Association of the systemic immuno-inflammation index, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio with diabetic microvascular complications
BackgroundThe systemic immuno-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are widely used and have been shown to be predictive indicators of various diseases. Diabetic nephropathy (DN), retinopathy (DR), and peripheral neuropathy (DPN) are t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1367376/full |
| _version_ | 1797215826012536832 |
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| author | Jiahang Li Xueying Wang Wenjing Jia Wenjing Jia Kai Wang Kai Wang Wenju Wang Weibo Diao Feiya Ou Jing Ma Yan Yang Yan Yang |
| author_facet | Jiahang Li Xueying Wang Wenjing Jia Wenjing Jia Kai Wang Kai Wang Wenju Wang Weibo Diao Feiya Ou Jing Ma Yan Yang Yan Yang |
| author_sort | Jiahang Li |
| collection | DOAJ |
| description | BackgroundThe systemic immuno-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are widely used and have been shown to be predictive indicators of various diseases. Diabetic nephropathy (DN), retinopathy (DR), and peripheral neuropathy (DPN) are the most prominent and common microvascular complications, which have seriously negative impacts on patients, families, and society. Exploring the associations with these three indicators and diabetic microvascular complications are the main purpose.MethodsThere were 1058 individuals with type 2 diabetes mellitus (T2DM) in this retrospective cross-sectional study. SII, NLR, and PLR were calculated. The diseases were diagnosed by endocrinologists. Logistic regression and subgroup analysis were applied to evaluate the association between SII, NLP, and PLR and diabetic microvascular complications.ResultsSII, NLR, and PLR were significantly associated with the risk of DN [odds ratios (ORs): 1.52, 1.71, and 1.60, respectively] and DR [ORs: 1.57, 1.79, and 1.55, respectively] by multivariate logistic regression. When NLR ≥2.66, the OR was significantly higher for the risk of DPN (OR: 1.985, 95% confidence interval: 1.29–3.05). Subgroup analysis showed no significant positive associations across different demographics and comorbidities, including sex, age, hypertension, HbA1c (glycated hemoglobin), and dyslipidemia.ConclusionThis study found a positive relationship between NLR and DN, DR, and DPN. In contrast, SII and PLR were found to be only associated with DN and DR. Therefore, for the diagnosis of diabetic microvascular complications, SII, NLR and PLR are highly valuable. |
| first_indexed | 2024-04-24T11:36:14Z |
| format | Article |
| id | doaj.art-627714435fde4dd49a25ed79c30d4609 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-24T11:36:14Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-627714435fde4dd49a25ed79c30d46092024-04-10T05:11:51ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-04-011510.3389/fendo.2024.13673761367376Association of the systemic immuno-inflammation index, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio with diabetic microvascular complicationsJiahang Li0Xueying Wang1Wenjing Jia2Wenjing Jia3Kai Wang4Kai Wang5Wenju Wang6Weibo Diao7Feiya Ou8Jing Ma9Yan Yang10Yan Yang11Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi’an, ChinaDepartment of Traditional Chinese Medicine, The First Affiliated Hospital-of Air Force Medical University, Xi’an, ChinaDepartment of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi’an, ChinaDepartment of Pharmacy, The Hospital of Traditional Chinese Medicine in Changwu Country, Changwu, ChinaDepartment of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi’an, ChinaDepartment of Pharmacy, Sanya Rehabilitation and Recuperation Center, Joint Logistics Support Force, People's Liberation Army, Sanya, ChinaDepartment of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi’an, ChinaDepartment of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi’an, ChinaDepartment of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi’an, ChinaDepartment of Traditional Chinese Medicine, The First Affiliated Hospital-of Air Force Medical University, Xi’an, ChinaDepartment of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi’an, ChinaDepartment of Traditional Chinese Medicine, The First Affiliated Hospital-of Air Force Medical University, Xi’an, ChinaBackgroundThe systemic immuno-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are widely used and have been shown to be predictive indicators of various diseases. Diabetic nephropathy (DN), retinopathy (DR), and peripheral neuropathy (DPN) are the most prominent and common microvascular complications, which have seriously negative impacts on patients, families, and society. Exploring the associations with these three indicators and diabetic microvascular complications are the main purpose.MethodsThere were 1058 individuals with type 2 diabetes mellitus (T2DM) in this retrospective cross-sectional study. SII, NLR, and PLR were calculated. The diseases were diagnosed by endocrinologists. Logistic regression and subgroup analysis were applied to evaluate the association between SII, NLP, and PLR and diabetic microvascular complications.ResultsSII, NLR, and PLR were significantly associated with the risk of DN [odds ratios (ORs): 1.52, 1.71, and 1.60, respectively] and DR [ORs: 1.57, 1.79, and 1.55, respectively] by multivariate logistic regression. When NLR ≥2.66, the OR was significantly higher for the risk of DPN (OR: 1.985, 95% confidence interval: 1.29–3.05). Subgroup analysis showed no significant positive associations across different demographics and comorbidities, including sex, age, hypertension, HbA1c (glycated hemoglobin), and dyslipidemia.ConclusionThis study found a positive relationship between NLR and DN, DR, and DPN. In contrast, SII and PLR were found to be only associated with DN and DR. Therefore, for the diagnosis of diabetic microvascular complications, SII, NLR and PLR are highly valuable.https://www.frontiersin.org/articles/10.3389/fendo.2024.1367376/fullT2DMdiabetic microvascular complicationsSIINLRPLR |
| spellingShingle | Jiahang Li Xueying Wang Wenjing Jia Wenjing Jia Kai Wang Kai Wang Wenju Wang Weibo Diao Feiya Ou Jing Ma Yan Yang Yan Yang Association of the systemic immuno-inflammation index, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio with diabetic microvascular complications Frontiers in Endocrinology T2DM diabetic microvascular complications SII NLR PLR |
| title | Association of the systemic immuno-inflammation index, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio with diabetic microvascular complications |
| title_full | Association of the systemic immuno-inflammation index, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio with diabetic microvascular complications |
| title_fullStr | Association of the systemic immuno-inflammation index, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio with diabetic microvascular complications |
| title_full_unstemmed | Association of the systemic immuno-inflammation index, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio with diabetic microvascular complications |
| title_short | Association of the systemic immuno-inflammation index, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio with diabetic microvascular complications |
| title_sort | association of the systemic immuno inflammation index neutrophil to lymphocyte ratio and platelet to lymphocyte ratio with diabetic microvascular complications |
| topic | T2DM diabetic microvascular complications SII NLR PLR |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1367376/full |
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