Blockage of glutamine-dependent anaplerosis affects mTORC1/2 activity and ultimately leads to cellular senescence-like response

Blockage of glutamine-dependent anaplerosis affects mTORC1/2 activity and ultimately leads to cellular senescence-like response

The purpose of study was to explore the role of glutamine-dependent anaplerosis in cell fate determination (proliferation and senescence) and the potential associated mechanism by employing a pharmacological inhibitor of glutamine-dependent anaplerosis, amino-oxyacetate (AOA). Using the WI38 normal...

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Bibliographic Details
Main Authors: Geng-You Liao, Ming-Ting Lee, Jhen-Jia Fan, Pei-Wen Hsiao, Chun-Sheng Lee, Shou-Yi Su, Jiuan-Jiuan Hwang, Ferng-Chun Ke
Format: Article
Language:English
Published: The Company of Biologists 2019-05-01
Series:Biology Open
Subjects:
Amino-oxyacetate
Cellular senescence
Glutamine-dependent anaplerosis
Metabolism
mTORC
p16INK4A
Online Access:http://bio.biologists.org/content/8/5/bio038257

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