Functional Interplay between Small Non-Coding RNAs and RNA Modification in the Brain
Small non-coding RNAs are essential for transcription, translation and gene regulation in all cell types, but are particularly important in neurons, with known roles in neurodevelopment, neuroplasticity and neurological disease. Many small non-coding RNAs are directly involved in the post-transcript...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-06-01
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| Series: | Non-Coding RNA |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2311-553X/4/2/15 |
| _version_ | 1831694401887272960 |
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| author | Laura J. Leighton Timothy W. Bredy |
| author_facet | Laura J. Leighton Timothy W. Bredy |
| author_sort | Laura J. Leighton |
| collection | DOAJ |
| description | Small non-coding RNAs are essential for transcription, translation and gene regulation in all cell types, but are particularly important in neurons, with known roles in neurodevelopment, neuroplasticity and neurological disease. Many small non-coding RNAs are directly involved in the post-transcriptional modification of other RNA species, while others are themselves substrates for modification, or are functionally modulated by modification of their target RNAs. In this review, we explore the known and potential functions of several distinct classes of small non-coding RNAs in the mammalian brain, focusing on the newly recognised interplay between the epitranscriptome and the activity of small RNAs. We discuss the potential for this relationship to influence the spatial and temporal dynamics of gene activation in the brain, and predict that further research in the field of epitranscriptomics will identify interactions between small RNAs and RNA modifications which are essential for higher order brain functions such as learning and memory. |
| first_indexed | 2024-12-20T12:33:38Z |
| format | Article |
| id | doaj.art-6277c6300092476092a75ad3c40563e6 |
| institution | Directory Open Access Journal |
| issn | 2311-553X |
| language | English |
| last_indexed | 2024-12-20T12:33:38Z |
| publishDate | 2018-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Non-Coding RNA |
| spelling | doaj.art-6277c6300092476092a75ad3c40563e62022-12-21T19:40:39ZengMDPI AGNon-Coding RNA2311-553X2018-06-01421510.3390/ncrna4020015ncrna4020015Functional Interplay between Small Non-Coding RNAs and RNA Modification in the BrainLaura J. Leighton0Timothy W. Bredy1Cognitive Neuroepigenetics Laboratory, Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, AustraliaCognitive Neuroepigenetics Laboratory, Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, AustraliaSmall non-coding RNAs are essential for transcription, translation and gene regulation in all cell types, but are particularly important in neurons, with known roles in neurodevelopment, neuroplasticity and neurological disease. Many small non-coding RNAs are directly involved in the post-transcriptional modification of other RNA species, while others are themselves substrates for modification, or are functionally modulated by modification of their target RNAs. In this review, we explore the known and potential functions of several distinct classes of small non-coding RNAs in the mammalian brain, focusing on the newly recognised interplay between the epitranscriptome and the activity of small RNAs. We discuss the potential for this relationship to influence the spatial and temporal dynamics of gene activation in the brain, and predict that further research in the field of epitranscriptomics will identify interactions between small RNAs and RNA modifications which are essential for higher order brain functions such as learning and memory.http://www.mdpi.com/2311-553X/4/2/15epitranscriptomicsneurobiologynon-coding RNAsmall RNA |
| spellingShingle | Laura J. Leighton Timothy W. Bredy Functional Interplay between Small Non-Coding RNAs and RNA Modification in the Brain Non-Coding RNA epitranscriptomics neurobiology non-coding RNA small RNA |
| title | Functional Interplay between Small Non-Coding RNAs and RNA Modification in the Brain |
| title_full | Functional Interplay between Small Non-Coding RNAs and RNA Modification in the Brain |
| title_fullStr | Functional Interplay between Small Non-Coding RNAs and RNA Modification in the Brain |
| title_full_unstemmed | Functional Interplay between Small Non-Coding RNAs and RNA Modification in the Brain |
| title_short | Functional Interplay between Small Non-Coding RNAs and RNA Modification in the Brain |
| title_sort | functional interplay between small non coding rnas and rna modification in the brain |
| topic | epitranscriptomics neurobiology non-coding RNA small RNA |
| url | http://www.mdpi.com/2311-553X/4/2/15 |
| work_keys_str_mv | AT laurajleighton functionalinterplaybetweensmallnoncodingrnasandrnamodificationinthebrain AT timothywbredy functionalinterplaybetweensmallnoncodingrnasandrnamodificationinthebrain |