New oxadiazole and pyrazoline derivatives as anti-proliferative agents targeting EGFR-TK: design, synthesis, biological evaluation and molecular docking study

New oxadiazole and pyrazoline derivatives as anti-proliferative agents targeting EGFR-TK: design, synthesis, biological evaluation and molecular docking study

Abstract Two new series of oxadiazole and pyrazoline derivatives were designed and synthesized as promising EGFR-TK inhibitors. The in vitro antiproliferative activity was studied against three human cancer cell lines; HCT116, HepG-2 and MCF7 using MTT assay. Compound 10c showed the most potent anti...

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Bibliographic Details
Main Authors: Marwa I. Serag, Samar S. Tawfik, Sahar M. I. Badr, Hassan M. Eisa
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Subjects:
Oxadiazole
Pyrazoline
Anticancer activity
EGFR kinase
Docking studies
Online Access:https://doi.org/10.1038/s41598-024-55046-0

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