Polio Vaccines: Present and Future
The history of polio vaccines and their use illustrates the concept of evolution of vaccines driven by changing epidemiological and socioeconomic conditions. The development of two vaccines against poliomyelitis – inactivated Salk vaccine (IPV) and live oral Sabin vaccine (OPV) – is among the most c...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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Numikom LLC
2018-06-01
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| Series: | Эпидемиология и вакцинопрофилактика |
| Subjects: | |
| Online Access: | https://www.epidemvac.ru/jour/article/view/514 |
| _version_ | 1797879589504024576 |
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| author | K. Chumakov A. A. Ishmukhametov |
| author_facet | K. Chumakov A. A. Ishmukhametov |
| author_sort | K. Chumakov |
| collection | DOAJ |
| description | The history of polio vaccines and their use illustrates the concept of evolution of vaccines driven by changing epidemiological and socioeconomic conditions. The development of two vaccines against poliomyelitis – inactivated Salk vaccine (IPV) and live oral Sabin vaccine (OPV) – is among the most consequential achievements of prophylactic medicine of the past century. Each with their own strengths and weaknesses, they were used over the past 50 years in different settings and different regimens and combinations. This resulted in virtual elimination of the disease in almost the entire world with the exception of a few countries. Continuation of the eradication campaign coordinated by WHO may soon result in complete cessation of wild poliovirus transmission, and poliovirus may join smallpox virus in the club of extinct pathogens. However, unlike smallpox vaccination that was stopped after the interruption of virus circulation, vaccination against poliomyelitis will have to continue into the foreseeable future, due to significant differences in the nature and epidemiology of the viruses. This review provides the reasons for the need to maintain high population immunity against polioviruses, makes the case for developing a new generation of polio vaccines, and discusses their desirable properties as well as new vaccine technologies that could be used to create polio vaccines for the post-eradication environment. |
| first_indexed | 2024-04-10T02:51:01Z |
| format | Article |
| id | doaj.art-62866329732447ed963006f808bb0376 |
| institution | Directory Open Access Journal |
| issn | 2073-3046 2619-0494 |
| language | Russian |
| last_indexed | 2024-04-10T02:51:01Z |
| publishDate | 2018-06-01 |
| publisher | Numikom LLC |
| record_format | Article |
| series | Эпидемиология и вакцинопрофилактика |
| spelling | doaj.art-62866329732447ed963006f808bb03762023-03-13T07:43:15ZrusNumikom LLCЭпидемиология и вакцинопрофилактика2073-30462619-04942018-06-0117341810.31631/2073-3046-2018-17-3-4-18434Polio Vaccines: Present and FutureK. Chumakov0A. A. Ishmukhametov1Центра по оценке и исследованию биологических продуктов, FDA, Silver SpringФГБНУ «Федеральный научный центр исследований и разработки иммунобиологических препаратов им. М. П. Чумакова» РАН, Москва; ФГАОУ ВО Первый Московский государственный медицинский университет им. И. М. Сеченова МЗ РоссииThe history of polio vaccines and their use illustrates the concept of evolution of vaccines driven by changing epidemiological and socioeconomic conditions. The development of two vaccines against poliomyelitis – inactivated Salk vaccine (IPV) and live oral Sabin vaccine (OPV) – is among the most consequential achievements of prophylactic medicine of the past century. Each with their own strengths and weaknesses, they were used over the past 50 years in different settings and different regimens and combinations. This resulted in virtual elimination of the disease in almost the entire world with the exception of a few countries. Continuation of the eradication campaign coordinated by WHO may soon result in complete cessation of wild poliovirus transmission, and poliovirus may join smallpox virus in the club of extinct pathogens. However, unlike smallpox vaccination that was stopped after the interruption of virus circulation, vaccination against poliomyelitis will have to continue into the foreseeable future, due to significant differences in the nature and epidemiology of the viruses. This review provides the reasons for the need to maintain high population immunity against polioviruses, makes the case for developing a new generation of polio vaccines, and discusses their desirable properties as well as new vaccine technologies that could be used to create polio vaccines for the post-eradication environment.https://www.epidemvac.ru/jour/article/view/514вакцинаполиовирусколлективный иммунитет |
| spellingShingle | K. Chumakov A. A. Ishmukhametov Polio Vaccines: Present and Future Эпидемиология и вакцинопрофилактика вакцина полиовирус коллективный иммунитет |
| title | Polio Vaccines: Present and Future |
| title_full | Polio Vaccines: Present and Future |
| title_fullStr | Polio Vaccines: Present and Future |
| title_full_unstemmed | Polio Vaccines: Present and Future |
| title_short | Polio Vaccines: Present and Future |
| title_sort | polio vaccines present and future |
| topic | вакцина полиовирус коллективный иммунитет |
| url | https://www.epidemvac.ru/jour/article/view/514 |
| work_keys_str_mv | AT kchumakov poliovaccinespresentandfuture AT aaishmukhametov poliovaccinespresentandfuture |