The role of zyxin in signal transduction and its relationship with diseases
This review highlighted the pivotal role of zyxin, an essential cell focal adhesions protein, in cellular biology and various diseases. Zyxin can orchestrate the restructuring and dynamic alterations of the cellular cytoskeleton, which is involved in cell proliferation, adhesion, motility, and gene...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2024.1371549/full |
| _version_ | 1827276570747731968 |
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| author | Zelan Wu Daiqin Wu Qin Zhong Xue Zou Zhongjing Liu Hehua Long Jing Wei Xia Li Fangjie Dai |
| author_facet | Zelan Wu Daiqin Wu Qin Zhong Xue Zou Zhongjing Liu Hehua Long Jing Wei Xia Li Fangjie Dai |
| author_sort | Zelan Wu |
| collection | DOAJ |
| description | This review highlighted the pivotal role of zyxin, an essential cell focal adhesions protein, in cellular biology and various diseases. Zyxin can orchestrate the restructuring and dynamic alterations of the cellular cytoskeleton, which is involved in cell proliferation, adhesion, motility, and gene transcription. Aberrant zyxin expression is closely correlated with tumor cell activity and cardiac function in both tumorigenesis and cardiovascular diseases. Moreover, in fibrotic and inflammatory conditions, zyxin can modulate cellular functions and inflammatory responses. Therefore, a comprehensive understanding of zyxin is crucial for deciphering signal transduction networks and disease pathogenesis. Investigating its role in diseases holds promise for novel avenues in early diagnosis and therapeutic strategies. Nevertheless, targeting zyxin as a therapeutic focal point presents challenges in terms of specificity, safety, drug delivery, and resistance. Nonetheless, in-depth studies on zyxin and the application of precision medicine could offer new possibilities for personalized treatment modalities. |
| first_indexed | 2024-04-24T07:01:59Z |
| format | Article |
| id | doaj.art-62766926cc83427f9d3c4e649b86a4c0 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-04-24T07:01:59Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-62766926cc83427f9d3c4e649b86a4c02024-04-22T06:54:15ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2024-04-011110.3389/fmolb.2024.13715491371549The role of zyxin in signal transduction and its relationship with diseasesZelan Wu0Daiqin Wu1Qin Zhong2Xue Zou3Zhongjing Liu4Hehua Long5Jing Wei6Xia Li7Fangjie Dai8Department of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaDepartment of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaClinical Research Center, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaClinical Research Center, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaClinical Research Center, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaSchool of Clinical Laboratory Science, Guizhou Medical University, Guiyang, ChinaDepartment of Endocrinology, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaGuizhou Precision Medicine Institute, Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaDepartment of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaThis review highlighted the pivotal role of zyxin, an essential cell focal adhesions protein, in cellular biology and various diseases. Zyxin can orchestrate the restructuring and dynamic alterations of the cellular cytoskeleton, which is involved in cell proliferation, adhesion, motility, and gene transcription. Aberrant zyxin expression is closely correlated with tumor cell activity and cardiac function in both tumorigenesis and cardiovascular diseases. Moreover, in fibrotic and inflammatory conditions, zyxin can modulate cellular functions and inflammatory responses. Therefore, a comprehensive understanding of zyxin is crucial for deciphering signal transduction networks and disease pathogenesis. Investigating its role in diseases holds promise for novel avenues in early diagnosis and therapeutic strategies. Nevertheless, targeting zyxin as a therapeutic focal point presents challenges in terms of specificity, safety, drug delivery, and resistance. Nonetheless, in-depth studies on zyxin and the application of precision medicine could offer new possibilities for personalized treatment modalities.https://www.frontiersin.org/articles/10.3389/fmolb.2024.1371549/fullzyxintumorigenesiscardiovascular diseasesinflammatory responsessignal transduction networks |
| spellingShingle | Zelan Wu Daiqin Wu Qin Zhong Xue Zou Zhongjing Liu Hehua Long Jing Wei Xia Li Fangjie Dai The role of zyxin in signal transduction and its relationship with diseases Frontiers in Molecular Biosciences zyxin tumorigenesis cardiovascular diseases inflammatory responses signal transduction networks |
| title | The role of zyxin in signal transduction and its relationship with diseases |
| title_full | The role of zyxin in signal transduction and its relationship with diseases |
| title_fullStr | The role of zyxin in signal transduction and its relationship with diseases |
| title_full_unstemmed | The role of zyxin in signal transduction and its relationship with diseases |
| title_short | The role of zyxin in signal transduction and its relationship with diseases |
| title_sort | role of zyxin in signal transduction and its relationship with diseases |
| topic | zyxin tumorigenesis cardiovascular diseases inflammatory responses signal transduction networks |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2024.1371549/full |
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