Lactose-Gated Mesoporous Silica Particles for Intestinal Controlled Delivery of Essential Oil Components: An In Vitro and In Vivo Study

Lactose-Gated Mesoporous Silica Particles for Intestinal Controlled Delivery of Essential Oil Components: An In Vitro and In Vivo Study

Mesoporous silica microparticles functionalized with lactose for the specific release of essential oil components (EOCs) in the small intestine are presented. In vitro and in vivo intestinal models were applied to validate the microparticles (M41-EOC-L), in which the presence of lactase acts as the...

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Bibliographic Details
Main Authors: Elisa Poyatos-Racionero, Isabel González-Álvarez, Paola Sánchez-Moreno, Leopoldo Sitia, Francesca Gatto, Pier Paolo Pompa, Elena Aznar, Marta González-Álvarez, Ramón Martínez-Máñez, María Dolores Marcos, Andrea Bernardos
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceutics
Subjects:
essential oil components
mesoporous silica microparticles
controlled release
small intestine
in vitro and in vivo intestinal models
lactase enzyme
Online Access:https://www.mdpi.com/1999-4923/13/7/982

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