Diabetic Corneal Neuropathy: Pathogenic Mechanisms and Therapeutic Strategies
Diabetes mellitus (DM) is a major global public health problem that can cause complications such as diabetic retinopathy, diabetic neuropathy, and diabetic nephropathy. Besides the reporting of reduction in corneal nerve density and decrease in corneal sensitivity in diabetic patients, there may be...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.816062/full |
| _version_ | 1818979830589292544 |
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| author | Ting Zhou Allie Lee Amy Cheuk Yin Lo Jeremy Sze Wai John Kwok |
| author_facet | Ting Zhou Allie Lee Amy Cheuk Yin Lo Jeremy Sze Wai John Kwok |
| author_sort | Ting Zhou |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is a major global public health problem that can cause complications such as diabetic retinopathy, diabetic neuropathy, and diabetic nephropathy. Besides the reporting of reduction in corneal nerve density and decrease in corneal sensitivity in diabetic patients, there may be a subsequent result in delayed corneal wound healing and increased corneal infections. Despite being a potential cause of blindness, these corneal nerve changes have not gained enough attention. It has been proposed that corneal nerve changes may be an indicator for diabetic neuropathy, which can provide a window for early diagnosis and treatment. In this review, the authors aimed to give an overview of the relationship between corneal nerves and diabetic neuropathy as well as the underlying pathophysiological mechanisms of corneal nerve fiber changes caused by DM for improved prediction and prevention of diabetic neuropathy. In addition, the authors summarized current and novel therapeutic methods for delayed corneal wound healing, nerve protection and regeneration in the diabetic cornea. |
| first_indexed | 2024-12-20T17:05:46Z |
| format | Article |
| id | doaj.art-627463a6ec04400a944f4a039d68bd8a |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-20T17:05:46Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-627463a6ec04400a944f4a039d68bd8a2022-12-21T19:32:18ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-02-011310.3389/fphar.2022.816062816062Diabetic Corneal Neuropathy: Pathogenic Mechanisms and Therapeutic StrategiesTing ZhouAllie LeeAmy Cheuk Yin LoJeremy Sze Wai John KwokDiabetes mellitus (DM) is a major global public health problem that can cause complications such as diabetic retinopathy, diabetic neuropathy, and diabetic nephropathy. Besides the reporting of reduction in corneal nerve density and decrease in corneal sensitivity in diabetic patients, there may be a subsequent result in delayed corneal wound healing and increased corneal infections. Despite being a potential cause of blindness, these corneal nerve changes have not gained enough attention. It has been proposed that corneal nerve changes may be an indicator for diabetic neuropathy, which can provide a window for early diagnosis and treatment. In this review, the authors aimed to give an overview of the relationship between corneal nerves and diabetic neuropathy as well as the underlying pathophysiological mechanisms of corneal nerve fiber changes caused by DM for improved prediction and prevention of diabetic neuropathy. In addition, the authors summarized current and novel therapeutic methods for delayed corneal wound healing, nerve protection and regeneration in the diabetic cornea.https://www.frontiersin.org/articles/10.3389/fphar.2022.816062/fullcorneal nerve damagecorneal confocal microscopydiabetic complicationsdry eyenerve regenerationocular disease |
| spellingShingle | Ting Zhou Allie Lee Amy Cheuk Yin Lo Jeremy Sze Wai John Kwok Diabetic Corneal Neuropathy: Pathogenic Mechanisms and Therapeutic Strategies Frontiers in Pharmacology corneal nerve damage corneal confocal microscopy diabetic complications dry eye nerve regeneration ocular disease |
| title | Diabetic Corneal Neuropathy: Pathogenic Mechanisms and Therapeutic Strategies |
| title_full | Diabetic Corneal Neuropathy: Pathogenic Mechanisms and Therapeutic Strategies |
| title_fullStr | Diabetic Corneal Neuropathy: Pathogenic Mechanisms and Therapeutic Strategies |
| title_full_unstemmed | Diabetic Corneal Neuropathy: Pathogenic Mechanisms and Therapeutic Strategies |
| title_short | Diabetic Corneal Neuropathy: Pathogenic Mechanisms and Therapeutic Strategies |
| title_sort | diabetic corneal neuropathy pathogenic mechanisms and therapeutic strategies |
| topic | corneal nerve damage corneal confocal microscopy diabetic complications dry eye nerve regeneration ocular disease |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.816062/full |
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