Characterization, management, and risk factors of hyperglycemia during PI3K or AKT inhibitor treatment

Characterization, management, and risk factors of hyperglycemia during PI3K or AKT inhibitor treatment

Abstract Purpose The phosphoinositide 3‐kinase (PI3K)/protein kinase B (AKT) pathway controls insulin sensitivity and glucose metabolism. Hyperglycemia is one of the most common on‐target adverse effects (AEs) of PI3K/AKT inhibitors. As several PI3K and AKT inhibitors are approved by the United Stat...

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Bibliographic Details
Main Authors: Dazhi Liu, Michael A. Weintraub, Christine Garcia, Marcus D. Goncalves, Ann Elizabeth Sisk, Alissa Casas, James J. Harding, Stephen Harnicar, Alexander Drilon, Komal Jhaveri, James H. Flory
Format: Article
Language:English
Published: Wiley 2022-04-01
Series:Cancer Medicine
Subjects:
hyperglycemia
PI3K/AKT inhibitors
risk factors
SGLT2 inhibitors
toxicity management
Online Access:https://doi.org/10.1002/cam4.4579

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