HSA—Coated Magnetic Nanoparticles for MRI-Guided Photodynamic Cancer Therapy
Background: Photodynamic therapy (PDT) is a promising technique for cancer treatment; however, low tissue permeability for irradiating light and insufficient photosensitizer (PS) accumulation in tumors limit its clinical potential. Nanoparticles are engineered to improve selective drug delivery to t...
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| Format: | Article |
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MDPI AG
2018-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/10/4/284 |
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| author | Petr Ostroverkhov Alevtina Semkina Victor Naumenko Ekaterina Plotnikova Raisa Yakubovskaya Stepan Vodopyanov Artem Abakumov Alexander Majouga Michael Grin Vladimir Chekhonin Maxim Abakumov |
| author_facet | Petr Ostroverkhov Alevtina Semkina Victor Naumenko Ekaterina Plotnikova Raisa Yakubovskaya Stepan Vodopyanov Artem Abakumov Alexander Majouga Michael Grin Vladimir Chekhonin Maxim Abakumov |
| author_sort | Petr Ostroverkhov |
| collection | DOAJ |
| description | Background: Photodynamic therapy (PDT) is a promising technique for cancer treatment; however, low tissue permeability for irradiating light and insufficient photosensitizer (PS) accumulation in tumors limit its clinical potential. Nanoparticles are engineered to improve selective drug delivery to tumor sites, but its accumulation is highly variable between tumors and patients. Identifying PS accumulation peak in a personalized manner is crucial for therapeutic outcome. Magnetic nanoparticles (MNPs) provide opportunity for tracking drug accumulation in dynamics using non-invasive magnetic resonance imaging (MRI). The purpose of the study was to evaluate MNP loaded with PS as a theranostic tool for treating cancer in mice xenograft colon cancer models. Methods: MNPs coated with human serum albumin (HSA) were loaded with bacteriochlorine <i>a</i>. MRI, atomic emission spectroscopy (AES) and fluorescent imaging were used to study MNP and drug accumulation rates and dynamics in CT26 tumors. Tumor growth curves were evaluated in animals that received PDT at different time points upon MNP systemic injection. Results: Peak MNP accumulation in tumors was detected by MRI 60 min post injection (pi) and the data were verified by AES and fluorescent imaging. Up to 17% of injected dose/g of tissue was delivered to malignant tissues 24 h after injection. Consistent with MRI predicted drug accumulation peak PDT performed 60 min after intravenous injection was more efficient in inhibiting tumor growth than treatment scheduled 30 min and 240 min pi. Conclusions: PS loading on HAS-coated MNPs is a perspective approach to increase drug delivery to tumor site. Tracking for MNP accumulation by MRI can be used to predict drug concentration peak in tumors and to adjust PDT time scheduling for improved antitumor response. |
| first_indexed | 2024-04-11T21:43:54Z |
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| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T21:43:54Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-626a649d8c0248d39709f690564363732022-12-22T04:01:28ZengMDPI AGPharmaceutics1999-49232018-12-0110428410.3390/pharmaceutics10040284pharmaceutics10040284HSA—Coated Magnetic Nanoparticles for MRI-Guided Photodynamic Cancer TherapyPetr Ostroverkhov0Alevtina Semkina1Victor Naumenko2Ekaterina Plotnikova3Raisa Yakubovskaya4Stepan Vodopyanov5Artem Abakumov6Alexander Majouga7Michael Grin8Vladimir Chekhonin9Maxim Abakumov10Institute of Fine Chemical Technology, Moscow Technological University (MIREA), 86 Vernadsky Avenue, Moscow 119571, RussiaDepartment of Medical Nanobiotechnology, Pirogov Russian National Research Medical University, Ostrovitianov str. 1, Moscow 117997, RussiaLaboratory of Biomedical Nanomaterials, National Research Technological University “MISiS”, Leninskiy Prospekt 4, Moscow 119049, RussiaFSBI NMRRC of the Ministry of Health of the Russian Federation, 2-Y Botkinskiy Proyezd 3, Moscow 125284, RussiaFSBI NMRRC of the Ministry of Health of the Russian Federation, 2-Y Botkinskiy Proyezd 3, Moscow 125284, RussiaLaboratory of Biomedical Nanomaterials, National Research Technological University “MISiS”, Leninskiy Prospekt 4, Moscow 119049, RussiaSkolkovo Institute of Science and Technology, Nobelya Ulitsa 3, Moscow 121205, RussiaLaboratory of Biomedical Nanomaterials, National Research Technological University “MISiS”, Leninskiy Prospekt 4, Moscow 119049, RussiaSkolkovo Institute of Science and Technology, Nobelya Ulitsa 3, Moscow 121205, RussiaDepartment of Medical Nanobiotechnology, Pirogov Russian National Research Medical University, Ostrovitianov str. 1, Moscow 117997, RussiaDepartment of Medical Nanobiotechnology, Pirogov Russian National Research Medical University, Ostrovitianov str. 1, Moscow 117997, RussiaBackground: Photodynamic therapy (PDT) is a promising technique for cancer treatment; however, low tissue permeability for irradiating light and insufficient photosensitizer (PS) accumulation in tumors limit its clinical potential. Nanoparticles are engineered to improve selective drug delivery to tumor sites, but its accumulation is highly variable between tumors and patients. Identifying PS accumulation peak in a personalized manner is crucial for therapeutic outcome. Magnetic nanoparticles (MNPs) provide opportunity for tracking drug accumulation in dynamics using non-invasive magnetic resonance imaging (MRI). The purpose of the study was to evaluate MNP loaded with PS as a theranostic tool for treating cancer in mice xenograft colon cancer models. Methods: MNPs coated with human serum albumin (HSA) were loaded with bacteriochlorine <i>a</i>. MRI, atomic emission spectroscopy (AES) and fluorescent imaging were used to study MNP and drug accumulation rates and dynamics in CT26 tumors. Tumor growth curves were evaluated in animals that received PDT at different time points upon MNP systemic injection. Results: Peak MNP accumulation in tumors was detected by MRI 60 min post injection (pi) and the data were verified by AES and fluorescent imaging. Up to 17% of injected dose/g of tissue was delivered to malignant tissues 24 h after injection. Consistent with MRI predicted drug accumulation peak PDT performed 60 min after intravenous injection was more efficient in inhibiting tumor growth than treatment scheduled 30 min and 240 min pi. Conclusions: PS loading on HAS-coated MNPs is a perspective approach to increase drug delivery to tumor site. Tracking for MNP accumulation by MRI can be used to predict drug concentration peak in tumors and to adjust PDT time scheduling for improved antitumor response.https://www.mdpi.com/1999-4923/10/4/284Photodynamic therapyiron oxide nanoparticleshuman serum albuminMRI |
| spellingShingle | Petr Ostroverkhov Alevtina Semkina Victor Naumenko Ekaterina Plotnikova Raisa Yakubovskaya Stepan Vodopyanov Artem Abakumov Alexander Majouga Michael Grin Vladimir Chekhonin Maxim Abakumov HSA—Coated Magnetic Nanoparticles for MRI-Guided Photodynamic Cancer Therapy Pharmaceutics Photodynamic therapy iron oxide nanoparticles human serum albumin MRI |
| title | HSA—Coated Magnetic Nanoparticles for MRI-Guided Photodynamic Cancer Therapy |
| title_full | HSA—Coated Magnetic Nanoparticles for MRI-Guided Photodynamic Cancer Therapy |
| title_fullStr | HSA—Coated Magnetic Nanoparticles for MRI-Guided Photodynamic Cancer Therapy |
| title_full_unstemmed | HSA—Coated Magnetic Nanoparticles for MRI-Guided Photodynamic Cancer Therapy |
| title_short | HSA—Coated Magnetic Nanoparticles for MRI-Guided Photodynamic Cancer Therapy |
| title_sort | hsa coated magnetic nanoparticles for mri guided photodynamic cancer therapy |
| topic | Photodynamic therapy iron oxide nanoparticles human serum albumin MRI |
| url | https://www.mdpi.com/1999-4923/10/4/284 |
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