Involvement and possible role of transglutaminases 1 and 2 in mediating fibrotic signalling, collagen cross-linking and cell proliferation in neonatal rat ventricular fibroblasts.

Involvement and possible role of transglutaminases 1 and 2 in mediating fibrotic signalling, collagen cross-linking and cell proliferation in neonatal rat ventricular fibroblasts.

Transglutaminase (TG) isoforms control diverse normal and pathophysiologic processes through their capacity to cross-link extracellular matrix (ECM) proteins. Their functional and signalling roles in cardiac fibrosis remain poorly understood, despite some evidence of TG2 involvement in abnormal ECM...

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Main Authors: Doa'a G F Al-U'datt, Carole C Tranchant, Belal Al-Husein, Roddy Hiram, Ahmed Al-Dwairi, Mohammad AlQudah, Othman Al-Shboul, Saied Jaradat, Jenan Alqbelat, Ali Almajwal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0281320

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https://doi.org/10.1371/journal.pone.0281320

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