Diagnostic value of neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for detection of renal failure in hypertensives: a case–control study in a regional hospital in Ghana
Abstract Background Renal failure is one of the most serious vascular effects of hypertension. For better therapy and prevention of complications, early kidney disease identification in these patients is absolutely essential. However, current studies have proposed plasma Neutrophil Gelatinase Associ...
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | BMC Nephrology |
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| Online Access: | https://doi.org/10.1186/s12882-023-03120-6 |
| _version_ | 1797836546967076864 |
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| author | Mark Danquah William K. B. A. Owiredu B. A. Eghan Jnr Dorcas Serwaa Enoch Odame Anto Maxwell Owusu Peprah Christian Obirikorang Linda A. Fondjo |
| author_facet | Mark Danquah William K. B. A. Owiredu B. A. Eghan Jnr Dorcas Serwaa Enoch Odame Anto Maxwell Owusu Peprah Christian Obirikorang Linda A. Fondjo |
| author_sort | Mark Danquah |
| collection | DOAJ |
| description | Abstract Background Renal failure is one of the most serious vascular effects of hypertension. For better therapy and prevention of complications, early kidney disease identification in these patients is absolutely essential. However, current studies have proposed plasma Neutrophil Gelatinase Associated Lipocalin (pNGAL) to be a better biomarker comparative to serum creatinine (SCr). This study assessed the diagnostic utility of plasma neutrophil gelatinase-associated lipocalin (pNGAL) as a biomarker for early nephropathy diagnosis in hypertensive individuals. Methods This hospital-based case–control study comprised 140 hypertensives and 70 healthy participants. A well-structured questionnaire and patient case notes were used to document relevant demographic and clinical information. 5 ml of venous blood sample was taken to measure fasting blood sugar levels, creatinine, and plasma NGAL levels. All data were analyzed using the Statistical Package for Social Sciences (SPSS release 20.0, copyrite©SPSS Inc.) and a p-value < 0.05 was considered statistically significant. Results In this study the plasma neutrophil gelatinase-associated lipocalin (NGAL) levels were significantly higher in cases compared to controls. Hypertensive cases also had significantly higher waist-circumference compared to the control group. The median fasting blood sugar level was significantly higher in cases compared to controls. This study established the use of Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), and Cockcroft and Gault formula (CG) as the most accurate predictive equations for assessing renal dysfunction. The threshold for NGAL above which renal impairment can be assessed was found to be 109.4 ng/ml (sen-91%, spec. – 68%), 120 ng/ml (sen- 100%, spec- 72%) and 118.6 ng/ml (sen- 83%, spec- 72%) for MDRD, CKD-EPI and CG equations respectively. The prevalence of CKD was 16.4%, 13.6% and 20.7% respectively using the MDRD, CKD-EPI and CG. Conclusion From this study, pNGAL is a better indicator of kidney impairment in the early stages of CKD as compared with sCr in general hypertensive population. |
| first_indexed | 2024-04-09T15:11:47Z |
| format | Article |
| id | doaj.art-626bf4da7f39467e9b5cc07551eef2ec |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-04-09T15:11:47Z |
| publishDate | 2023-04-01 |
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| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-626bf4da7f39467e9b5cc07551eef2ec2023-04-30T11:10:04ZengBMCBMC Nephrology1471-23692023-04-0124111010.1186/s12882-023-03120-6Diagnostic value of neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for detection of renal failure in hypertensives: a case–control study in a regional hospital in GhanaMark Danquah0William K. B. A. Owiredu1B. A. Eghan Jnr2Dorcas Serwaa3Enoch Odame Anto4Maxwell Owusu Peprah5Christian Obirikorang6Linda A. Fondjo7Department of Medical Laboratory Technology, Faculty of Applied Science and Technology, Sunyani Technical UniversityDepartment of Molecular Medicine, School of Medicine and Dentistry, Kwame Nkrumah University of Science and TechnologyDepartment of Molecular Medicine, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Ghana/Komfo Anokye Teaching HospitalDepartment of Obstetrics and Gynecology, University of MelbourneDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, Kwame Nkrumah University of Science and TechnologyDepartment of Nursing and Midwifery, Presbyterian Nursing and MidwiferyDepartment of Molecular Medicine, School of Medicine and Dentistry, Kwame Nkrumah University of Science and TechnologyDepartment of Molecular Medicine, School of Medicine and Dentistry, Kwame Nkrumah University of Science and TechnologyAbstract Background Renal failure is one of the most serious vascular effects of hypertension. For better therapy and prevention of complications, early kidney disease identification in these patients is absolutely essential. However, current studies have proposed plasma Neutrophil Gelatinase Associated Lipocalin (pNGAL) to be a better biomarker comparative to serum creatinine (SCr). This study assessed the diagnostic utility of plasma neutrophil gelatinase-associated lipocalin (pNGAL) as a biomarker for early nephropathy diagnosis in hypertensive individuals. Methods This hospital-based case–control study comprised 140 hypertensives and 70 healthy participants. A well-structured questionnaire and patient case notes were used to document relevant demographic and clinical information. 5 ml of venous blood sample was taken to measure fasting blood sugar levels, creatinine, and plasma NGAL levels. All data were analyzed using the Statistical Package for Social Sciences (SPSS release 20.0, copyrite©SPSS Inc.) and a p-value < 0.05 was considered statistically significant. Results In this study the plasma neutrophil gelatinase-associated lipocalin (NGAL) levels were significantly higher in cases compared to controls. Hypertensive cases also had significantly higher waist-circumference compared to the control group. The median fasting blood sugar level was significantly higher in cases compared to controls. This study established the use of Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), and Cockcroft and Gault formula (CG) as the most accurate predictive equations for assessing renal dysfunction. The threshold for NGAL above which renal impairment can be assessed was found to be 109.4 ng/ml (sen-91%, spec. – 68%), 120 ng/ml (sen- 100%, spec- 72%) and 118.6 ng/ml (sen- 83%, spec- 72%) for MDRD, CKD-EPI and CG equations respectively. The prevalence of CKD was 16.4%, 13.6% and 20.7% respectively using the MDRD, CKD-EPI and CG. Conclusion From this study, pNGAL is a better indicator of kidney impairment in the early stages of CKD as compared with sCr in general hypertensive population.https://doi.org/10.1186/s12882-023-03120-6HypertensionRenal failureCreatinineNeutrophil gelatinase associated lipocalin |
| spellingShingle | Mark Danquah William K. B. A. Owiredu B. A. Eghan Jnr Dorcas Serwaa Enoch Odame Anto Maxwell Owusu Peprah Christian Obirikorang Linda A. Fondjo Diagnostic value of neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for detection of renal failure in hypertensives: a case–control study in a regional hospital in Ghana BMC Nephrology Hypertension Renal failure Creatinine Neutrophil gelatinase associated lipocalin |
| title | Diagnostic value of neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for detection of renal failure in hypertensives: a case–control study in a regional hospital in Ghana |
| title_full | Diagnostic value of neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for detection of renal failure in hypertensives: a case–control study in a regional hospital in Ghana |
| title_fullStr | Diagnostic value of neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for detection of renal failure in hypertensives: a case–control study in a regional hospital in Ghana |
| title_full_unstemmed | Diagnostic value of neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for detection of renal failure in hypertensives: a case–control study in a regional hospital in Ghana |
| title_short | Diagnostic value of neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for detection of renal failure in hypertensives: a case–control study in a regional hospital in Ghana |
| title_sort | diagnostic value of neutrophil gelatinase associated lipocalin ngal as an early biomarker for detection of renal failure in hypertensives a case control study in a regional hospital in ghana |
| topic | Hypertension Renal failure Creatinine Neutrophil gelatinase associated lipocalin |
| url | https://doi.org/10.1186/s12882-023-03120-6 |
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