Gout/hyperuricemia reduces the risk of Alzheimer's disease: A meta‐analysis based on latest evidence
Abstract Objective Previous studies have found the potential role of gout or hyperuricemia in subsequent development of Alzheimer's disease (AD) but reported inconsistent results. We conducted the current meta‐analysis to evaluate whether an association exists between gout/ hyperuricemia and AD...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-10-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.3207 |
| _version_ | 1797660783340945408 |
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| author | Long Wang Zheng Tan Fu‐Yu Wang Wen‐Pei Wu Jun‐Cang Wu |
| author_facet | Long Wang Zheng Tan Fu‐Yu Wang Wen‐Pei Wu Jun‐Cang Wu |
| author_sort | Long Wang |
| collection | DOAJ |
| description | Abstract Objective Previous studies have found the potential role of gout or hyperuricemia in subsequent development of Alzheimer's disease (AD) but reported inconsistent results. We conducted the current meta‐analysis to evaluate whether an association exists between gout/ hyperuricemia and AD. Methods We systematically searched PubMed and EMBASE for the published cohort studies that measured the risk of AD in subject with gout/ hyperuricemia up to May 20, 2023. Data extraction was employed by two authors independently. Rev Man 5.3 and Stata 15.0 software were used to calculate the relative ratio (RR) or hazard ratio (HR) for including studies. Subgroup analysis was performed to assess the sources of heterogeneity. A random‐effects model was adopted when heterogeneity was present. The funnel plot, Begg's test, and and Egger's test were used to assess publication bias. Results After rigorous screening, seven eligible studies were included in the final analyses. Pooled results indicated that gout or hyperuricemia decreases the risk of AD (RR: 0.69, 95% CI: 0.64∼0.72), with a high heterogeneity of 93%. Subgroup analyses showed that regional distribution was the source of heterogeneity. Egger's and Begg's tests as well as visual inspection of funnel plot suggested no publication bias in the studies. Conclusion The findings suggested that gout or hyperuricemia might have a protective effect against AD. This negative correlation should be verified by more cohort studies due to the existence of substantial heterogeneity. |
| first_indexed | 2024-03-11T18:34:55Z |
| format | Article |
| id | doaj.art-626dedb8537d46e5bc50935f92dd1a1c |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-03-11T18:34:55Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-626dedb8537d46e5bc50935f92dd1a1c2023-10-13T04:20:53ZengWileyBrain and Behavior2162-32792023-10-011310n/an/a10.1002/brb3.3207Gout/hyperuricemia reduces the risk of Alzheimer's disease: A meta‐analysis based on latest evidenceLong Wang0Zheng Tan1Fu‐Yu Wang2Wen‐Pei Wu3Jun‐Cang Wu4Department of Neurology Hefei Hospital Affiliated to Anhui Medical University (The Second People's Hospital of Hefei) HefeiAnhuiChinaDepartment of Neurology Hefei Hospital Affiliated to Anhui Medical University (The Second People's Hospital of Hefei) HefeiAnhuiChinaDepartment of Pharmacy The Second People's Hospital of Hefei HefeiAnhuiChinaDepartment of Neurology Hefei Hospital Affiliated to Anhui Medical University (The Second People's Hospital of Hefei) HefeiAnhuiChinaDepartment of Neurology Hefei Hospital Affiliated to Anhui Medical University (The Second People's Hospital of Hefei) HefeiAnhuiChinaAbstract Objective Previous studies have found the potential role of gout or hyperuricemia in subsequent development of Alzheimer's disease (AD) but reported inconsistent results. We conducted the current meta‐analysis to evaluate whether an association exists between gout/ hyperuricemia and AD. Methods We systematically searched PubMed and EMBASE for the published cohort studies that measured the risk of AD in subject with gout/ hyperuricemia up to May 20, 2023. Data extraction was employed by two authors independently. Rev Man 5.3 and Stata 15.0 software were used to calculate the relative ratio (RR) or hazard ratio (HR) for including studies. Subgroup analysis was performed to assess the sources of heterogeneity. A random‐effects model was adopted when heterogeneity was present. The funnel plot, Begg's test, and and Egger's test were used to assess publication bias. Results After rigorous screening, seven eligible studies were included in the final analyses. Pooled results indicated that gout or hyperuricemia decreases the risk of AD (RR: 0.69, 95% CI: 0.64∼0.72), with a high heterogeneity of 93%. Subgroup analyses showed that regional distribution was the source of heterogeneity. Egger's and Begg's tests as well as visual inspection of funnel plot suggested no publication bias in the studies. Conclusion The findings suggested that gout or hyperuricemia might have a protective effect against AD. This negative correlation should be verified by more cohort studies due to the existence of substantial heterogeneity.https://doi.org/10.1002/brb3.3207Alzheimer's diseaseassociationgouthyperuricemiarisk |
| spellingShingle | Long Wang Zheng Tan Fu‐Yu Wang Wen‐Pei Wu Jun‐Cang Wu Gout/hyperuricemia reduces the risk of Alzheimer's disease: A meta‐analysis based on latest evidence Brain and Behavior Alzheimer's disease association gout hyperuricemia risk |
| title | Gout/hyperuricemia reduces the risk of Alzheimer's disease: A meta‐analysis based on latest evidence |
| title_full | Gout/hyperuricemia reduces the risk of Alzheimer's disease: A meta‐analysis based on latest evidence |
| title_fullStr | Gout/hyperuricemia reduces the risk of Alzheimer's disease: A meta‐analysis based on latest evidence |
| title_full_unstemmed | Gout/hyperuricemia reduces the risk of Alzheimer's disease: A meta‐analysis based on latest evidence |
| title_short | Gout/hyperuricemia reduces the risk of Alzheimer's disease: A meta‐analysis based on latest evidence |
| title_sort | gout hyperuricemia reduces the risk of alzheimer s disease a meta analysis based on latest evidence |
| topic | Alzheimer's disease association gout hyperuricemia risk |
| url | https://doi.org/10.1002/brb3.3207 |
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