Extracellular vesicles in the tumor microenvironment: old stories, but new tales
Abstract Mammalian cells synthesize and release heterogeneous extracellular vesicles (EVs) which can be generally recognized as subclasses including exosomes, microvesicles (MVs), and apoptotic bodies (ABs), each differing in their biogenesis, composition and biological functions from others. EVs ca...
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| Format: | Article |
| Language: | English |
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BMC
2019-03-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12943-019-0980-8 |
| _version_ | 1819049274622607360 |
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| author | Liu Han Eric W.-F. Lam Yu Sun |
| author_facet | Liu Han Eric W.-F. Lam Yu Sun |
| author_sort | Liu Han |
| collection | DOAJ |
| description | Abstract Mammalian cells synthesize and release heterogeneous extracellular vesicles (EVs) which can be generally recognized as subclasses including exosomes, microvesicles (MVs), and apoptotic bodies (ABs), each differing in their biogenesis, composition and biological functions from others. EVs can originate from normal or cancer cells, transfer bioactive cargoes to both adjacent and distant sites, and orchestrate multiple key pathophysiological events such as carcinogenesis and malignant progression. Emerging as key messengers that mediate intercellular communications, EVs are being paid substantial attention in various disciplines including but not limited to cancer biology and immunology. Increasing lines of research advances have revealed the critical role of EVs in the establishment and maintenance of the tumor microenvironment (TME), including sustaining cell proliferation, evading growth suppression, resisting cell death, acquiring genomic instability and reprogramming stromal cell lineages, together contributing to the generation of a functionally remodeled TME. In this article, we present updates on major topics that document how EVs are implicated in proliferative expansion of cancer cells, promotion of drug resistance, reprogramming of metabolic activity, enhancement of metastatic potential, induction of angiogenesis, and escape from immune surveillance. Appropriate and insightful understanding of EVs and their contribution to cancer progression can lead to new avenues in the prevention, diagnosis and treatment of human malignancies in future medicine. |
| first_indexed | 2024-12-21T11:29:33Z |
| format | Article |
| id | doaj.art-627dbc12ed57421dbe7b94dd4592dde1 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-12-21T11:29:33Z |
| publishDate | 2019-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-627dbc12ed57421dbe7b94dd4592dde12022-12-21T19:05:35ZengBMCMolecular Cancer1476-45982019-03-0118111410.1186/s12943-019-0980-8Extracellular vesicles in the tumor microenvironment: old stories, but new talesLiu Han0Eric W.-F. Lam1Yu Sun2CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of SciencesDepartment of Surgery and Cancer, Imperial College LondonCAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of SciencesAbstract Mammalian cells synthesize and release heterogeneous extracellular vesicles (EVs) which can be generally recognized as subclasses including exosomes, microvesicles (MVs), and apoptotic bodies (ABs), each differing in their biogenesis, composition and biological functions from others. EVs can originate from normal or cancer cells, transfer bioactive cargoes to both adjacent and distant sites, and orchestrate multiple key pathophysiological events such as carcinogenesis and malignant progression. Emerging as key messengers that mediate intercellular communications, EVs are being paid substantial attention in various disciplines including but not limited to cancer biology and immunology. Increasing lines of research advances have revealed the critical role of EVs in the establishment and maintenance of the tumor microenvironment (TME), including sustaining cell proliferation, evading growth suppression, resisting cell death, acquiring genomic instability and reprogramming stromal cell lineages, together contributing to the generation of a functionally remodeled TME. In this article, we present updates on major topics that document how EVs are implicated in proliferative expansion of cancer cells, promotion of drug resistance, reprogramming of metabolic activity, enhancement of metastatic potential, induction of angiogenesis, and escape from immune surveillance. Appropriate and insightful understanding of EVs and their contribution to cancer progression can lead to new avenues in the prevention, diagnosis and treatment of human malignancies in future medicine.http://link.springer.com/article/10.1186/s12943-019-0980-8Extracellular vesiclesTumor microenvironmentCancer biologyTherapeutic targetClinical biomarker |
| spellingShingle | Liu Han Eric W.-F. Lam Yu Sun Extracellular vesicles in the tumor microenvironment: old stories, but new tales Molecular Cancer Extracellular vesicles Tumor microenvironment Cancer biology Therapeutic target Clinical biomarker |
| title | Extracellular vesicles in the tumor microenvironment: old stories, but new tales |
| title_full | Extracellular vesicles in the tumor microenvironment: old stories, but new tales |
| title_fullStr | Extracellular vesicles in the tumor microenvironment: old stories, but new tales |
| title_full_unstemmed | Extracellular vesicles in the tumor microenvironment: old stories, but new tales |
| title_short | Extracellular vesicles in the tumor microenvironment: old stories, but new tales |
| title_sort | extracellular vesicles in the tumor microenvironment old stories but new tales |
| topic | Extracellular vesicles Tumor microenvironment Cancer biology Therapeutic target Clinical biomarker |
| url | http://link.springer.com/article/10.1186/s12943-019-0980-8 |
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