The role of antifreeze glycoprotein (AFGP) and polyvinyl alcohol/polyglycerol (X/Z-1000) as ice modulators during partial freezing of rat livers

The role of antifreeze glycoprotein (AFGP) and polyvinyl alcohol/polyglycerol (X/Z-1000) as ice modulators during partial freezing of rat livers

Introduction: The current liver organ shortage has pushed the field of transplantation to develop new methods to prolong the preservation time of livers from the current clinical standard of static cold storage. Our approach, termed partial freezing, aims to induce a thermodynamically stable frozen...

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Bibliographic Details
Main Authors: Shannon N. Tessier, Omar Haque, Casie A. Pendexter, Stephanie E. J. Cronin, Ehab O. A. Hafiz, Lindong Weng, Heidi Yeh, James F. Markmann, Michael J. Taylor, Gregory M. Fahy, Mehmet Toner, Korkut Uygun
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Physics
Subjects:
antifreeze glycoprotein
polyvinyl alcohol
polyglycerol
cryopreservation
partial freezing
machine perfusion
Online Access:https://www.frontiersin.org/articles/10.3389/fphy.2022.1033613/full

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