilis Tsimihodimos5Sarantis Livadas6Endocrine Unit, Athens Medical Centre, 65403 Athens, GreeceCenter for Diabetes and Endocrine Research, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USAEndocrine Unit, Athens Medical Centre, 65403 Athens, GreeceEndocrine Unit, Athens Medical Centre, 65403 Athens, GreeceUnit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDepartment of Internal Medicine, Medical School, University of Ioannina, 45110 Ioannina, GreeceEndocrine Unit, Athens Medical Centre, 65403 Athens, GreeceThe objective of the present study was to assess the lipid-lowering efficacy and safety of a novel dietary supplement containing monacolin K combined with the coenzyme Q10 and grape seed and olive tree leaf extracts (Arichol<sup>®®</sup>) on the lipid profile of adults with moderate cholesterol elevations and an absence of concomitant risk factors. We recruited patients from our Endocrinology Clinics in Greece who had low-density lipoprotein cholesterol (LDL-C) 140–180 mg/dL, were on no medications affecting serum lipid concentrations, and consented to participate in the present study. All subjects received 8-weeks supplementation with Arichol<sup>®®</sup> once daily. We measured total cholesterol (TC), high-density lipoprotein cholesterol (HDL), LDL-C, triglycerides (TG), and liver enzymes with enzymatic colorimetric assays at baseline and at the end of the study, and documented complaints potentially attributable to muscle injury. We recruited a total of 37 subjects, 33 females and 4 males (with a mean age of 55.89 ± 1.50 [mean ± standard error mean, SEM]). The treatment resulted in a statistically significant reduction in TC (from 258.9 ± 4.0 mg/dL to 212.7 ± 4.5 mg/dL, <i>p</i> < 0.001), LDL-C (from 173.8 ± 3.5 to 129.0 ± 4.5 mg/dL, <i>p</i> < 0.001), and TG (from 127.0 ± 12.2 to 117.0 ± 9.2, mg/dL, <i>p</i> = 0.012) concentrations, while HDL-C concentrations remained unchanged. There were no alterations in liver enzymes or symptoms of muscle pain in any subject. These promising results suggest that supplementation with this nutraceutical mixture favorably influences lipid concentrations during a short period of administration while exhibiting an excellent safety profile. Larger controlled studies are required to assess the potential for cardiovascular risk reduction with the above compound.https://www.mdpi.com/1661-3821/3/1/1monacolin Kcoenzyme Q10grape seed extractolive leaf extracthypercholesterolemia |
| spellingShingle | Nicholas Angelopoulos Rodis D. Paparodis Ioannis Androulakis Anastasios Boniakos Panagiotis Anagnostis Vasilis Tsimihodimos Sarantis Livadas Efficacy and Safety of Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts in Improving Lipid Profile of Patients with Mild-to-Moderate Hypercholesterolemia: A Self-Control Study Nutraceuticals monacolin K coenzyme Q10 grape seed extract olive leaf extract hypercholesterolemia |
| title | Efficacy and Safety of Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts in Improving Lipid Profile of Patients with Mild-to-Moderate Hypercholesterolemia: A Self-Control Study |
| title_full | Efficacy and Safety of Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts in Improving Lipid Profile of Patients with Mild-to-Moderate Hypercholesterolemia: A Self-Control Study |
| title_fullStr | Efficacy and Safety of Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts in Improving Lipid Profile of Patients with Mild-to-Moderate Hypercholesterolemia: A Self-Control Study |
| title_full_unstemmed | Efficacy and Safety of Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts in Improving Lipid Profile of Patients with Mild-to-Moderate Hypercholesterolemia: A Self-Control Study |
| title_short | Efficacy and Safety of Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts in Improving Lipid Profile of Patients with Mild-to-Moderate Hypercholesterolemia: A Self-Control Study |
| title_sort | efficacy and safety of monacolin k combined with coenzyme q10 grape seed and olive leaf extracts in improving lipid profile of patients with mild to moderate hypercholesterolemia a self control study |
| topic | monacolin K coenzyme Q10 grape seed extract olive leaf extract hypercholesterolemia |
| url | https://www.mdpi.com/1661-3821/3/1/1 |
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