An Orthotopic Patient-Derived Xenograft (PDX) Model Allows the Analysis of Metastasis-Associated Features in Colorectal Cancer

An Orthotopic Patient-Derived Xenograft (PDX) Model Allows the Analysis of Metastasis-Associated Features in Colorectal Cancer

Metastasis is the primary cause of death in patients with colorectal cancer (CRC), urging the need for preclinical models that recapitulate the metastatic process at the individual patient level. We used an orthotopic patient-derived xenograft (PDX) obtained through the direct implantation of freshl...

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Bibliographic Details
Main Authors: Maria Laura De Angelis, Federica Francescangeli, Chiara Nicolazzo, Eljona Xhelili, Filippo La Torre, Lidia Colace, Alessandro Bruselles, Daniele Macchia, Sara Vitale, Paola Gazzaniga, Marta Baiocchi, Ann Zeuner
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Oncology
Subjects:
patient-derived xenograft (PDX)
colorectal cancer (CRC)
metastasis
epithelial-to-mesenchymal transition (EMT)
organoids
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.869485/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.869485/full

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