Annexin A2 in Fibrinolysis, Inflammation and Fibrosis
As a cell surface tissue plasminogen activator (tPA)-plasminogen receptor, the annexin A2 (A2) complex facilitates plasmin generation on the endothelial cell surface, and is an established regulator of hemostasis. Whereas A2 is overexpressed in hemorrhagic disease such as acute promyelocytic leukemi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/13/6836 |
| _version_ | 1797528730487226368 |
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| author | Hana I. Lim Katherine A. Hajjar |
| author_facet | Hana I. Lim Katherine A. Hajjar |
| author_sort | Hana I. Lim |
| collection | DOAJ |
| description | As a cell surface tissue plasminogen activator (tPA)-plasminogen receptor, the annexin A2 (A2) complex facilitates plasmin generation on the endothelial cell surface, and is an established regulator of hemostasis. Whereas A2 is overexpressed in hemorrhagic disease such as acute promyelocytic leukemia, its underexpression or impairment may result in thrombosis, as in antiphospholipid syndrome, venous thromboembolism, or atherosclerosis. Within immune response cells, A2 orchestrates membrane repair, vesicle fusion, and cytoskeletal organization, thus playing a critical role in inflammatory response and tissue injury. Dysregulation of A2 is evident in multiple human disorders, and may contribute to the pathogenesis of various inflammatory disorders. The fibrinolytic system, moreover, is central to wound healing through its ability to remodel the provisional matrix and promote angiogenesis. A2 dysfunction may also promote tissue fibrogenesis and end-organ fibrosis. |
| first_indexed | 2024-03-10T10:03:32Z |
| format | Article |
| id | doaj.art-627739c8aa854a418fa2c64fc31c9c77 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:03:32Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-627739c8aa854a418fa2c64fc31c9c772023-11-22T01:43:44ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012213683610.3390/ijms22136836Annexin A2 in Fibrinolysis, Inflammation and FibrosisHana I. Lim0Katherine A. Hajjar1Division of Hematology and Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USADivision of Hematology and Oncology, Department of Pediatrics, Weill Cornell Medicine, New York, NY 10065, USAAs a cell surface tissue plasminogen activator (tPA)-plasminogen receptor, the annexin A2 (A2) complex facilitates plasmin generation on the endothelial cell surface, and is an established regulator of hemostasis. Whereas A2 is overexpressed in hemorrhagic disease such as acute promyelocytic leukemia, its underexpression or impairment may result in thrombosis, as in antiphospholipid syndrome, venous thromboembolism, or atherosclerosis. Within immune response cells, A2 orchestrates membrane repair, vesicle fusion, and cytoskeletal organization, thus playing a critical role in inflammatory response and tissue injury. Dysregulation of A2 is evident in multiple human disorders, and may contribute to the pathogenesis of various inflammatory disorders. The fibrinolytic system, moreover, is central to wound healing through its ability to remodel the provisional matrix and promote angiogenesis. A2 dysfunction may also promote tissue fibrogenesis and end-organ fibrosis.https://www.mdpi.com/1422-0067/22/13/6836annexin A2fibrinolysisinflammationfibrosisthrombosisautoimmune disease |
| spellingShingle | Hana I. Lim Katherine A. Hajjar Annexin A2 in Fibrinolysis, Inflammation and Fibrosis International Journal of Molecular Sciences annexin A2 fibrinolysis inflammation fibrosis thrombosis autoimmune disease |
| title | Annexin A2 in Fibrinolysis, Inflammation and Fibrosis |
| title_full | Annexin A2 in Fibrinolysis, Inflammation and Fibrosis |
| title_fullStr | Annexin A2 in Fibrinolysis, Inflammation and Fibrosis |
| title_full_unstemmed | Annexin A2 in Fibrinolysis, Inflammation and Fibrosis |
| title_short | Annexin A2 in Fibrinolysis, Inflammation and Fibrosis |
| title_sort | annexin a2 in fibrinolysis inflammation and fibrosis |
| topic | annexin A2 fibrinolysis inflammation fibrosis thrombosis autoimmune disease |
| url | https://www.mdpi.com/1422-0067/22/13/6836 |
| work_keys_str_mv | AT hanailim annexina2infibrinolysisinflammationandfibrosis AT katherineahajjar annexina2infibrinolysisinflammationandfibrosis |