Roles and regulation of Aquaporin-3 in maintaining the gut health: an updated review
Aquaporin-3 (AQP3) is a predominant water channel protein expressed in the intestine, and plays important roles in the gut physiology and pathophysiology due to its permeability to water, glycerol and hydrogen peroxide. In this review, we systematically summarized the current understanding of the ex...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1264570/full |
| _version_ | 1797449284848713728 |
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| author | Cui Zhu Xiaoyan Nie Qi Lu Yinshan Bai Zongyong Jiang |
| author_facet | Cui Zhu Xiaoyan Nie Qi Lu Yinshan Bai Zongyong Jiang |
| author_sort | Cui Zhu |
| collection | DOAJ |
| description | Aquaporin-3 (AQP3) is a predominant water channel protein expressed in the intestine, and plays important roles in the gut physiology and pathophysiology due to its permeability to water, glycerol and hydrogen peroxide. In this review, we systematically summarized the current understanding of the expression of AQP3 in the intestine of different species, and focused on the potential roles of AQP3 in water transport, different types of diarrhea and constipation, intestinal inflammation, intestinal barrier function, oxidative stress, and autophagy. These updated findings have supported that AQP3 may function as an important target in maintaining gut health of human and animals. |
| first_indexed | 2024-03-09T14:22:43Z |
| format | Article |
| id | doaj.art-62676a8c7e30429dad180e26b24bd6c1 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-03-09T14:22:43Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-62676a8c7e30429dad180e26b24bd6c12023-11-28T09:24:14ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-11-011410.3389/fphys.2023.12645701264570Roles and regulation of Aquaporin-3 in maintaining the gut health: an updated reviewCui Zhu0Xiaoyan Nie1Qi Lu2Yinshan Bai3Zongyong Jiang4School of Life Science and Engineering, Foshan University, Foshan, ChinaSchool of Life Science and Engineering, Foshan University, Foshan, ChinaSchool of Life Science and Engineering, Foshan University, Foshan, ChinaSchool of Life Science and Engineering, Foshan University, Foshan, ChinaInstitute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, ChinaAquaporin-3 (AQP3) is a predominant water channel protein expressed in the intestine, and plays important roles in the gut physiology and pathophysiology due to its permeability to water, glycerol and hydrogen peroxide. In this review, we systematically summarized the current understanding of the expression of AQP3 in the intestine of different species, and focused on the potential roles of AQP3 in water transport, different types of diarrhea and constipation, intestinal inflammation, intestinal barrier function, oxidative stress, and autophagy. These updated findings have supported that AQP3 may function as an important target in maintaining gut health of human and animals.https://www.frontiersin.org/articles/10.3389/fphys.2023.1264570/fullAquaporin 3gut healthbarrier functioninflammationoxidative stressautophagy |
| spellingShingle | Cui Zhu Xiaoyan Nie Qi Lu Yinshan Bai Zongyong Jiang Roles and regulation of Aquaporin-3 in maintaining the gut health: an updated review Frontiers in Physiology Aquaporin 3 gut health barrier function inflammation oxidative stress autophagy |
| title | Roles and regulation of Aquaporin-3 in maintaining the gut health: an updated review |
| title_full | Roles and regulation of Aquaporin-3 in maintaining the gut health: an updated review |
| title_fullStr | Roles and regulation of Aquaporin-3 in maintaining the gut health: an updated review |
| title_full_unstemmed | Roles and regulation of Aquaporin-3 in maintaining the gut health: an updated review |
| title_short | Roles and regulation of Aquaporin-3 in maintaining the gut health: an updated review |
| title_sort | roles and regulation of aquaporin 3 in maintaining the gut health an updated review |
| topic | Aquaporin 3 gut health barrier function inflammation oxidative stress autophagy |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1264570/full |
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