Effects of diazoxide on rat isolated atria
Background: It is generally accepted that the selective adenosine triphosphate-dependent potassium channel openers (KATP openers) have a dramatic role in the treatment of some cardiovascular disorders. The aim of this study was to investigate the effects of diazoxide, a potent ATP-related potassium...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | fas |
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Tehran University of Medical Sciences
2012-11-01
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| Series: | Tehran University Medical Journal |
| Subjects: | |
| Online Access: | http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-82&slc_lang=en&sid=1 |
| _version_ | 1819204485779554304 |
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| author | Nikoui V Pazoki Toroudi H Ostadhadi S Rahmani A Bakhtiarian A |
| author_facet | Nikoui V Pazoki Toroudi H Ostadhadi S Rahmani A Bakhtiarian A |
| author_sort | Nikoui V |
| collection | DOAJ |
| description | Background: It is generally accepted that the selective adenosine triphosphate-dependent potassium channel openers (KATP openers) have a dramatic role in the treatment of some cardiovascular disorders. The aim of this study was to investigate the effects of diazoxide, a potent ATP-related potassium channel opener, on spontaneously beating isolated rat atria to achieve more accurate approaches to treat cardiovascular diseases, such as atrial related disorders including atrial arrhythmias.Methods: After induction of anesthesia, we exsected the heart and isolated the atria of 48 male Wistar rats. Later, we recorded the beating and contractile force of the atria by a physiograph. Subsequently, we studied the effects of diazoxide (2 to 100 µg/mL) on beating and contractile force of the isolated atria 5, 10, 15 and 20 minutes after applying the drug onto the atria.Results: Diazoxide administration (2 to 100 µg/mL) showed a significant decrease (7% to 49% depending on concentration) in atrial beatings (P≤0.001) and in contractile force (1.5% to 67% depending on concentration), (P≤0.001). The effects began several minutes after applying the drug onto the tissues.Conclusion: This study revealed that diazoxide has a direct concentration-dependent effect on cardiac performance and leads to reduction in beating rates and contractile force of the heart. This effect seems to be related to the activation of mitochondrial or sarcolemmal KATP channels. Since the inhibitory action of diazoxide on the heart was very remarkable and prompt, this agent may also exhibit antiarrhythmic properties. |
| first_indexed | 2024-12-23T04:36:34Z |
| format | Article |
| id | doaj.art-62790754fef14ed6b10bbdf2cd7fb5ee |
| institution | Directory Open Access Journal |
| issn | 1683-1764 1735-7322 |
| language | fas |
| last_indexed | 2024-12-23T04:36:34Z |
| publishDate | 2012-11-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Tehran University Medical Journal |
| spelling | doaj.art-62790754fef14ed6b10bbdf2cd7fb5ee2022-12-21T17:59:53ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222012-11-01708467472Effects of diazoxide on rat isolated atriaNikoui V0Pazoki Toroudi H1Ostadhadi S2Rahmani A3Bakhtiarian A4 Background: It is generally accepted that the selective adenosine triphosphate-dependent potassium channel openers (KATP openers) have a dramatic role in the treatment of some cardiovascular disorders. The aim of this study was to investigate the effects of diazoxide, a potent ATP-related potassium channel opener, on spontaneously beating isolated rat atria to achieve more accurate approaches to treat cardiovascular diseases, such as atrial related disorders including atrial arrhythmias.Methods: After induction of anesthesia, we exsected the heart and isolated the atria of 48 male Wistar rats. Later, we recorded the beating and contractile force of the atria by a physiograph. Subsequently, we studied the effects of diazoxide (2 to 100 µg/mL) on beating and contractile force of the isolated atria 5, 10, 15 and 20 minutes after applying the drug onto the atria.Results: Diazoxide administration (2 to 100 µg/mL) showed a significant decrease (7% to 49% depending on concentration) in atrial beatings (P≤0.001) and in contractile force (1.5% to 67% depending on concentration), (P≤0.001). The effects began several minutes after applying the drug onto the tissues.Conclusion: This study revealed that diazoxide has a direct concentration-dependent effect on cardiac performance and leads to reduction in beating rates and contractile force of the heart. This effect seems to be related to the activation of mitochondrial or sarcolemmal KATP channels. Since the inhibitory action of diazoxide on the heart was very remarkable and prompt, this agent may also exhibit antiarrhythmic properties.http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-82&slc_lang=en&sid=1atriabeating heartcardiac arrhythmiadiazoxideisolatedpotassium channel |
| spellingShingle | Nikoui V Pazoki Toroudi H Ostadhadi S Rahmani A Bakhtiarian A Effects of diazoxide on rat isolated atria Tehran University Medical Journal atria beating heart cardiac arrhythmia diazoxide isolated potassium channel |
| title | Effects of diazoxide on rat isolated atria |
| title_full | Effects of diazoxide on rat isolated atria |
| title_fullStr | Effects of diazoxide on rat isolated atria |
| title_full_unstemmed | Effects of diazoxide on rat isolated atria |
| title_short | Effects of diazoxide on rat isolated atria |
| title_sort | effects of diazoxide on rat isolated atria |
| topic | atria beating heart cardiac arrhythmia diazoxide isolated potassium channel |
| url | http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-82&slc_lang=en&sid=1 |
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