In Vitro and In Vivo Characterisation of a Mucoadhesive Buccal Film Loaded with Doxycycline Hyclate for Topical Application in Periodontitis

In Vitro and In Vivo Characterisation of a Mucoadhesive Buccal Film Loaded with Doxycycline Hyclate for Topical Application in Periodontitis

Mucoadhesive films loaded with doxycycline hyclate (Doxy Hyc), consisting of mixtures of hydroxypropylmethyl cellulose (HPMC) E3, K4 and polyacrylic acid (Carbopol 940), were prepared by casting method, aiming to design a formulation intended for application in the oral cavity. The obtained film for...

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Bibliographic Details
Main Authors: Elena Dinte, Dana Maria Muntean, Vlad Andrei, Bianca Adina Boșca, Cristian Mircea Dudescu, Lucian Barbu-Tudoran, Gheorghe Borodi, Sanda Andrei, Adrian Florin Gal, Vasile Rus, Luciana-Mădălina Gherman, Oana Cadar, Reka Barabas, Mihaela Niculae, Aranka Ilea
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceutics
Subjects:
antibiotic
bioadhesive film
drug delivery
MMP
oral cavity
Online Access:https://www.mdpi.com/1999-4923/15/2/580

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