176 COVID-19 infection risk in patients with non-syndromic orofacial clefts during pandemic in Puerto Rico
OBJECTIVES/GOALS: Patients with nsCL/P are prone to infections due to their open like wound cleft and immune system susceptibility. COVID-19 affected nsCL/P patients access to care and treatment delays. This study will determine COVID-19 infection risk between children with nsCL/P compared to those...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-04-01
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| Series: | Journal of Clinical and Translational Science |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2059866122000826/type/journal_article |
| _version_ | 1827993740955877376 |
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| author | Yinayra Victoria Natalio Debs Augusto Elias Carmen J Buxo |
| author_facet | Yinayra Victoria Natalio Debs Augusto Elias Carmen J Buxo |
| author_sort | Yinayra Victoria |
| collection | DOAJ |
| description | OBJECTIVES/GOALS: Patients with nsCL/P are prone to infections due to their open like wound cleft and immune system susceptibility. COVID-19 affected nsCL/P patients access to care and treatment delays. This study will determine COVID-19 infection risk between children with nsCL/P compared to those unaffected. METHODS/STUDY POPULATION: Retrospective cohort of children 5 years old and under with nsCL/P (exposed group) and children without nsCL/P (unaffected group); matched by age and gender. Participants will be selected from ongoing case-control study (n=500), School of Dental Medicine, and Pediatric University Hospital. Power analysis will calculate minimum sample size (power=0.80 alpha=0.05). Exclusion criteria: syndromic clefts, patients without diagnosis information and with history of co-morbidity. Other bacterial and viral infections present at the time of COVID-19 diagnosis, sex, age, geographic location, COVID-19 vaccination status and others will be considered as possible cofounders. Descriptive statistics, Chi-square, Odds Ratios at 95% confidence intervals and multiple logistic regression will be estimated. RESULTS/ANTICIPATED RESULTS: We hypothesize that we will identify an increased risk of COVID-19 infection in children with nsCL/P than in those unaffected or children without nsCL/P. Children with nsCL/P will also have an increased risk of symptoms and complications of COVID-19 infection than those unaffected. DISCUSSION/SIGNIFICANCE: Knowing the increased risk of COVID-19 infection in children with nsCL/P will aid to prioritize treatment. If a higher risk of COVID-19 infection is found, it will generate a need to modify elective surgery status to semi-elective; minimizing delayed treatments, unnecessary hospitalizations, complications and increased cost of treatment. |
| first_indexed | 2024-04-10T04:30:30Z |
| format | Article |
| id | doaj.art-626759fdfcf24fc4a473ec31e87f0694 |
| institution | Directory Open Access Journal |
| issn | 2059-8661 |
| language | English |
| last_indexed | 2024-04-10T04:30:30Z |
| publishDate | 2022-04-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Clinical and Translational Science |
| spelling | doaj.art-626759fdfcf24fc4a473ec31e87f06942023-03-10T07:53:49ZengCambridge University PressJournal of Clinical and Translational Science2059-86612022-04-016222210.1017/cts.2022.82176 COVID-19 infection risk in patients with non-syndromic orofacial clefts during pandemic in Puerto RicoYinayra Victoria0Natalio Debs1Augusto Elias2Carmen J Buxo3University of Puerto Rico-Medical Science Campus-University of Puerto Rico School of Dental Medicine (UPR SDM)Professor and Assistant Dean of Research (UPR SDM)Associate professor & Director of the Dental Genomic and Craniofacial Core (UPR SDM)OBJECTIVES/GOALS: Patients with nsCL/P are prone to infections due to their open like wound cleft and immune system susceptibility. COVID-19 affected nsCL/P patients access to care and treatment delays. This study will determine COVID-19 infection risk between children with nsCL/P compared to those unaffected. METHODS/STUDY POPULATION: Retrospective cohort of children 5 years old and under with nsCL/P (exposed group) and children without nsCL/P (unaffected group); matched by age and gender. Participants will be selected from ongoing case-control study (n=500), School of Dental Medicine, and Pediatric University Hospital. Power analysis will calculate minimum sample size (power=0.80 alpha=0.05). Exclusion criteria: syndromic clefts, patients without diagnosis information and with history of co-morbidity. Other bacterial and viral infections present at the time of COVID-19 diagnosis, sex, age, geographic location, COVID-19 vaccination status and others will be considered as possible cofounders. Descriptive statistics, Chi-square, Odds Ratios at 95% confidence intervals and multiple logistic regression will be estimated. RESULTS/ANTICIPATED RESULTS: We hypothesize that we will identify an increased risk of COVID-19 infection in children with nsCL/P than in those unaffected or children without nsCL/P. Children with nsCL/P will also have an increased risk of symptoms and complications of COVID-19 infection than those unaffected. DISCUSSION/SIGNIFICANCE: Knowing the increased risk of COVID-19 infection in children with nsCL/P will aid to prioritize treatment. If a higher risk of COVID-19 infection is found, it will generate a need to modify elective surgery status to semi-elective; minimizing delayed treatments, unnecessary hospitalizations, complications and increased cost of treatment.https://www.cambridge.org/core/product/identifier/S2059866122000826/type/journal_article |
| spellingShingle | Yinayra Victoria Natalio Debs Augusto Elias Carmen J Buxo 176 COVID-19 infection risk in patients with non-syndromic orofacial clefts during pandemic in Puerto Rico Journal of Clinical and Translational Science |
| title | 176 COVID-19 infection risk in patients with non-syndromic orofacial clefts during pandemic in Puerto Rico |
| title_full | 176 COVID-19 infection risk in patients with non-syndromic orofacial clefts during pandemic in Puerto Rico |
| title_fullStr | 176 COVID-19 infection risk in patients with non-syndromic orofacial clefts during pandemic in Puerto Rico |
| title_full_unstemmed | 176 COVID-19 infection risk in patients with non-syndromic orofacial clefts during pandemic in Puerto Rico |
| title_short | 176 COVID-19 infection risk in patients with non-syndromic orofacial clefts during pandemic in Puerto Rico |
| title_sort | 176 covid 19 infection risk in patients with non syndromic orofacial clefts during pandemic in puerto rico |
| url | https://www.cambridge.org/core/product/identifier/S2059866122000826/type/journal_article |
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