Characterization of Ciprofloxacin-Bismuth-Loaded Antibacterial Wound Dressing
The research was focused on developing a potentially antibacterial wound dressing made of polyurethane foam and loaded with bismuth-ciprofloxacin (Cip-Bi). The Cip-Bi chemical structure was confirmed by Fourier transform infrared spectroscopic (FTIR) analysis. The sought after antibacterial wound dr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/21/5096 |
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| author | Dorota Kowalczuk Małgorzata Miazga-Karska Agata Gładysz Paweł Warda Agnieszka Barańska Bartłomiej Drop |
| author_facet | Dorota Kowalczuk Małgorzata Miazga-Karska Agata Gładysz Paweł Warda Agnieszka Barańska Bartłomiej Drop |
| author_sort | Dorota Kowalczuk |
| collection | DOAJ |
| description | The research was focused on developing a potentially antibacterial wound dressing made of polyurethane foam and loaded with bismuth-ciprofloxacin (Cip-Bi). The Cip-Bi chemical structure was confirmed by Fourier transform infrared spectroscopic (FTIR) analysis. The sought after antibacterial wound dressing was obtained by modification of the raw dressing with an iodine or bromine solution and subsequently with a Cip-Bi hydrogel. The amount of Cip-Bi loaded into the dressing matrix was determined indirectly on the basis of the differences in Cip-Bi concentrations, before and after the modification process, and the determination was performed with the HPLC (high-performance liquid chromatography) method. The modified dressing was found to have a two-step release of Cip-Bi, a feature helpful in the treatment of locally infected wounds and prevention of secondary bacterial infection. The zone of inhibition test against the selected Gram-positive and Gram-negative bacteria confirmed the antibacterial activity of the Cip-Bi-modified dressing. Preliminary tests conducted so far have been indicative of the Cip-Bi dressing’s relatively high activity against the tested organisms. |
| first_indexed | 2024-03-10T15:08:00Z |
| format | Article |
| id | doaj.art-62894bbd036343c4aee96d6bbbb4bd38 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T15:08:00Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-62894bbd036343c4aee96d6bbbb4bd382023-11-20T19:35:40ZengMDPI AGMolecules1420-30492020-11-012521509610.3390/molecules25215096Characterization of Ciprofloxacin-Bismuth-Loaded Antibacterial Wound DressingDorota Kowalczuk0Małgorzata Miazga-Karska1Agata Gładysz2Paweł Warda3Agnieszka Barańska4Bartłomiej Drop5Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, 20-090 Lublin, PolandDepartment of Biochemistry and Biotechnology, Faculty of Pharmacy, Medical University of Lublin, 20-090 Lublin, PolandDepartment of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, 20-090 Lublin, PolandDepartment of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, 20-090 Lublin, PolandDepartment of Informatics and Medical Statistics, Medical University of Lublin, 20-090 Lublin, PolandDepartment of Informatics and Medical Statistics, Medical University of Lublin, 20-090 Lublin, PolandThe research was focused on developing a potentially antibacterial wound dressing made of polyurethane foam and loaded with bismuth-ciprofloxacin (Cip-Bi). The Cip-Bi chemical structure was confirmed by Fourier transform infrared spectroscopic (FTIR) analysis. The sought after antibacterial wound dressing was obtained by modification of the raw dressing with an iodine or bromine solution and subsequently with a Cip-Bi hydrogel. The amount of Cip-Bi loaded into the dressing matrix was determined indirectly on the basis of the differences in Cip-Bi concentrations, before and after the modification process, and the determination was performed with the HPLC (high-performance liquid chromatography) method. The modified dressing was found to have a two-step release of Cip-Bi, a feature helpful in the treatment of locally infected wounds and prevention of secondary bacterial infection. The zone of inhibition test against the selected Gram-positive and Gram-negative bacteria confirmed the antibacterial activity of the Cip-Bi-modified dressing. Preliminary tests conducted so far have been indicative of the Cip-Bi dressing’s relatively high activity against the tested organisms.https://www.mdpi.com/1420-3049/25/21/5096ciprofloxacin-bismuth complexantimicrobial dressingantimicrobial deliverywound dressingwound infection |
| spellingShingle | Dorota Kowalczuk Małgorzata Miazga-Karska Agata Gładysz Paweł Warda Agnieszka Barańska Bartłomiej Drop Characterization of Ciprofloxacin-Bismuth-Loaded Antibacterial Wound Dressing Molecules ciprofloxacin-bismuth complex antimicrobial dressing antimicrobial delivery wound dressing wound infection |
| title | Characterization of Ciprofloxacin-Bismuth-Loaded Antibacterial Wound Dressing |
| title_full | Characterization of Ciprofloxacin-Bismuth-Loaded Antibacterial Wound Dressing |
| title_fullStr | Characterization of Ciprofloxacin-Bismuth-Loaded Antibacterial Wound Dressing |
| title_full_unstemmed | Characterization of Ciprofloxacin-Bismuth-Loaded Antibacterial Wound Dressing |
| title_short | Characterization of Ciprofloxacin-Bismuth-Loaded Antibacterial Wound Dressing |
| title_sort | characterization of ciprofloxacin bismuth loaded antibacterial wound dressing |
| topic | ciprofloxacin-bismuth complex antimicrobial dressing antimicrobial delivery wound dressing wound infection |
| url | https://www.mdpi.com/1420-3049/25/21/5096 |
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