Resistin Enhances VCAM-1 Expression and Monocyte Adhesion in Human Osteoarthritis Synovial Fibroblasts by Inhibiting MiR-381 Expression through the PKC, p38, and JNK Signaling Pathways

Resistin Enhances VCAM-1 Expression and Monocyte Adhesion in Human Osteoarthritis Synovial Fibroblasts by Inhibiting MiR-381 Expression through the PKC, p38, and JNK Signaling Pathways

The development of osteoarthritis (OA) is characterized by synovial inflammation and the upregulation of vascular cell adhesion molecule type 1 (VCAM-1) in human osteoarthritis synovial fibroblasts (OASFs). This increase in VCAM-1 expression promotes monocyte adhesion to OASFs. The adipokine resisti...

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Bibliographic Details
Main Authors: Wei-Cheng Chen, Chih-Yang Lin, Shu-Jui Kuo, Shan-Chi Liu, Yung-Chang Lu, Yen-Ling Chen, Shih-Wei Wang, Chih-Hsin Tang
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cells
Subjects:
osteoarthritis
resistin
VCAM-1
miR-381
monocytes
Online Access:https://www.mdpi.com/2073-4409/9/6/1369

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