The TROVE module: A common element in Telomerase, Ro and Vault ribonucleoproteins
<p>Abstract</p> <p>Background</p> <p>Ribonucleoproteins carry out a variety of important tasks in the cell. In this study we show that a number of these contain a novel module, that we speculate mediates RNA-binding.</p> <p>Results</p> <p>The TRO...
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2003-10-01
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| Series: | BMC Bioinformatics |
| Subjects: | |
| Online Access: | http://www.biomedcentral.com/1471-2105/4/49 |
| _version_ | 1818755419436220416 |
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| author | Bateman Alex Kickhoefer Valerie |
| author_facet | Bateman Alex Kickhoefer Valerie |
| author_sort | Bateman Alex |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Ribonucleoproteins carry out a variety of important tasks in the cell. In this study we show that a number of these contain a novel module, that we speculate mediates RNA-binding.</p> <p>Results</p> <p>The TROVE module – Telomerase, Ro and Vault module – is found in TEP1 and Ro60 the protein components of three ribonucleoprotein particles. This novel module, consisting of one or more domains, may be involved in binding the RNA components of the three RNPs, which are telomerase RNA, Y RNA and vault RNA. A second conserved region in these proteins is shown to be a member of the vWA domain family. The vWA domain in TEP1 is closely related to the previously recognised vWA domain in VPARP a second component of the vault particle. This vWA domain may mediate interactions between these vault components or bind as yet unidentified components of the RNPs.</p> <p>Conclusions</p> <p>This work suggests that a number of ribonucleoprotein components use a common RNA-binding module. The TROVE module is also found in bacterial ribonucleoproteins suggesting an ancient origin for these ribonucleoproteins.</p> |
| first_indexed | 2024-12-18T05:38:51Z |
| format | Article |
| id | doaj.art-62861ef1d659422ea8994907a4473792 |
| institution | Directory Open Access Journal |
| issn | 1471-2105 |
| language | English |
| last_indexed | 2024-12-18T05:38:51Z |
| publishDate | 2003-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Bioinformatics |
| spelling | doaj.art-62861ef1d659422ea8994907a44737922022-12-21T21:19:14ZengBMCBMC Bioinformatics1471-21052003-10-01414910.1186/1471-2105-4-49The TROVE module: A common element in Telomerase, Ro and Vault ribonucleoproteinsBateman AlexKickhoefer Valerie<p>Abstract</p> <p>Background</p> <p>Ribonucleoproteins carry out a variety of important tasks in the cell. In this study we show that a number of these contain a novel module, that we speculate mediates RNA-binding.</p> <p>Results</p> <p>The TROVE module – Telomerase, Ro and Vault module – is found in TEP1 and Ro60 the protein components of three ribonucleoprotein particles. This novel module, consisting of one or more domains, may be involved in binding the RNA components of the three RNPs, which are telomerase RNA, Y RNA and vault RNA. A second conserved region in these proteins is shown to be a member of the vWA domain family. The vWA domain in TEP1 is closely related to the previously recognised vWA domain in VPARP a second component of the vault particle. This vWA domain may mediate interactions between these vault components or bind as yet unidentified components of the RNPs.</p> <p>Conclusions</p> <p>This work suggests that a number of ribonucleoprotein components use a common RNA-binding module. The TROVE module is also found in bacterial ribonucleoproteins suggesting an ancient origin for these ribonucleoproteins.</p>http://www.biomedcentral.com/1471-2105/4/49Y RNAvRNAtelomerase RNAVPARPTEP1Ro60 |
| spellingShingle | Bateman Alex Kickhoefer Valerie The TROVE module: A common element in Telomerase, Ro and Vault ribonucleoproteins BMC Bioinformatics Y RNA vRNA telomerase RNA VPARP TEP1 Ro60 |
| title | The TROVE module: A common element in Telomerase, Ro and Vault ribonucleoproteins |
| title_full | The TROVE module: A common element in Telomerase, Ro and Vault ribonucleoproteins |
| title_fullStr | The TROVE module: A common element in Telomerase, Ro and Vault ribonucleoproteins |
| title_full_unstemmed | The TROVE module: A common element in Telomerase, Ro and Vault ribonucleoproteins |
| title_short | The TROVE module: A common element in Telomerase, Ro and Vault ribonucleoproteins |
| title_sort | trove module a common element in telomerase ro and vault ribonucleoproteins |
| topic | Y RNA vRNA telomerase RNA VPARP TEP1 Ro60 |
| url | http://www.biomedcentral.com/1471-2105/4/49 |
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