Analysis of Risk Factors Associated with Candidemia Among Patients with or without COVID-19 in Intensive Care Units During the Pandemic Process: A Multicenter Study
Introduction: The objective of this study was to compare the risk factors and mortality rates of candidemia among patients with and without COVID-19 in the intensive care units (ICU). Materials and Methods: This study is a retrospective multicenter observational study, in ICUs of 12 hospitals (eig...
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| Format: | Article |
| Language: | English |
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Bilimsel Tip Yayinevi
2023-09-01
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| Series: | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| Subjects: | |
| Online Access: | http://www.floradergisi.org/managete/fu_folder/2023-03/2023-28-03-456-465.pdf |
| _version_ | 1797676881414193152 |
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| author | Taliha Karakök Melih Gaffar Gözükara Yeşim Uygun Kızmaz Yakup Demir Melike Törüyenler Coşkunpınar Şerife Altun Demircan Yusuf Arslan Pelin İlkören Eda Alp Göker Ahmet Doğan Türkan Tüzün Şükran Sevim Yasemin Çakır Mehmet Emirhan Işık Çiğdem Mermutluoğlu Alpay Azap Sami Kınıklı Süda Tekin Serap Şimşek Yavuz Sedef Zeliha Öner |
| author_facet | Taliha Karakök Melih Gaffar Gözükara Yeşim Uygun Kızmaz Yakup Demir Melike Törüyenler Coşkunpınar Şerife Altun Demircan Yusuf Arslan Pelin İlkören Eda Alp Göker Ahmet Doğan Türkan Tüzün Şükran Sevim Yasemin Çakır Mehmet Emirhan Işık Çiğdem Mermutluoğlu Alpay Azap Sami Kınıklı Süda Tekin Serap Şimşek Yavuz Sedef Zeliha Öner |
| author_sort | Taliha Karakök |
| collection | DOAJ |
| description | Introduction: The objective of this study was to compare the risk factors and mortality rates of candidemia among patients with and without COVID-19 in the intensive care units (ICU).
Materials and Methods: This study is a retrospective multicenter observational study, in ICUs of 12 hospitals (eight tertiary and four secondary hospitals) in Türkiye. All adult patients (>18 years) hospitalized in ICUs and developed candidemia between 01.01.2020- 31.12.2021 were included. The following data were collected: age, gender, nasopharyngeal swab SARS-CoV-2 PCR test, species of Candida (Candida albicans or non-albicans Candida), comorbidities, ICU stay, antibiotic use, corticosteroid, and anti-cytokine therapy, central venous catheter (CVC), abdominal surgery, parenteral nutrition, mechanical ventilation (MV), other cultures isolated Candida spp., echocardiography (ECO), mortality. Data from patients with or without COVID-19 were compared.
Results: A total of 188 patients, 66 COVID-19 and 122 non-COVID-19, were included in the study. The median age of the patients was 69.5 and there were no differences between the groups. 185 (98.4%) patients had a history of antibiotic use. Sixteen patients, all from the COVID-19 group, had a history of anti-cytokine therapy. Corticosteroid use was higher in COVID-19 patients (p< 0.001). Intraabdominal surgery was higher in the non-COVID-19 group (p< 0.014). C. albicans was isolated from 36.7% of total patients and the remaining were non-albicans Candida species. The overall mortality was higher in COVID-19 patients (p= 0.014). Alzheimer’s and malignancies were higher in non-COVID-19 patients. Intraabdominal surgery, MV, and CVC were higher in tertiary care hospitals whereas parenteral nutrition was higher in secondary care hospitals.
Conclusion: Immunosuppressive treatments administered to COVID-19 patients pose a risk in terms of candidemia. Risk factors may differ between secondary and tertiary care hospitals. Preventable risk factors should be determined on a hospital basis and appropriate infection control measures should be taken. |
| first_indexed | 2024-03-11T22:36:50Z |
| format | Article |
| id | doaj.art-6281f59066984eacb5f9be9dfc48f33f |
| institution | Directory Open Access Journal |
| issn | 1300-932X |
| language | English |
| last_indexed | 2024-03-11T22:36:50Z |
| publishDate | 2023-09-01 |
| publisher | Bilimsel Tip Yayinevi |
| record_format | Article |
| series | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| spelling | doaj.art-6281f59066984eacb5f9be9dfc48f33f2023-09-22T12:47:44ZengBilimsel Tip YayineviFlora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi1300-932X2023-09-0128345646510.5578/flora.20239716Analysis of Risk Factors Associated with Candidemia Among Patients with or without COVID-19 in Intensive Care Units During the Pandemic Process: A Multicenter StudyTaliha Karakök0https://orcid.org/0000-0003-4369-229XMelih Gaffar Gözükara1https://orcid.org/0000-0002-6147-4053Yeşim Uygun Kızmaz2https://orcid.org/0000-0002-8208-8485Yakup Demir3https://orcid.org/0000-0003-2419-3436Melike Törüyenler Coşkunpınar4https://orcid.org/0000-0003-2152-5626Şerife Altun Demircan5https://orcid.org/0000-0002-9295-4578Yusuf Arslan6https://orcid.org/0000-0002-1479-6009Pelin İlkören7https://orcid.org/0000-0002-4006-3562Eda Alp Göker8https://orcid.org/0000-0002-9026-4741Ahmet Doğan9https://orcid.org/0000-0001-5110-4027Türkan Tüzün10https://orcid.org/0000-0003-0603-8731Şükran Sevim11https://orcid.org/0000-0001-6707-1303Yasemin Çakır12https://orcid.org/0000-0001-5510-3216Mehmet Emirhan Işık13https://orcid.org/0000-0002-0699-8890Çiğdem Mermutluoğlu14https://orcid.org/0000-0003-1836-6281Alpay Azap15https://orcid.org/0000-0001-5035-055XSami Kınıklı16https://orcid.org/0000-0001-9841-9456Süda Tekin17https://orcid.org/0000-0001-9419-8713Serap Şimşek Yavuz18https://orcid.org/0000-0002-4675-169XSedef Zeliha Öner19https://orcid.org/0000-0002-9964-2526Clinic of Infectious Diseases and Clinical Microbiology, Fatsa State Hospital, Ordu, TürkiyePublic Health, Sincan District Health Directorate, Ankara, TürkiyeClinic of Infectious Diseases and Clinical Microbiology, Kartal Koşuyolu High Specialization Training and Research Hospital, İstanbul, TürkiyeDepartment of Infectipous Diseases and Clinical Microbiology, Dicle University Faculty of Medicine, Diyarbakır, TürkiyeDepartment of Infectious Diseases and Clinical Microbiology, Ankara University Faculty of Medicine, Ankara, TürkiyeClinic of Infectious Diseases and Clinical Microbiology, Ankara Training and Research Hospital, Ankara, TürkiyeClinic of Infectious Diseases and Clinical Microbiology, Batman Training and Research Hospital, Batman, TürkiyeDepartment of Infectious Diseases and Clinical Microbiology, Koç University Faculty of Medicine, İstanbul, TürkiyeDepartment of Infectious Diseases and Clinical Microbiology, İstanbul University Faculty of Medicine, İstanbul, TürkiyeClinic of Infectious Diseases and Clinical Microbiology, Ordu State Hospital, Ordu, TürkiyeDepartment of Infectious Diseases and Clinical Microbiology, Pamukkale University Faculty of Medicine, Denizli, TürkiyeClinic of Infectious Diseases and Clinical Microbiology, Mardin Kızıltepe State Hospital, Mardin, TürkiyeClinic of Infectious Diseases and Clinical Microbiology, Ağrı Doğubayazıt Dr. Yaşar Eryılmaz State Hospital, Ağrı, TürkiyeClinic of Infectious Diseases and Clinical Microbiology, Kartal Koşuyolu High Specialization Training and Research Hospital, İstanbul, TürkiyeDepartment of Infectipous Diseases and Clinical Microbiology, Dicle University Faculty of Medicine, Diyarbakır, TürkiyeDepartment of Infectious Diseases and Clinical Microbiology, Ankara University Faculty of Medicine, Ankara, TürkiyeClinic of Infectious Diseases and Clinical Microbiology, Ankara Training and Research Hospital, Ankara, TürkiyeDepartment of Infectious Diseases and Clinical Microbiology, Koç University Faculty of Medicine, İstanbul, TürkiyeDepartment of Infectious Diseases and Clinical Microbiology, İstanbul University Faculty of Medicine, İstanbul, TürkiyeDepartment of Microbiology, Pamukkale University Faculty of Medicine, Denizli, TürkiyeIntroduction: The objective of this study was to compare the risk factors and mortality rates of candidemia among patients with and without COVID-19 in the intensive care units (ICU). Materials and Methods: This study is a retrospective multicenter observational study, in ICUs of 12 hospitals (eight tertiary and four secondary hospitals) in Türkiye. All adult patients (>18 years) hospitalized in ICUs and developed candidemia between 01.01.2020- 31.12.2021 were included. The following data were collected: age, gender, nasopharyngeal swab SARS-CoV-2 PCR test, species of Candida (Candida albicans or non-albicans Candida), comorbidities, ICU stay, antibiotic use, corticosteroid, and anti-cytokine therapy, central venous catheter (CVC), abdominal surgery, parenteral nutrition, mechanical ventilation (MV), other cultures isolated Candida spp., echocardiography (ECO), mortality. Data from patients with or without COVID-19 were compared. Results: A total of 188 patients, 66 COVID-19 and 122 non-COVID-19, were included in the study. The median age of the patients was 69.5 and there were no differences between the groups. 185 (98.4%) patients had a history of antibiotic use. Sixteen patients, all from the COVID-19 group, had a history of anti-cytokine therapy. Corticosteroid use was higher in COVID-19 patients (p< 0.001). Intraabdominal surgery was higher in the non-COVID-19 group (p< 0.014). C. albicans was isolated from 36.7% of total patients and the remaining were non-albicans Candida species. The overall mortality was higher in COVID-19 patients (p= 0.014). Alzheimer’s and malignancies were higher in non-COVID-19 patients. Intraabdominal surgery, MV, and CVC were higher in tertiary care hospitals whereas parenteral nutrition was higher in secondary care hospitals. Conclusion: Immunosuppressive treatments administered to COVID-19 patients pose a risk in terms of candidemia. Risk factors may differ between secondary and tertiary care hospitals. Preventable risk factors should be determined on a hospital basis and appropriate infection control measures should be taken. http://www.floradergisi.org/managete/fu_folder/2023-03/2023-28-03-456-465.pdfcandidemiacovid-19risk factorsintensive care unit |
| spellingShingle | Taliha Karakök Melih Gaffar Gözükara Yeşim Uygun Kızmaz Yakup Demir Melike Törüyenler Coşkunpınar Şerife Altun Demircan Yusuf Arslan Pelin İlkören Eda Alp Göker Ahmet Doğan Türkan Tüzün Şükran Sevim Yasemin Çakır Mehmet Emirhan Işık Çiğdem Mermutluoğlu Alpay Azap Sami Kınıklı Süda Tekin Serap Şimşek Yavuz Sedef Zeliha Öner Analysis of Risk Factors Associated with Candidemia Among Patients with or without COVID-19 in Intensive Care Units During the Pandemic Process: A Multicenter Study Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi candidemia covid-19 risk factors intensive care unit |
| title | Analysis of Risk Factors Associated with Candidemia Among Patients with or without COVID-19 in Intensive Care Units During the Pandemic Process: A Multicenter Study |
| title_full | Analysis of Risk Factors Associated with Candidemia Among Patients with or without COVID-19 in Intensive Care Units During the Pandemic Process: A Multicenter Study |
| title_fullStr | Analysis of Risk Factors Associated with Candidemia Among Patients with or without COVID-19 in Intensive Care Units During the Pandemic Process: A Multicenter Study |
| title_full_unstemmed | Analysis of Risk Factors Associated with Candidemia Among Patients with or without COVID-19 in Intensive Care Units During the Pandemic Process: A Multicenter Study |
| title_short | Analysis of Risk Factors Associated with Candidemia Among Patients with or without COVID-19 in Intensive Care Units During the Pandemic Process: A Multicenter Study |
| title_sort | analysis of risk factors associated with candidemia among patients with or without covid 19 in intensive care units during the pandemic process a multicenter study |
| topic | candidemia covid-19 risk factors intensive care unit |
| url | http://www.floradergisi.org/managete/fu_folder/2023-03/2023-28-03-456-465.pdf |
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