The effects of bare metal versus drug-eluting stent implantation on circulating endothelial cells following percutaneous coronary intervention FNx01
Background: The purpose of this study was to compare the effects of bare metal stents (BMS) and drug-eluting stents (DES) implantation on circulating endothelial cells (CECs) which have been proposed as cellular markers of endothelial dysfunction following percutaneous coronary intervention (PCI). R...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-01-01
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| Series: | Journal of Research in Medical Sciences |
| Subjects: | |
| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2011;volume=16;issue=5;spage=605;epage=610;aulast=Jazi |
| _version_ | 1818250498263744512 |
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| author | Seyed Hashemi Jazi Saeed Shafiei Seyed Hamid Zarkesh-Esfahani Saman Maleki Vareki Shaghayegh Haghjooy Javanmard |
| author_facet | Seyed Hashemi Jazi Saeed Shafiei Seyed Hamid Zarkesh-Esfahani Saman Maleki Vareki Shaghayegh Haghjooy Javanmard |
| author_sort | Seyed Hashemi Jazi |
| collection | DOAJ |
| description | Background: The purpose of this study was to compare the effects of bare metal stents (BMS) and drug-eluting stents (DES) implantation on circulating endothelial cells (CECs) which have been proposed as cellular markers of endothelial dysfunction following percutaneous coronary intervention (PCI). Recently, it has been established that DES further reduce restenosis and revascularization rate compared to bare metal stents in elective procedures. However, its benefits are compromised by the stent-related thrombosis events.
Methods: 22 patients who were candidate of PCI were included in this study. The patients underwent DES implantation (n = 11) or BMS implantation (n = 11). In all patients the numbers of CECs were determined before and a week after stent implantation using flow cytometry and the obtained data were compared within and between groups by paired and unpaired Student′s t-test, respectively. CECs were defined as cells negative for CD45 (FITC) and highly double positive for CD146 (PE) and CD34 (PE-Cy5) expression.
Results: There were no significant differences in the baseline levels of CECs between two groups (p = 0.96). Stent implantation led to a significant increase in CECs compared with the preprocedural levels in the BMS group (p = 0.005) whereas there was a significant decrease in CEC numbers in DES group (p < 0.001). One week after stent implantation CECs count in BMS group was significantly higher compared to DES group (p < 0.001).
Conclusions: The results indicate that patients undergoing DES implantation were subjected to less endothelial injury than patients receiving BMS as indicated by CEC enumeration. |
| first_indexed | 2024-12-12T15:53:20Z |
| format | Article |
| id | doaj.art-62746edf4e224b18b196bf773e0a07e8 |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-12-12T15:53:20Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-62746edf4e224b18b196bf773e0a07e82022-12-22T00:19:32ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362011-01-01165605610The effects of bare metal versus drug-eluting stent implantation on circulating endothelial cells following percutaneous coronary intervention FNx01Seyed Hashemi JaziSaeed ShafieiSeyed Hamid Zarkesh-EsfahaniSaman Maleki VarekiShaghayegh Haghjooy JavanmardBackground: The purpose of this study was to compare the effects of bare metal stents (BMS) and drug-eluting stents (DES) implantation on circulating endothelial cells (CECs) which have been proposed as cellular markers of endothelial dysfunction following percutaneous coronary intervention (PCI). Recently, it has been established that DES further reduce restenosis and revascularization rate compared to bare metal stents in elective procedures. However, its benefits are compromised by the stent-related thrombosis events. Methods: 22 patients who were candidate of PCI were included in this study. The patients underwent DES implantation (n = 11) or BMS implantation (n = 11). In all patients the numbers of CECs were determined before and a week after stent implantation using flow cytometry and the obtained data were compared within and between groups by paired and unpaired Student′s t-test, respectively. CECs were defined as cells negative for CD45 (FITC) and highly double positive for CD146 (PE) and CD34 (PE-Cy5) expression. Results: There were no significant differences in the baseline levels of CECs between two groups (p = 0.96). Stent implantation led to a significant increase in CECs compared with the preprocedural levels in the BMS group (p = 0.005) whereas there was a significant decrease in CEC numbers in DES group (p < 0.001). One week after stent implantation CECs count in BMS group was significantly higher compared to DES group (p < 0.001). Conclusions: The results indicate that patients undergoing DES implantation were subjected to less endothelial injury than patients receiving BMS as indicated by CEC enumeration.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2011;volume=16;issue=5;spage=605;epage=610;aulast=JaziAngioplastyBalloonCoronaryDrug-Eluting StentsEndothelial Cells |
| spellingShingle | Seyed Hashemi Jazi Saeed Shafiei Seyed Hamid Zarkesh-Esfahani Saman Maleki Vareki Shaghayegh Haghjooy Javanmard The effects of bare metal versus drug-eluting stent implantation on circulating endothelial cells following percutaneous coronary intervention FNx01 Journal of Research in Medical Sciences Angioplasty Balloon Coronary Drug-Eluting Stents Endothelial Cells |
| title | The effects of bare metal versus drug-eluting stent implantation on circulating endothelial cells following percutaneous coronary intervention FNx01 |
| title_full | The effects of bare metal versus drug-eluting stent implantation on circulating endothelial cells following percutaneous coronary intervention FNx01 |
| title_fullStr | The effects of bare metal versus drug-eluting stent implantation on circulating endothelial cells following percutaneous coronary intervention FNx01 |
| title_full_unstemmed | The effects of bare metal versus drug-eluting stent implantation on circulating endothelial cells following percutaneous coronary intervention FNx01 |
| title_short | The effects of bare metal versus drug-eluting stent implantation on circulating endothelial cells following percutaneous coronary intervention FNx01 |
| title_sort | effects of bare metal versus drug eluting stent implantation on circulating endothelial cells following percutaneous coronary intervention fnx01 |
| topic | Angioplasty Balloon Coronary Drug-Eluting Stents Endothelial Cells |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2011;volume=16;issue=5;spage=605;epage=610;aulast=Jazi |
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