Multidrug efflux pumps at the crossroad between antibiotic resistance and bacterial virulence
Multidrug efflux pumps can be involved in bacterial resistance to antibiotics at different levels. Some efflux pumps are constitutively expressed at low levels and contribute to intrinsic resistance. In addition, their overexpression may allow higher levels of resistance. This overexpression can be...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-09-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01483/full |
| _version_ | 1811257260768231424 |
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| author | Manuel Alcalde-Rico Sara Hernando-Amado Paula Blanco Jose L Martinez |
| author_facet | Manuel Alcalde-Rico Sara Hernando-Amado Paula Blanco Jose L Martinez |
| author_sort | Manuel Alcalde-Rico |
| collection | DOAJ |
| description | Multidrug efflux pumps can be involved in bacterial resistance to antibiotics at different levels. Some efflux pumps are constitutively expressed at low levels and contribute to intrinsic resistance. In addition, their overexpression may allow higher levels of resistance. This overexpression can be transient, in the presence of an effector (phenotypic resistance), or constitutive when mutants in the regulatory elements of the expression of efflux pumps are selected (acquired resistance). Efflux pumps are present in all cells, from human to bacteria and are highly conserved, which indicates that they are ancient elements in the evolution of different organisms. Consequently, it has been suggested that, besides antibiotic resistance, bacterial multidrug efflux pumps would likely contribute to other relevant process of the microbial physiology. In the current article, we discuss some specific examples of the role that efflux pumps may have in the bacterial virulence of animals' and plants' pathogens, including the processes of intercellular communication. Based in these evidences, we propose that efflux pumps are at the crossroad between resistance and virulence of bacterial pathogens. Consequently, the comprehensive study of multidrug efflux pumps requires addressing these functions, which are of relevance for the bacterial-host interactions during infection. |
| first_indexed | 2024-04-12T17:53:42Z |
| format | Article |
| id | doaj.art-628671ecceb749e587c55e8d2cbbc3d7 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-12T17:53:42Z |
| publishDate | 2016-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-628671ecceb749e587c55e8d2cbbc3d72022-12-22T03:22:25ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2016-09-01710.3389/fmicb.2016.01483215898Multidrug efflux pumps at the crossroad between antibiotic resistance and bacterial virulenceManuel Alcalde-Rico0Sara Hernando-Amado1Paula Blanco2Jose L Martinez3Centro Nacional de BiotecnologíaCentro Nacional de BiotecnologíaCentro Nacional de BiotecnologíaCentro Nacional de BiotecnologíaMultidrug efflux pumps can be involved in bacterial resistance to antibiotics at different levels. Some efflux pumps are constitutively expressed at low levels and contribute to intrinsic resistance. In addition, their overexpression may allow higher levels of resistance. This overexpression can be transient, in the presence of an effector (phenotypic resistance), or constitutive when mutants in the regulatory elements of the expression of efflux pumps are selected (acquired resistance). Efflux pumps are present in all cells, from human to bacteria and are highly conserved, which indicates that they are ancient elements in the evolution of different organisms. Consequently, it has been suggested that, besides antibiotic resistance, bacterial multidrug efflux pumps would likely contribute to other relevant process of the microbial physiology. In the current article, we discuss some specific examples of the role that efflux pumps may have in the bacterial virulence of animals' and plants' pathogens, including the processes of intercellular communication. Based in these evidences, we propose that efflux pumps are at the crossroad between resistance and virulence of bacterial pathogens. Consequently, the comprehensive study of multidrug efflux pumps requires addressing these functions, which are of relevance for the bacterial-host interactions during infection.http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01483/fullVirulenceAntibiotic resistance mechanismsmultidrug efflux pumpsquorum sensing (QS)Global regulation |
| spellingShingle | Manuel Alcalde-Rico Sara Hernando-Amado Paula Blanco Jose L Martinez Multidrug efflux pumps at the crossroad between antibiotic resistance and bacterial virulence Frontiers in Microbiology Virulence Antibiotic resistance mechanisms multidrug efflux pumps quorum sensing (QS) Global regulation |
| title | Multidrug efflux pumps at the crossroad between antibiotic resistance and bacterial virulence |
| title_full | Multidrug efflux pumps at the crossroad between antibiotic resistance and bacterial virulence |
| title_fullStr | Multidrug efflux pumps at the crossroad between antibiotic resistance and bacterial virulence |
| title_full_unstemmed | Multidrug efflux pumps at the crossroad between antibiotic resistance and bacterial virulence |
| title_short | Multidrug efflux pumps at the crossroad between antibiotic resistance and bacterial virulence |
| title_sort | multidrug efflux pumps at the crossroad between antibiotic resistance and bacterial virulence |
| topic | Virulence Antibiotic resistance mechanisms multidrug efflux pumps quorum sensing (QS) Global regulation |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01483/full |
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