DNA methylation of alternative promoters directs tissue specific expression of Epac2 isoforms.

DNA methylation of alternative promoters directs tissue specific expression of Epac2 isoforms.

Epac 1 and Epac 2 (Epac1/2; exchange factors directly activated by cAMP) are multidomain proteins that mediate cellular responses upon activation by the signaling molecule cAMP. Epac1 is ubiquitously expressed, whereas Epac2 exhibits a restricted expression pattern. The gene encoding Epac2 gives ris...

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Bibliographic Details
Main Authors: Erling A Hoivik, Solveig L Witsoe, Inger R Bergheim, Yunjian Xu, Ida Jakobsson, Anders Tengholm, Stein Ove Doskeland, Marit Bakke
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3701594?pdf=render

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http://europepmc.org/articles/PMC3701594?pdf=render

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