Histological and Ultrastructural Description of Benign Adipocytic Tumors in Farmed Striped Sea Bream (<i>Lythognathus mormyrus</i>)
Cutaneous neoplasms affecting wild striped bream (<i>Lythognathus mormyrus</i>) have been recorded after their introduction in a marine aquaculture farm in the Adriatic Sea. The tumors were evident on 24% of the reared fish, showing single or multiple nodules, with a diameter ranging bet...
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MDPI AG
2021-11-01
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| author | Massimo Orioles Marco Galeotti Pierpaolo Patarnello Stefano Pizzolitto Donatella Volpatti |
| author_facet | Massimo Orioles Marco Galeotti Pierpaolo Patarnello Stefano Pizzolitto Donatella Volpatti |
| author_sort | Massimo Orioles |
| collection | DOAJ |
| description | Cutaneous neoplasms affecting wild striped bream (<i>Lythognathus mormyrus</i>) have been recorded after their introduction in a marine aquaculture farm in the Adriatic Sea. The tumors were evident on 24% of the reared fish, showing single or multiple nodules, with a diameter ranging between 0.5–4.0 cm. Histologically, all the neoplastic lesions were located in the stratum spongiosum of the dermis and were surrounded by a thin capsule of connective tissue. The tumors were predominantly composed of adipocytes grouped and surrounded by a thin net of fibroblasts and collagen fibers. In some lipomas a mixture of adipocytes and uniform spindle cells were also observed. Fibroblasts and collagen fibers, or spindle cells, showing few mitotic figures were mainly observed in other nodules. Three of the tumors showed bands of cells with elongated nuclei. Five neoplasms differed from the classic spindle cell lipoma due to the presence of scattered giant cells. These cells presented acidophilic abundant cytoplasm with multiple hyperchromatic nuclei showing a concentric “floret-like” arrangement. The tumors were further characterized by ultrastructural observations that allowed ruling out the presence of virus-like particles within the lesions. Histological features of the masses lead to the identification of four prevalent patterns of neoplasms: lipoma, fibrolipoma, spindle cell lipoma (SCL), and atypical spindle cell-like lipoma (ASCL). The different neoplasms could arise from the transformation of mesenchymal cells of dermal origin. To the author’s knowledge, this is the first report describing key differential histological and ultrastructural features of these neoplasms in striped sea bream. |
| first_indexed | 2024-03-10T04:39:32Z |
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| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T04:39:32Z |
| publishDate | 2021-11-01 |
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| series | Animals |
| spelling | doaj.art-626dde9347e24e23ad4395a9561fadf52023-11-23T03:26:33ZengMDPI AGAnimals2076-26152021-11-011112341310.3390/ani11123413Histological and Ultrastructural Description of Benign Adipocytic Tumors in Farmed Striped Sea Bream (<i>Lythognathus mormyrus</i>)Massimo Orioles0Marco Galeotti1Pierpaolo Patarnello2Stefano Pizzolitto3Donatella Volpatti4Department of Agricultural, Food, Environmental and Animal Sciences, DI4A, University of Udine, 33100 Udine, ItalyDepartment of Agricultural, Food, Environmental and Animal Sciences, DI4A, University of Udine, 33100 Udine, ItalyDepartment of Prevention ASL Le SIAV.B Lecce Sud, 73100 Lecce, ItalyDepartment of Human Anatomic Pathology, Azienda Universitaria Integrata di Udine, University of Udine, 33100 Udine, ItalyDepartment of Agricultural, Food, Environmental and Animal Sciences, DI4A, University of Udine, 33100 Udine, ItalyCutaneous neoplasms affecting wild striped bream (<i>Lythognathus mormyrus</i>) have been recorded after their introduction in a marine aquaculture farm in the Adriatic Sea. The tumors were evident on 24% of the reared fish, showing single or multiple nodules, with a diameter ranging between 0.5–4.0 cm. Histologically, all the neoplastic lesions were located in the stratum spongiosum of the dermis and were surrounded by a thin capsule of connective tissue. The tumors were predominantly composed of adipocytes grouped and surrounded by a thin net of fibroblasts and collagen fibers. In some lipomas a mixture of adipocytes and uniform spindle cells were also observed. Fibroblasts and collagen fibers, or spindle cells, showing few mitotic figures were mainly observed in other nodules. Three of the tumors showed bands of cells with elongated nuclei. Five neoplasms differed from the classic spindle cell lipoma due to the presence of scattered giant cells. These cells presented acidophilic abundant cytoplasm with multiple hyperchromatic nuclei showing a concentric “floret-like” arrangement. The tumors were further characterized by ultrastructural observations that allowed ruling out the presence of virus-like particles within the lesions. Histological features of the masses lead to the identification of four prevalent patterns of neoplasms: lipoma, fibrolipoma, spindle cell lipoma (SCL), and atypical spindle cell-like lipoma (ASCL). The different neoplasms could arise from the transformation of mesenchymal cells of dermal origin. To the author’s knowledge, this is the first report describing key differential histological and ultrastructural features of these neoplasms in striped sea bream.https://www.mdpi.com/2076-2615/11/12/3413lipomaspindle cell lipomafibrolipomaatypical spindle cell-like lipomatumorsstriped sea bream |
| spellingShingle | Massimo Orioles Marco Galeotti Pierpaolo Patarnello Stefano Pizzolitto Donatella Volpatti Histological and Ultrastructural Description of Benign Adipocytic Tumors in Farmed Striped Sea Bream (<i>Lythognathus mormyrus</i>) Animals lipoma spindle cell lipoma fibrolipoma atypical spindle cell-like lipoma tumors striped sea bream |
| title | Histological and Ultrastructural Description of Benign Adipocytic Tumors in Farmed Striped Sea Bream (<i>Lythognathus mormyrus</i>) |
| title_full | Histological and Ultrastructural Description of Benign Adipocytic Tumors in Farmed Striped Sea Bream (<i>Lythognathus mormyrus</i>) |
| title_fullStr | Histological and Ultrastructural Description of Benign Adipocytic Tumors in Farmed Striped Sea Bream (<i>Lythognathus mormyrus</i>) |
| title_full_unstemmed | Histological and Ultrastructural Description of Benign Adipocytic Tumors in Farmed Striped Sea Bream (<i>Lythognathus mormyrus</i>) |
| title_short | Histological and Ultrastructural Description of Benign Adipocytic Tumors in Farmed Striped Sea Bream (<i>Lythognathus mormyrus</i>) |
| title_sort | histological and ultrastructural description of benign adipocytic tumors in farmed striped sea bream i lythognathus mormyrus i |
| topic | lipoma spindle cell lipoma fibrolipoma atypical spindle cell-like lipoma tumors striped sea bream |
| url | https://www.mdpi.com/2076-2615/11/12/3413 |
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