Oxidative balance score inversely associated with the prevalence and incidence of metabolic syndrome: analysis of two studies of the Korean population
BackgroundPro-oxidant/antioxidant imbalances leading to chronic inflammation and insulin resistance can contribute to the development of metabolic syndrome (MetS). Oxidative Balance Score (OBS), a comprehensive measure of exposure to pro- and anti-oxidants, represents an individual’s total oxidative...
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1226107/full |
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| author | Hye-Min Park Tea-Hwa Han Yu-Jin Kwon Jun-Hyuk Lee Jun-Hyuk Lee |
| author_facet | Hye-Min Park Tea-Hwa Han Yu-Jin Kwon Jun-Hyuk Lee Jun-Hyuk Lee |
| author_sort | Hye-Min Park |
| collection | DOAJ |
| description | BackgroundPro-oxidant/antioxidant imbalances leading to chronic inflammation and insulin resistance can contribute to the development of metabolic syndrome (MetS). Oxidative Balance Score (OBS), a comprehensive measure of exposure to pro- and anti-oxidants, represents an individual’s total oxidative balance. This study aimed to evaluate the association between OBS and MetS using two large datasets.MethodsWe analyzed data from 2,735 adults older than 19 years from the 2021 Korean National Health and Nutritional Examination Survey (KNHANES) and 5,807 adults aged 40–69 years from the Korean Genome and Epidemiology Study (KoGES). In each dataset, OBS was categorized into sex-specific tertiles (T).ResultsIn KNHANES, the odds ratios and 95% confidence intervals for prevalent MetS in T3, compared to T1, were 0.44 (0.29–0.65) in men and 0.34 (0.23–0.50) in women after adjusting for confounders. In KoGES, the hazard ratios and 95% confidence intervals for incident MetS in T3, compared to T1, were 0.56 (0.48–0.65) in men and 0.63 (0.55–0.73) in women after adjusting for confounders.ConclusionOBS appears to be inversely related to MetS, which suggests that adopting lifestyle behaviors that decrease oxidative stress could be an important preventive strategy for MetS. |
| first_indexed | 2024-03-12T14:34:13Z |
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| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-12T14:34:13Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-6258c7e0bfdf4b0b801c7437ecb2940c2023-08-17T11:59:57ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-08-011010.3389/fnut.2023.12261071226107Oxidative balance score inversely associated with the prevalence and incidence of metabolic syndrome: analysis of two studies of the Korean populationHye-Min Park0Tea-Hwa Han1Yu-Jin Kwon2Jun-Hyuk Lee3Jun-Hyuk Lee4Primary Care Research Center, National Health Insurance Service Ilsan Hospital, Goyang, Republic of KoreaHealth-IT Center, Yonsei University Severance Hospital, Seoul, Republic of KoreaDepartment of Family Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Republic of KoreaDepartment of Family Medicine, Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul, Republic of KoreaDepartment of Medicine, Hanyang University School of Medicine, Seoul, Republic of KoreaBackgroundPro-oxidant/antioxidant imbalances leading to chronic inflammation and insulin resistance can contribute to the development of metabolic syndrome (MetS). Oxidative Balance Score (OBS), a comprehensive measure of exposure to pro- and anti-oxidants, represents an individual’s total oxidative balance. This study aimed to evaluate the association between OBS and MetS using two large datasets.MethodsWe analyzed data from 2,735 adults older than 19 years from the 2021 Korean National Health and Nutritional Examination Survey (KNHANES) and 5,807 adults aged 40–69 years from the Korean Genome and Epidemiology Study (KoGES). In each dataset, OBS was categorized into sex-specific tertiles (T).ResultsIn KNHANES, the odds ratios and 95% confidence intervals for prevalent MetS in T3, compared to T1, were 0.44 (0.29–0.65) in men and 0.34 (0.23–0.50) in women after adjusting for confounders. In KoGES, the hazard ratios and 95% confidence intervals for incident MetS in T3, compared to T1, were 0.56 (0.48–0.65) in men and 0.63 (0.55–0.73) in women after adjusting for confounders.ConclusionOBS appears to be inversely related to MetS, which suggests that adopting lifestyle behaviors that decrease oxidative stress could be an important preventive strategy for MetS.https://www.frontiersin.org/articles/10.3389/fnut.2023.1226107/fulloxidative balance scorepro-oxidantantioxidantmetabolic syndromeKorean Genome and Epidemiology Study |
| spellingShingle | Hye-Min Park Tea-Hwa Han Yu-Jin Kwon Jun-Hyuk Lee Jun-Hyuk Lee Oxidative balance score inversely associated with the prevalence and incidence of metabolic syndrome: analysis of two studies of the Korean population Frontiers in Nutrition oxidative balance score pro-oxidant antioxidant metabolic syndrome Korean Genome and Epidemiology Study |
| title | Oxidative balance score inversely associated with the prevalence and incidence of metabolic syndrome: analysis of two studies of the Korean population |
| title_full | Oxidative balance score inversely associated with the prevalence and incidence of metabolic syndrome: analysis of two studies of the Korean population |
| title_fullStr | Oxidative balance score inversely associated with the prevalence and incidence of metabolic syndrome: analysis of two studies of the Korean population |
| title_full_unstemmed | Oxidative balance score inversely associated with the prevalence and incidence of metabolic syndrome: analysis of two studies of the Korean population |
| title_short | Oxidative balance score inversely associated with the prevalence and incidence of metabolic syndrome: analysis of two studies of the Korean population |
| title_sort | oxidative balance score inversely associated with the prevalence and incidence of metabolic syndrome analysis of two studies of the korean population |
| topic | oxidative balance score pro-oxidant antioxidant metabolic syndrome Korean Genome and Epidemiology Study |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1226107/full |
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