Global burden of esophageal cancer attributable to high BMI in 204 countries and territories: 1990–2019
Abstract Background Esophageal cancer (EC), a common and fatal disease, includes two histological subtypes; esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (ECA). To aid policymakers in the allocation of resources for the prevention and treatment of EC, updated data on EC dea...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-03-01
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| Series: | Thoracic Cancer |
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| Online Access: | https://doi.org/10.1111/1759-7714.15239 |
| _version_ | 1797246858278469632 |
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| author | Zhiming Chen Xingxing Zhang Jianxue Zhai Jiayang Fan Yikuan Cai Tianlan Ye Zhizhi Wang Kaican Cai |
| author_facet | Zhiming Chen Xingxing Zhang Jianxue Zhai Jiayang Fan Yikuan Cai Tianlan Ye Zhizhi Wang Kaican Cai |
| author_sort | Zhiming Chen |
| collection | DOAJ |
| description | Abstract Background Esophageal cancer (EC), a common and fatal disease, includes two histological subtypes; esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (ECA). To aid policymakers in the allocation of resources for the prevention and treatment of EC, updated data on EC deaths and disability‐adjusted life years (DALYs) attributable to high body mass index (BMI) are necessary. The objective of this study was to identify trends in EC associated with high BMI between 1990 and 2019 using 2019 Global Burden of Disease data. Methods In this observational population‐based study, epidemiological data on the association between high BMI and EC were obtained from GBD 2019. The age‐standardized mortality rate (ASMRs) and disability‐adjusted life year rate (ASDRs) attributable to high BMI‐related EC were stratified by year, age, country, and sociodemographic index (SDI). The estimated annual percentage change (EAPC) was calculated to evaluate the temporal trends of the ASMRs and ASDRs between 1990 and 2019. Results In 2019, the proportion of EC deaths and DALYs attributed to high BMI was 18.1% and 18.9%, respectively, resulting in 89 904 (95% confidence interval [CI]: 27 879–171 255) deaths and 2 202 314 (95% CI: 681 901–4 173 080) DALYs. High BMI‐related deaths and DALYs showed a strong upward trend, increasing by more than two‐fold since 1990. East Asia and Western Europe showed the highest risk of EC mortality and DALYs attributable to high BMI; China and the USA bear the greatest burden. The ASMR and ASDR increased in five SDI regions. Conclusions The incidence of EC is increasing, particularly in developing nations, which may be attributed to the prevalence of high BMI. To mitigate the impact of high BMI on the incidence of EC, it is important to increase awareness of its deleterious effects, which may alleviate the burden of this disease. |
| first_indexed | 2024-04-24T19:49:28Z |
| format | Article |
| id | doaj.art-6266bf99a04147a6863852ce2b7ece02 |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-04-24T19:49:28Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-6266bf99a04147a6863852ce2b7ece022024-03-25T01:41:28ZengWileyThoracic Cancer1759-77061759-77142024-03-0115968169210.1111/1759-7714.15239Global burden of esophageal cancer attributable to high BMI in 204 countries and territories: 1990–2019Zhiming Chen0Xingxing Zhang1Jianxue Zhai2Jiayang Fan3Yikuan Cai4Tianlan Ye5Zhizhi Wang6Kaican Cai7Department of Thoracic Surgery, Nanfang Hospital Southern Medical University Guangzhou ChinaDepartment of General Surgery, Nanfang Hospital Southern Medical University Guangzhou ChinaDepartment of Thoracic Surgery, Nanfang Hospital Southern Medical University Guangzhou ChinaDepartment of Thoracic Surgery, Nanfang Hospital Southern Medical University Guangzhou ChinaDepartment of Thoracic Surgery, Nanfang Hospital Southern Medical University Guangzhou ChinaDepartment of Thoracic Surgery, Nanfang Hospital Southern Medical University Guangzhou ChinaDepartment of Thoracic Surgery, Nanfang Hospital Southern Medical University Guangzhou ChinaDepartment of Thoracic Surgery, Nanfang Hospital Southern Medical University Guangzhou ChinaAbstract Background Esophageal cancer (EC), a common and fatal disease, includes two histological subtypes; esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (ECA). To aid policymakers in the allocation of resources for the prevention and treatment of EC, updated data on EC deaths and disability‐adjusted life years (DALYs) attributable to high body mass index (BMI) are necessary. The objective of this study was to identify trends in EC associated with high BMI between 1990 and 2019 using 2019 Global Burden of Disease data. Methods In this observational population‐based study, epidemiological data on the association between high BMI and EC were obtained from GBD 2019. The age‐standardized mortality rate (ASMRs) and disability‐adjusted life year rate (ASDRs) attributable to high BMI‐related EC were stratified by year, age, country, and sociodemographic index (SDI). The estimated annual percentage change (EAPC) was calculated to evaluate the temporal trends of the ASMRs and ASDRs between 1990 and 2019. Results In 2019, the proportion of EC deaths and DALYs attributed to high BMI was 18.1% and 18.9%, respectively, resulting in 89 904 (95% confidence interval [CI]: 27 879–171 255) deaths and 2 202 314 (95% CI: 681 901–4 173 080) DALYs. High BMI‐related deaths and DALYs showed a strong upward trend, increasing by more than two‐fold since 1990. East Asia and Western Europe showed the highest risk of EC mortality and DALYs attributable to high BMI; China and the USA bear the greatest burden. The ASMR and ASDR increased in five SDI regions. Conclusions The incidence of EC is increasing, particularly in developing nations, which may be attributed to the prevalence of high BMI. To mitigate the impact of high BMI on the incidence of EC, it is important to increase awareness of its deleterious effects, which may alleviate the burden of this disease.https://doi.org/10.1111/1759-7714.15239esophageal cancerglobal burden of disease (GBD)high body mass index (BMI) |
| spellingShingle | Zhiming Chen Xingxing Zhang Jianxue Zhai Jiayang Fan Yikuan Cai Tianlan Ye Zhizhi Wang Kaican Cai Global burden of esophageal cancer attributable to high BMI in 204 countries and territories: 1990–2019 Thoracic Cancer esophageal cancer global burden of disease (GBD) high body mass index (BMI) |
| title | Global burden of esophageal cancer attributable to high BMI in 204 countries and territories: 1990–2019 |
| title_full | Global burden of esophageal cancer attributable to high BMI in 204 countries and territories: 1990–2019 |
| title_fullStr | Global burden of esophageal cancer attributable to high BMI in 204 countries and territories: 1990–2019 |
| title_full_unstemmed | Global burden of esophageal cancer attributable to high BMI in 204 countries and territories: 1990–2019 |
| title_short | Global burden of esophageal cancer attributable to high BMI in 204 countries and territories: 1990–2019 |
| title_sort | global burden of esophageal cancer attributable to high bmi in 204 countries and territories 1990 2019 |
| topic | esophageal cancer global burden of disease (GBD) high body mass index (BMI) |
| url | https://doi.org/10.1111/1759-7714.15239 |
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