Elevated Fasting Plasma Glucose Is Associated With an Increased Risk of MCI: A Community-Based Cross-Sectional Study
BackgroundMild cognitive impairment (MCI) is a transitional state between normal elderly people and dementia, with a higher risk of dementia transition. The primary purpose of the current study was to investigate whether routine blood and blood biochemical markers could be used to predict the onset...
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| Format: | Article |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.739257/full |
| _version_ | 1828977116328230912 |
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| author | Wei Li Wei Li Ling Yue Ling Yue Lin Sun Lin Sun Shifu Xiao Shifu Xiao |
| author_facet | Wei Li Wei Li Ling Yue Ling Yue Lin Sun Lin Sun Shifu Xiao Shifu Xiao |
| author_sort | Wei Li |
| collection | DOAJ |
| description | BackgroundMild cognitive impairment (MCI) is a transitional state between normal elderly people and dementia, with a higher risk of dementia transition. The primary purpose of the current study was to investigate whether routine blood and blood biochemical markers could be used to predict the onset of MCI.MethodsData was obtained from the cohort study on brain health of the elderly in Shanghai. A total of 1015 community elders were included in the current study. Based on clinical evaluation and the scores of Montreal Cognitive Assessment (MoCA), these participants were divided into the MCI (n=444) and cognitively normal groups (n=571). Then we tested their fasting blood routine and blood biochemical indexes, and collected their general demographic data by using a standard questionnaire.ResultsBy using binary logistic regression analysis and the ROC curve, we found that elevated fasting plasma glucose (p=0.025, OR=1.118, OR=1.014-1.233) was a risk factor for MCI.ConclusionsElevated fasting blood glucose may be a risk factor for mild cognitive impairment, but the above conclusions need to be verified by longitudinal studies. |
| first_indexed | 2024-12-14T14:51:27Z |
| format | Article |
| id | doaj.art-628a7a00beea4cfaa718dce77132bbd2 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-14T14:51:27Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-628a7a00beea4cfaa718dce77132bbd22022-12-21T22:57:08ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-11-011210.3389/fendo.2021.739257739257Elevated Fasting Plasma Glucose Is Associated With an Increased Risk of MCI: A Community-Based Cross-Sectional StudyWei Li0Wei Li1Ling Yue2Ling Yue3Lin Sun4Lin Sun5Shifu Xiao6Shifu Xiao7Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaAlzheimer’s Disease and Related Disorders Center, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaAlzheimer’s Disease and Related Disorders Center, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaAlzheimer’s Disease and Related Disorders Center, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaAlzheimer’s Disease and Related Disorders Center, Shanghai Jiao Tong University, Shanghai, ChinaBackgroundMild cognitive impairment (MCI) is a transitional state between normal elderly people and dementia, with a higher risk of dementia transition. The primary purpose of the current study was to investigate whether routine blood and blood biochemical markers could be used to predict the onset of MCI.MethodsData was obtained from the cohort study on brain health of the elderly in Shanghai. A total of 1015 community elders were included in the current study. Based on clinical evaluation and the scores of Montreal Cognitive Assessment (MoCA), these participants were divided into the MCI (n=444) and cognitively normal groups (n=571). Then we tested their fasting blood routine and blood biochemical indexes, and collected their general demographic data by using a standard questionnaire.ResultsBy using binary logistic regression analysis and the ROC curve, we found that elevated fasting plasma glucose (p=0.025, OR=1.118, OR=1.014-1.233) was a risk factor for MCI.ConclusionsElevated fasting blood glucose may be a risk factor for mild cognitive impairment, but the above conclusions need to be verified by longitudinal studies.https://www.frontiersin.org/articles/10.3389/fendo.2021.739257/fullfasting plasma glucoseMCIcross-sectionalelderlyChinese |
| spellingShingle | Wei Li Wei Li Ling Yue Ling Yue Lin Sun Lin Sun Shifu Xiao Shifu Xiao Elevated Fasting Plasma Glucose Is Associated With an Increased Risk of MCI: A Community-Based Cross-Sectional Study Frontiers in Endocrinology fasting plasma glucose MCI cross-sectional elderly Chinese |
| title | Elevated Fasting Plasma Glucose Is Associated With an Increased Risk of MCI: A Community-Based Cross-Sectional Study |
| title_full | Elevated Fasting Plasma Glucose Is Associated With an Increased Risk of MCI: A Community-Based Cross-Sectional Study |
| title_fullStr | Elevated Fasting Plasma Glucose Is Associated With an Increased Risk of MCI: A Community-Based Cross-Sectional Study |
| title_full_unstemmed | Elevated Fasting Plasma Glucose Is Associated With an Increased Risk of MCI: A Community-Based Cross-Sectional Study |
| title_short | Elevated Fasting Plasma Glucose Is Associated With an Increased Risk of MCI: A Community-Based Cross-Sectional Study |
| title_sort | elevated fasting plasma glucose is associated with an increased risk of mci a community based cross sectional study |
| topic | fasting plasma glucose MCI cross-sectional elderly Chinese |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.739257/full |
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