SO2 Donors and Prodrugs, and Their Possible Applications: A Review
SO2 is widely recognized as an air pollutant and is a known cause of acid rain. At a sufficiently high level, it also causes respiratory diseases. A much lesser known side of SO2 is its endogenous nature and possible physiological roles. There is mounting evidence that SO2 is produced during normal...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-11-01
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| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fchem.2018.00559/full |
| _version_ | 1819169911732174848 |
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| author | Wenyi Wang Binghe Wang |
| author_facet | Wenyi Wang Binghe Wang |
| author_sort | Wenyi Wang |
| collection | DOAJ |
| description | SO2 is widely recognized as an air pollutant and is a known cause of acid rain. At a sufficiently high level, it also causes respiratory diseases. A much lesser known side of SO2 is its endogenous nature and possible physiological roles. There is mounting evidence that SO2 is produced during normal cellular metabolism and may possibly function as a signaling molecule in normal physiology. The latter aspect is still at the stage of being carefully examined as to the validity of classifying SO2 as a gasotransmitter with endogenous signaling roles. One difficulty in studying the biological and pharmacological roles of SO2 is the lack of adequate tools for its controllable and precise delivery. Traditional methods of using SO2 gas or mixed sulfite salts do not meet research need for several reasons. Therefore, there has been increasing attention on the need of developing SO2 donors or prodrugs that can be used as tools for the elucidation of SO2's physiological roles, pharmacological effects, and possible mechanism(s) of action. In this review, we aim to review basic sulfur chemistry in the context of sulfur signaling and various chemical strategies used for designing SO2 donors. We will also discuss potential pharmacological applications of SO2 donors, lay out desirable features for such donors and possibly prodrugs, analyze existing problems, and give our thoughts on research needs. |
| first_indexed | 2024-12-22T19:27:01Z |
| format | Article |
| id | doaj.art-6274829a4c804482804b00a608e6436d |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-22T19:27:01Z |
| publishDate | 2018-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-6274829a4c804482804b00a608e6436d2022-12-21T18:15:13ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462018-11-01610.3389/fchem.2018.00559419374SO2 Donors and Prodrugs, and Their Possible Applications: A ReviewWenyi WangBinghe WangSO2 is widely recognized as an air pollutant and is a known cause of acid rain. At a sufficiently high level, it also causes respiratory diseases. A much lesser known side of SO2 is its endogenous nature and possible physiological roles. There is mounting evidence that SO2 is produced during normal cellular metabolism and may possibly function as a signaling molecule in normal physiology. The latter aspect is still at the stage of being carefully examined as to the validity of classifying SO2 as a gasotransmitter with endogenous signaling roles. One difficulty in studying the biological and pharmacological roles of SO2 is the lack of adequate tools for its controllable and precise delivery. Traditional methods of using SO2 gas or mixed sulfite salts do not meet research need for several reasons. Therefore, there has been increasing attention on the need of developing SO2 donors or prodrugs that can be used as tools for the elucidation of SO2's physiological roles, pharmacological effects, and possible mechanism(s) of action. In this review, we aim to review basic sulfur chemistry in the context of sulfur signaling and various chemical strategies used for designing SO2 donors. We will also discuss potential pharmacological applications of SO2 donors, lay out desirable features for such donors and possibly prodrugs, analyze existing problems, and give our thoughts on research needs.https://www.frontiersin.org/article/10.3389/fchem.2018.00559/fullsulfur dioxidegasotransmittersdonorsprodrugsapplications |
| spellingShingle | Wenyi Wang Binghe Wang SO2 Donors and Prodrugs, and Their Possible Applications: A Review Frontiers in Chemistry sulfur dioxide gasotransmitters donors prodrugs applications |
| title | SO2 Donors and Prodrugs, and Their Possible Applications: A Review |
| title_full | SO2 Donors and Prodrugs, and Their Possible Applications: A Review |
| title_fullStr | SO2 Donors and Prodrugs, and Their Possible Applications: A Review |
| title_full_unstemmed | SO2 Donors and Prodrugs, and Their Possible Applications: A Review |
| title_short | SO2 Donors and Prodrugs, and Their Possible Applications: A Review |
| title_sort | so2 donors and prodrugs and their possible applications a review |
| topic | sulfur dioxide gasotransmitters donors prodrugs applications |
| url | https://www.frontiersin.org/article/10.3389/fchem.2018.00559/full |
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