Early mortality risk factors at the beginning of continuous renal replacement therapy for acute kidney injury
Introduction: Acute kidney injury (AKI) occurs in more than 50% of critically ill patients, 23% need renal replacement therapy. The aim of our study is to identify early mortality risk factors at the beginning of continuous renal replacement therapy (CRRT) for AKI. Methods: A cohort study was perfor...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-01-01
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| Series: | Cogent Medicine |
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| Online Access: | http://dx.doi.org/10.1080/2331205X.2017.1407485 |
| _version_ | 1811201475781591040 |
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| author | Camilo Alberto Gonzalez Jessica Liliana Pinto Viviana Orozco Kateir Contreras Paola Garcia Patricia Rodriguez Juan Patiño Jorge Echeverri |
| author_facet | Camilo Alberto Gonzalez Jessica Liliana Pinto Viviana Orozco Kateir Contreras Paola Garcia Patricia Rodriguez Juan Patiño Jorge Echeverri |
| author_sort | Camilo Alberto Gonzalez |
| collection | DOAJ |
| description | Introduction: Acute kidney injury (AKI) occurs in more than 50% of critically ill patients, 23% need renal replacement therapy. The aim of our study is to identify early mortality risk factors at the beginning of continuous renal replacement therapy (CRRT) for AKI. Methods: A cohort study was performed in adult patients with AKI who required CRRT in the intensive care unit of a university hospital. We did a bivariate and multivariate analysis for early death, defined as death within 24 h of onset of CRRT. Results: 214 AKI patient required CRRT, The mean age was 61.5 years (± 15.47), 57.73% men. The most frequent cause of AKI was sepsis in 30.9% of cases. A total of 774 CRRT days were conducted with a median of 3 days per patient (1–19). Mean Charlson comorbidity index was 5.22 (± 2.85), APACHE II score 29.65 (± 6.66), total non-renal SOFA had a median of 11 (range 6–18) at the time of starting therapy. The hospital mortality was 68.4% and early mortality was 19.07%. In multivariate analysis for early death: lactate levels (p = 0.007), glucose (p = 0.01) and age (p = 0.02) were independent risk factors with AUC of 0.73. Conclusions: Patients with AKI on CRRT have high mortality. Age, Low glucose and high lactate at onset of CRRT are independent risk factors of early death. We need an external validation. |
| first_indexed | 2024-04-12T02:22:16Z |
| format | Article |
| id | doaj.art-626387a4dde249d3b9874d4601728830 |
| institution | Directory Open Access Journal |
| issn | 2331-205X |
| language | English |
| last_indexed | 2024-04-12T02:22:16Z |
| publishDate | 2018-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cogent Medicine |
| spelling | doaj.art-626387a4dde249d3b9874d46017288302022-12-22T03:52:06ZengTaylor & Francis GroupCogent Medicine2331-205X2018-01-015110.1080/2331205X.2017.14074851407485Early mortality risk factors at the beginning of continuous renal replacement therapy for acute kidney injuryCamilo Alberto Gonzalez0Jessica Liliana Pinto1Viviana Orozco2Kateir Contreras3Paola Garcia4Patricia Rodriguez5Juan Patiño6Jorge Echeverri7Hospital Universitario San Ignacio, Pontificia Universidad JaverianaHospital Universitario San Ignacio, Pontificia Universidad JaverianaHospital Universitario San Ignacio, Pontificia Universidad JaverianaHospital Universitario San Ignacio, Pontificia Universidad JaverianaHospital Universitario San Ignacio, Pontificia Universidad JaverianaHospital Universitario San Ignacio, Pontificia Universidad JaverianaHospital Universitario San Ignacio, Pontificia Universidad JaverianaHospital Militar Central, Universidad NuevaIntroduction: Acute kidney injury (AKI) occurs in more than 50% of critically ill patients, 23% need renal replacement therapy. The aim of our study is to identify early mortality risk factors at the beginning of continuous renal replacement therapy (CRRT) for AKI. Methods: A cohort study was performed in adult patients with AKI who required CRRT in the intensive care unit of a university hospital. We did a bivariate and multivariate analysis for early death, defined as death within 24 h of onset of CRRT. Results: 214 AKI patient required CRRT, The mean age was 61.5 years (± 15.47), 57.73% men. The most frequent cause of AKI was sepsis in 30.9% of cases. A total of 774 CRRT days were conducted with a median of 3 days per patient (1–19). Mean Charlson comorbidity index was 5.22 (± 2.85), APACHE II score 29.65 (± 6.66), total non-renal SOFA had a median of 11 (range 6–18) at the time of starting therapy. The hospital mortality was 68.4% and early mortality was 19.07%. In multivariate analysis for early death: lactate levels (p = 0.007), glucose (p = 0.01) and age (p = 0.02) were independent risk factors with AUC of 0.73. Conclusions: Patients with AKI on CRRT have high mortality. Age, Low glucose and high lactate at onset of CRRT are independent risk factors of early death. We need an external validation.http://dx.doi.org/10.1080/2331205X.2017.1407485acute kidney injuryrenal replacement therapymortalitycritical illnessrenal insufficiency |
| spellingShingle | Camilo Alberto Gonzalez Jessica Liliana Pinto Viviana Orozco Kateir Contreras Paola Garcia Patricia Rodriguez Juan Patiño Jorge Echeverri Early mortality risk factors at the beginning of continuous renal replacement therapy for acute kidney injury Cogent Medicine acute kidney injury renal replacement therapy mortality critical illness renal insufficiency |
| title | Early mortality risk factors at the beginning of continuous renal replacement therapy for acute kidney injury |
| title_full | Early mortality risk factors at the beginning of continuous renal replacement therapy for acute kidney injury |
| title_fullStr | Early mortality risk factors at the beginning of continuous renal replacement therapy for acute kidney injury |
| title_full_unstemmed | Early mortality risk factors at the beginning of continuous renal replacement therapy for acute kidney injury |
| title_short | Early mortality risk factors at the beginning of continuous renal replacement therapy for acute kidney injury |
| title_sort | early mortality risk factors at the beginning of continuous renal replacement therapy for acute kidney injury |
| topic | acute kidney injury renal replacement therapy mortality critical illness renal insufficiency |
| url | http://dx.doi.org/10.1080/2331205X.2017.1407485 |
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