Demyelinating syndrome in SLE: review of different disease subtypes and report of a case series
Demyelinating syndrome (DS) is a rare manifestation of systemic lupus erythematosus (SLE) (1%) with high clinical heterogeneity and potentially severe prognosis. It can represent a diagnostic and therapeutic challenge for clinicians. A recent study described 5 different patterns of demyelinating dis...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2017-12-01
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| Series: | Reumatismo |
| Subjects: | |
| Online Access: | http://reumatismo.org/index.php/reuma/article/view/1007 |
| _version_ | 1811291263033409536 |
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| author | E. Chessa M. Piga A. Floris A. Mathieu A. Cauli |
| author_facet | E. Chessa M. Piga A. Floris A. Mathieu A. Cauli |
| author_sort | E. Chessa |
| collection | DOAJ |
| description | Demyelinating syndrome (DS) is a rare manifestation of systemic lupus erythematosus (SLE) (1%) with high clinical heterogeneity and potentially severe prognosis. It can represent a diagnostic and therapeutic challenge for clinicians. A recent study described 5 different patterns of demyelinating disease presentation, characterised by specific clinical, laboratory and brain and spine magnetic resonance imaging abnormalities: 1) neuromyelitis optica; 2) neuromyelitis optica spectrum disorders; 3) DS prevalently involving the brain; 4) DS prevalently involving the brainstem; 5) clinically isolated syndrome. In this review we briefly discuss typical characteristics of each DS presentation in SLE and we describe 5 illustrative clinical cases, one for each subset of DS, considering both diagnostic and therapeutic options. |
| first_indexed | 2024-04-13T04:26:49Z |
| format | Article |
| id | doaj.art-62718f03654240a69c748070db31ccfb |
| institution | Directory Open Access Journal |
| issn | 0048-7449 2240-2683 |
| language | English |
| last_indexed | 2024-04-13T04:26:49Z |
| publishDate | 2017-12-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Reumatismo |
| spelling | doaj.art-62718f03654240a69c748070db31ccfb2022-12-22T03:02:28ZengPAGEPress PublicationsReumatismo0048-74492240-26832017-12-0169417518310.4081/reumatismo.2017.1007762Demyelinating syndrome in SLE: review of different disease subtypes and report of a case seriesE. Chessa0M. Piga1A. Floris2A. Mathieu3A. Cauli4Rheumatology Unit, University Clinic AOU of CagliariRheumatology Unit, University Clinic AOU of CagliariRheumatology Unit, University Clinic AOU of CagliariRheumatology Unit, University Clinic AOU of CagliariRheumatology Unit, University Clinic AOU of CagliariDemyelinating syndrome (DS) is a rare manifestation of systemic lupus erythematosus (SLE) (1%) with high clinical heterogeneity and potentially severe prognosis. It can represent a diagnostic and therapeutic challenge for clinicians. A recent study described 5 different patterns of demyelinating disease presentation, characterised by specific clinical, laboratory and brain and spine magnetic resonance imaging abnormalities: 1) neuromyelitis optica; 2) neuromyelitis optica spectrum disorders; 3) DS prevalently involving the brain; 4) DS prevalently involving the brainstem; 5) clinically isolated syndrome. In this review we briefly discuss typical characteristics of each DS presentation in SLE and we describe 5 illustrative clinical cases, one for each subset of DS, considering both diagnostic and therapeutic options.http://reumatismo.org/index.php/reuma/article/view/1007Systemic lupus erythematosusDemyelinating syndromeNeuropsychiatric lupusMagnetic resonance. |
| spellingShingle | E. Chessa M. Piga A. Floris A. Mathieu A. Cauli Demyelinating syndrome in SLE: review of different disease subtypes and report of a case series Reumatismo Systemic lupus erythematosus Demyelinating syndrome Neuropsychiatric lupus Magnetic resonance. |
| title | Demyelinating syndrome in SLE: review of different disease subtypes and report of a case series |
| title_full | Demyelinating syndrome in SLE: review of different disease subtypes and report of a case series |
| title_fullStr | Demyelinating syndrome in SLE: review of different disease subtypes and report of a case series |
| title_full_unstemmed | Demyelinating syndrome in SLE: review of different disease subtypes and report of a case series |
| title_short | Demyelinating syndrome in SLE: review of different disease subtypes and report of a case series |
| title_sort | demyelinating syndrome in sle review of different disease subtypes and report of a case series |
| topic | Systemic lupus erythematosus Demyelinating syndrome Neuropsychiatric lupus Magnetic resonance. |
| url | http://reumatismo.org/index.php/reuma/article/view/1007 |
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