Dietary branched-chain amino acids get to the heart of H3K23Pr
Cardiac metabolism provides effects that extend beyond the transformation of energy for the heart to operate effectively. Some metabolites also function as signaling molecules and exert transcriptional changes. Heart failure is a progressive pathology in which these metabolite functions falter. In t...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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American Society for Clinical Investigation
2023-11-01
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| Series: | The Journal of Clinical Investigation |
| Online Access: | https://doi.org/10.1172/JCI174953 |
| _version_ | 1827768109820280832 |
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| author | Christina Demetriadou Daniel S. Kantner Nathaniel W. Snyder |
| author_facet | Christina Demetriadou Daniel S. Kantner Nathaniel W. Snyder |
| author_sort | Christina Demetriadou |
| collection | DOAJ |
| description | Cardiac metabolism provides effects that extend beyond the transformation of energy for the heart to operate effectively. Some metabolites also function as signaling molecules and exert transcriptional changes. Heart failure is a progressive pathology in which these metabolite functions falter. In this issue of the JCI, Yang et al. describe a protective effect from a low–branched chain amino acid (BCAA) diet in a mouse model of heart failure. The findings implicate a propionylation mark on histone H3 lysine 23 (H3K23Pr), previously shown to be dependent on the BCAA isoleucine, in transcriptional control of the cardiac stress response. The result underscores the interplay between metabolism and histone acylation, highlighting targeted dietary and pharmacological intervention as a means to decelerate cardiac hypertrophy. |
| first_indexed | 2024-03-11T12:07:40Z |
| format | Article |
| id | doaj.art-6289a5edb5a34c94a40a3cfa42848e47 |
| institution | Directory Open Access Journal |
| issn | 1558-8238 |
| language | English |
| last_indexed | 2024-03-11T12:07:40Z |
| publishDate | 2023-11-01 |
| publisher | American Society for Clinical Investigation |
| record_format | Article |
| series | The Journal of Clinical Investigation |
| spelling | doaj.art-6289a5edb5a34c94a40a3cfa42848e472023-11-07T16:21:05ZengAmerican Society for Clinical InvestigationThe Journal of Clinical Investigation1558-82382023-11-0113322Dietary branched-chain amino acids get to the heart of H3K23PrChristina DemetriadouDaniel S. KantnerNathaniel W. SnyderCardiac metabolism provides effects that extend beyond the transformation of energy for the heart to operate effectively. Some metabolites also function as signaling molecules and exert transcriptional changes. Heart failure is a progressive pathology in which these metabolite functions falter. In this issue of the JCI, Yang et al. describe a protective effect from a low–branched chain amino acid (BCAA) diet in a mouse model of heart failure. The findings implicate a propionylation mark on histone H3 lysine 23 (H3K23Pr), previously shown to be dependent on the BCAA isoleucine, in transcriptional control of the cardiac stress response. The result underscores the interplay between metabolism and histone acylation, highlighting targeted dietary and pharmacological intervention as a means to decelerate cardiac hypertrophy.https://doi.org/10.1172/JCI174953 |
| spellingShingle | Christina Demetriadou Daniel S. Kantner Nathaniel W. Snyder Dietary branched-chain amino acids get to the heart of H3K23Pr The Journal of Clinical Investigation |
| title | Dietary branched-chain amino acids get to the heart of H3K23Pr |
| title_full | Dietary branched-chain amino acids get to the heart of H3K23Pr |
| title_fullStr | Dietary branched-chain amino acids get to the heart of H3K23Pr |
| title_full_unstemmed | Dietary branched-chain amino acids get to the heart of H3K23Pr |
| title_short | Dietary branched-chain amino acids get to the heart of H3K23Pr |
| title_sort | dietary branched chain amino acids get to the heart of h3k23pr |
| url | https://doi.org/10.1172/JCI174953 |
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