Effects of Coenzyme Q<sub>10</sub> Supplementation on Oxidative Stress Markers, Inflammatory Markers, Lymphocyte Subpopulations, and Clinical Status in Dogs with Myxomatous Mitral Valve Disease
Scarce data exist on the effects of coenzyme Q<sub>10</sub> (CoQ<sub>10</sub>) supplementation in dogs with myxomatous mitral valve disease (MMVD). The purpose of this study was to investigate the effect of CoQ<sub>10</sub> supplementation on oxidative stress mark...
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MDPI AG
2022-07-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/8/1427 |
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| author | Natalia Druzhaeva Alenka Nemec Svete Gabrijela Tavčar-Kalcher Janja Babič Alojz Ihan Katka Pohar Uroš Krapež Aleksandra Domanjko Petrič |
| author_facet | Natalia Druzhaeva Alenka Nemec Svete Gabrijela Tavčar-Kalcher Janja Babič Alojz Ihan Katka Pohar Uroš Krapež Aleksandra Domanjko Petrič |
| author_sort | Natalia Druzhaeva |
| collection | DOAJ |
| description | Scarce data exist on the effects of coenzyme Q<sub>10</sub> (CoQ<sub>10</sub>) supplementation in dogs with myxomatous mitral valve disease (MMVD). The purpose of this study was to investigate the effect of CoQ<sub>10</sub> supplementation on oxidative stress markers (glutathione peroxidase, F2-isoprostanes), markers of inflammation (tumor necrosis factor-α, TNF soluble receptor II, leucocytes, and their subtypes), lymphocyte subpopulations (T helper and cytotoxic T lymphocytes, including activated T lymphocytes, and B lymphocytes), and echocardiographic and clinical parameters in dogs with MMVD. In this randomized, controlled, double-blind, longitudinal study, 43 MMVD dogs in stages ACVIM (American College of Veterinary Internal Medicine classification) B2 and ACVIM C and D (congestive heart failure (CHF)) received water-soluble coenzyme Q<sub>10</sub> (100 mg twice daily) or placebo for 3 months, and 12 non-supplemented healthy dogs served as controls. All parameters were measured before and after supplementation in MMVD dogs and once in healthy dogs. CoQ<sub>10</sub> supplementation had a positive impact on neutrophil percentage, lymphocyte percentage, and lymphocyte concentration in our cohort of dogs with CHF (ACVIM C and D). Conclusion: CoQ<sub>10</sub> as an oral supplement may have benefits in terms of decreasing inflammation in dogs with MMVD and CHF. |
| first_indexed | 2024-03-09T04:45:56Z |
| format | Article |
| id | doaj.art-626ed1fccae94561bed084c48862ce40 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T04:45:56Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-626ed1fccae94561bed084c48862ce402023-12-03T13:15:12ZengMDPI AGAntioxidants2076-39212022-07-01118142710.3390/antiox11081427Effects of Coenzyme Q<sub>10</sub> Supplementation on Oxidative Stress Markers, Inflammatory Markers, Lymphocyte Subpopulations, and Clinical Status in Dogs with Myxomatous Mitral Valve DiseaseNatalia Druzhaeva0Alenka Nemec Svete1Gabrijela Tavčar-Kalcher2Janja Babič3Alojz Ihan4Katka Pohar5Uroš Krapež6Aleksandra Domanjko Petrič7Small Animal Clinic, Veterinary Faculty, University of Ljubljana, 1000 Ljubljana, SloveniaSmall Animal Clinic, Veterinary Faculty, University of Ljubljana, 1000 Ljubljana, SloveniaInstitute of Food Safety, Feed and Environment, University of Ljubljana, 1000 Ljubljana, SloveniaInstitute of Food Safety, Feed and Environment, University of Ljubljana, 1000 Ljubljana, SloveniaInstitute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, SloveniaInstitute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, SloveniaInstitute of Poultry, Birds, Small Mammals and Reptiles, Veterinary Faculty, University of Ljubljana, 1000 Ljubljana, SloveniaSmall Animal Clinic, Veterinary Faculty, University of Ljubljana, 1000 Ljubljana, SloveniaScarce data exist on the effects of coenzyme Q<sub>10</sub> (CoQ<sub>10</sub>) supplementation in dogs with myxomatous mitral valve disease (MMVD). The purpose of this study was to investigate the effect of CoQ<sub>10</sub> supplementation on oxidative stress markers (glutathione peroxidase, F2-isoprostanes), markers of inflammation (tumor necrosis factor-α, TNF soluble receptor II, leucocytes, and their subtypes), lymphocyte subpopulations (T helper and cytotoxic T lymphocytes, including activated T lymphocytes, and B lymphocytes), and echocardiographic and clinical parameters in dogs with MMVD. In this randomized, controlled, double-blind, longitudinal study, 43 MMVD dogs in stages ACVIM (American College of Veterinary Internal Medicine classification) B2 and ACVIM C and D (congestive heart failure (CHF)) received water-soluble coenzyme Q<sub>10</sub> (100 mg twice daily) or placebo for 3 months, and 12 non-supplemented healthy dogs served as controls. All parameters were measured before and after supplementation in MMVD dogs and once in healthy dogs. CoQ<sub>10</sub> supplementation had a positive impact on neutrophil percentage, lymphocyte percentage, and lymphocyte concentration in our cohort of dogs with CHF (ACVIM C and D). Conclusion: CoQ<sub>10</sub> as an oral supplement may have benefits in terms of decreasing inflammation in dogs with MMVD and CHF.https://www.mdpi.com/2076-3921/11/8/1427coenzyme Q<sub>10</sub>ubiquinonesupplementationmyxomatous mitral valve diseasecongestive heart failuredog |
| spellingShingle | Natalia Druzhaeva Alenka Nemec Svete Gabrijela Tavčar-Kalcher Janja Babič Alojz Ihan Katka Pohar Uroš Krapež Aleksandra Domanjko Petrič Effects of Coenzyme Q<sub>10</sub> Supplementation on Oxidative Stress Markers, Inflammatory Markers, Lymphocyte Subpopulations, and Clinical Status in Dogs with Myxomatous Mitral Valve Disease Antioxidants coenzyme Q<sub>10</sub> ubiquinone supplementation myxomatous mitral valve disease congestive heart failure dog |
| title | Effects of Coenzyme Q<sub>10</sub> Supplementation on Oxidative Stress Markers, Inflammatory Markers, Lymphocyte Subpopulations, and Clinical Status in Dogs with Myxomatous Mitral Valve Disease |
| title_full | Effects of Coenzyme Q<sub>10</sub> Supplementation on Oxidative Stress Markers, Inflammatory Markers, Lymphocyte Subpopulations, and Clinical Status in Dogs with Myxomatous Mitral Valve Disease |
| title_fullStr | Effects of Coenzyme Q<sub>10</sub> Supplementation on Oxidative Stress Markers, Inflammatory Markers, Lymphocyte Subpopulations, and Clinical Status in Dogs with Myxomatous Mitral Valve Disease |
| title_full_unstemmed | Effects of Coenzyme Q<sub>10</sub> Supplementation on Oxidative Stress Markers, Inflammatory Markers, Lymphocyte Subpopulations, and Clinical Status in Dogs with Myxomatous Mitral Valve Disease |
| title_short | Effects of Coenzyme Q<sub>10</sub> Supplementation on Oxidative Stress Markers, Inflammatory Markers, Lymphocyte Subpopulations, and Clinical Status in Dogs with Myxomatous Mitral Valve Disease |
| title_sort | effects of coenzyme q sub 10 sub supplementation on oxidative stress markers inflammatory markers lymphocyte subpopulations and clinical status in dogs with myxomatous mitral valve disease |
| topic | coenzyme Q<sub>10</sub> ubiquinone supplementation myxomatous mitral valve disease congestive heart failure dog |
| url | https://www.mdpi.com/2076-3921/11/8/1427 |
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