Metabolic Regulation of Redox Balance in Cancer
Reactive oxygen species (ROS) are chemically active free radicals produced by partial reduction of oxygen that can activate discrete signaling pathways or disrupt redox homeostasis depending on their concentration. ROS interacts with biomolecules, including DNA, and can cause mutations that can tran...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-07-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/11/7/955 |
| _version_ | 1797725880458412032 |
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| author | Vinee Purohit Diane M. Simeone Costas A. Lyssiotis |
| author_facet | Vinee Purohit Diane M. Simeone Costas A. Lyssiotis |
| author_sort | Vinee Purohit |
| collection | DOAJ |
| description | Reactive oxygen species (ROS) are chemically active free radicals produced by partial reduction of oxygen that can activate discrete signaling pathways or disrupt redox homeostasis depending on their concentration. ROS interacts with biomolecules, including DNA, and can cause mutations that can transform normal cells into cancer cells. Furthermore, certain cancer-causing mutations trigger alterations in cellular metabolism that can increase ROS production, resulting in genomic instability, additional DNA mutations, and tumor evolution. To prevent excess ROS-mediated toxicity, cancer-causing mutations concurrently activate pathways that manage this oxidative burden. Hence, an understanding of the metabolic pathways that regulate ROS levels is imperative for devising therapies that target tumor cells. In this review, we summarize the dual role of metabolism as a generator and inhibitor of ROS in cancer and discuss current strategies to target the ROS axis. |
| first_indexed | 2024-03-12T10:37:40Z |
| format | Article |
| id | doaj.art-62748429084a4c2e9bc793aa9376198b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T10:37:40Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-62748429084a4c2e9bc793aa9376198b2023-09-02T08:29:40ZengMDPI AGCancers2072-66942019-07-0111795510.3390/cancers11070955cancers11070955Metabolic Regulation of Redox Balance in CancerVinee Purohit0Diane M. Simeone1Costas A. Lyssiotis2Perlmutter Cancer Center, New York University, New York, NY 10016, USAPerlmutter Cancer Center, New York University, New York, NY 10016, USADepartments of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USAReactive oxygen species (ROS) are chemically active free radicals produced by partial reduction of oxygen that can activate discrete signaling pathways or disrupt redox homeostasis depending on their concentration. ROS interacts with biomolecules, including DNA, and can cause mutations that can transform normal cells into cancer cells. Furthermore, certain cancer-causing mutations trigger alterations in cellular metabolism that can increase ROS production, resulting in genomic instability, additional DNA mutations, and tumor evolution. To prevent excess ROS-mediated toxicity, cancer-causing mutations concurrently activate pathways that manage this oxidative burden. Hence, an understanding of the metabolic pathways that regulate ROS levels is imperative for devising therapies that target tumor cells. In this review, we summarize the dual role of metabolism as a generator and inhibitor of ROS in cancer and discuss current strategies to target the ROS axis.https://www.mdpi.com/2072-6694/11/7/955oxidative stressantioxidantsROSNADPH |
| spellingShingle | Vinee Purohit Diane M. Simeone Costas A. Lyssiotis Metabolic Regulation of Redox Balance in Cancer Cancers oxidative stress antioxidants ROS NADPH |
| title | Metabolic Regulation of Redox Balance in Cancer |
| title_full | Metabolic Regulation of Redox Balance in Cancer |
| title_fullStr | Metabolic Regulation of Redox Balance in Cancer |
| title_full_unstemmed | Metabolic Regulation of Redox Balance in Cancer |
| title_short | Metabolic Regulation of Redox Balance in Cancer |
| title_sort | metabolic regulation of redox balance in cancer |
| topic | oxidative stress antioxidants ROS NADPH |
| url | https://www.mdpi.com/2072-6694/11/7/955 |
| work_keys_str_mv | AT vineepurohit metabolicregulationofredoxbalanceincancer AT dianemsimeone metabolicregulationofredoxbalanceincancer AT costasalyssiotis metabolicregulationofredoxbalanceincancer |