Arctigenin Inhibits Liver Cancer Tumorigenesis by Inhibiting Gankyrin Expression via C/EBPα and PPARα

Arctigenin Inhibits Liver Cancer Tumorigenesis by Inhibiting Gankyrin Expression via C/EBPα and PPARα

Burdock (Arctium lappa) is a popular vegetable in China and Japan that is consumed for its general health benefits. The principal active component of burdock is arctigenin, which shows a range of bioactivities in vivo and in vitro. Here, we investigated the potential anti-tumor effects of arctigenin...

Full description

Bibliographic Details
Main Authors:	Ying Sun, Yu-jun Tan, Zhan-zhao Lu, Bing-bing Li, Cheng-hong Sun, Tao Li, Li-li Zhao, Zhong Liu, Gui-min Zhang, Jing-chun Yao, Jie Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-03-01
Series:	Frontiers in Pharmacology
Subjects:	arctigenin C/EBPα PPARα gankyrin hepatocellular carcinoma
Online Access:	http://journal.frontiersin.org/article/10.3389/fphar.2018.00268/full

Similar Items

Toxicity Study of 28-Day Subcutaneous Injection of Arctigenin in Beagle Dogs
by: Jie Li, et al.
Published: (2019-10-01)

28-Day Oral Chronic Toxicity Study of Arctigenin in Rats
by: Yu-jun Tan, et al.
Published: (2018-09-01)

Elucidation of Arctigenin Pharmacokinetics and Tissue Distribution after Intravenous, Oral, Hypodermic and Sublingual Administration in Rats and Beagle Dogs: Integration of In Vitro and In Vivo Findings
by: Jie Li, et al.
Published: (2017-06-01)

Gankyrin: At the crossroads of cancer diagnosis, disease prognosis, and development of efficient cancer therapeutics
by: Dharmendra Kashyap, et al.
Published: (2022-07-01)

The p16 Antagonist Gankyrin Is Overexpressed in Melanocytic Neoplasms
by: Sara Moradi, et al.
Published: (2022-11-01)

Pharmacokinetics of Arctigenin and Fructus Arctii Powder in Piglets
by: Bin He, et al.
Published: (2019-07-01)

Biodistribution of arctigenin-loaded nanoparticles designed for multimodal imaging
by: Qingxin Cui, et al.
Published: (2017-04-01)

Arctigenin, a Potential Anti-Arrhythmic Agent, Inhibits Aconitine-Induced Arrhythmia by Regulating Multi-Ion Channels
by: Zhenying Zhao, et al.
Published: (2013-11-01)

Arctigenin Inhibits Lung Metastasis of Colorectal Cancer by Regulating Cell Viability and Metastatic Phenotypes
by: Yo-Han Han, et al.
Published: (2016-08-01)

Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation
by: Heng Li, et al.
Published: (2021-11-01)

Arctigenin inhibits prostate tumor cell growth in vitro and in vivo
by: Piwen Wang, et al.
Published: (2017-06-01)

Arctigenin Attenuates Ischemia/Reperfusion Induced Ventricular Arrhythmias by Decreasing Oxidative Stress in Rats
by: Jing Yang, et al.
Published: (2018-08-01)

Additive renal protective effects between arctigenin and puerarin in diabetic kidney disease
by: Xueling Li, et al.
Published: (2024-02-01)

Quantitative Proteomic Analysis Reveals That Arctigenin Alleviates Concanavalin A-Induced Hepatitis Through Suppressing Immune System and Regulating Autophagy
by: Qin Feng, et al.
Published: (2018-08-01)

Arctigenin hinders the invasion and metastasis of cervical cancer cells via the FAK/paxillin pathway
by: Dan Liao, et al.
Published: (2023-06-01)

Expression of Oncoprotein Gankyrin in Drug Resistant and Sensitive Cancer Ovarian and Gastric Cancer Cell Lines
by: Maryam Taheri, et al.
Published: (2018-06-01)

Optimisation of the Conversion and Extraction of Arctigenin From Fructus arctii Into Arctiin Using Fungi
by: Zheng Lu, et al.
Published: (2021-05-01)

Arctigenin: pharmacology, total synthesis, and progress in structure modification
by: Dan Wu, et al.
Published: (2022-12-01)

Chronic Microcystin-LR Exposure Induces Hepatocarcinogenesis via Increased Gankyrin in Vitro and in Vivo
by: Lixiong He, et al.
Published: (2018-09-01)

Deficiency of Gankyrin in the small intestine is associated with augmented colitis accompanied by altered bacterial composition of intestinal microbiota
by: Toshiharu Sakurai, et al.
Published: (2020-01-01)

The oncogene Gankyrin is expressed in testicular cancer and contributes to cisplatin sensitivity in embryonal carcinoma cells
by: Maria E. Camacho-Moll, et al.
Published: (2019-11-01)

Synthesis and Anti-Proliferative Evaluation of Arctigenin Analogues with C-9′ Derivatisation
by: Emily K. Paulin, et al.
Published: (2023-01-01)

Arctigenin Induces an Activation Response in Porcine Alveolar Macrophage Through TLR6-NOX2-MAPKs Signaling Pathway
by: Zheng Lu, et al.
Published: (2018-05-01)

Arctigenin Attenuates Breast Cancer Progression through Decreasing GM-CSF/TSLP/STAT3/β-Catenin Signaling
by: Hui Shi, et al.
Published: (2020-09-01)

Neuroprotective Effect of Arctigenin via Upregulation of P-CREB in Mouse Primary Neurons and Human SH-SY5Y Neuroblastoma Cells
by: Tingguo Kang, et al.
Published: (2013-09-01)

Proteome interrogation using gold nanoprobes to identify targets of arctigenin in fish parasites
by: Xiao Tu, et al.
Published: (2020-02-01)

Second Generation Small Molecule Inhibitors of Gankyrin for the Treatment of Pediatric Liver Cancer
by: Amber M. D’Souza, et al.
Published: (2022-06-01)

Helicobacter pylori infected gastric epithelial cells bypass cell death pathway through the oncoprotein Gankyrin
by: Dharmendra Kashyap, et al.
Published: (2023-07-01)

Hypoxia inhibits osteoclast differentiation by HIF-1α-mediated upregulation of NRP-1
by: LI Songtao, et al.
Published: (2019-06-01)

Gankyrin-mediated interaction between cancer cells and tumor-associated macrophages facilitates prostate cancer progression and androgen deprivation therapy resistance
by: Guang Peng, et al.
Published: (2023-12-01)

α-Mangostin Induces Apoptosis and Inhibits Metastasis of Breast Cancer Cells via Regulating RXRα-AKT Signaling Pathway
by: Xiuzhi Zhu, et al.
Published: (2021-08-01)

Arctigenin Attenuates Tumor Metastasis Through Inhibiting Epithelial–Mesenchymal Transition in Hepatocellular Carcinoma via Suppressing GSK3β-Dependent Wnt/β-Catenin Signaling Pathway In Vivo and In Vitro
by: Zheng Lu, et al.
Published: (2019-08-01)

Norditerpenoids from Flickingeria fimbriata and Their Inhibitory Activities on Nitric Oxide and Tumor Necrosis Factor-α Production in Mouse Macrophages
by: Jin-Long Chen, et al.
Published: (2014-05-01)

Ligand Binding Affinities of Arctigenin and Its Demethylated Metabolites to Estrogen Receptor Alpha
by: Masao Hattori, et al.
Published: (2013-01-01)

Ginsenoside Re Treatment Attenuates Myocardial Hypoxia/Reoxygenation Injury by Inhibiting HIF-1α Ubiquitination
by: Huiyuan Sun, et al.
Published: (2020-09-01)

Arctigenin Enhances the Cytotoxic Effect of Doxorubicin in MDA-MB-231 Breast Cancer Cells
by: Kyu-Shik Lee, et al.
Published: (2020-04-01)

Inhibition of α-Synuclein Aggregation by the Interaction Between Protein Disulfide Isomerase and α-Synuclein
by: PEI Yun-shan1,2, ZHANG Cai1,2, LIU Xiao-li1, CHENG Kai1, ZHANG Ze-ting,1, LI Cong-gang1
Published: (2022-12-01)

Effects of dibenzylbutyrolactone lignans arctigenin and trachelogenin on the motility of isolated rat ileum
by: Peter Kiplang’at Koech, et al.
Published: (2022-01-01)

Targeted Delivery of Arctigenin Using Sialic Acid Conjugate-Modified Liposomes for the Treatment of Breast Cancer
by: Shunfang Liu, et al.
Published: (2024-01-01)

Metabotropic glutamate receptor 5 inhibits α-synuclein-induced microglia inflammation to protect from neurotoxicity in Parkinson’s disease
by: Ya-Nan Zhang, et al.
Published: (2021-01-01)