Effect of Annual Influenza Vaccination on the Risk of Lung Cancer Among Patients With Hypertension: A Population-Based Cohort Study in Taiwan
Objectives: Lung cancer is a main contributor to all newly diagnosed cancers worldwide. The chemoprotective effect of the influenza vaccine among patients with hypertension remains unclear.Methods: A total of 37,022 patients with hypertension were retrospectively enrolled from the Taiwan National He...
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Frontiers Media S.A.
2023-10-01
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| Series: | International Journal of Public Health |
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| Online Access: | https://www.ssph-journal.org/articles/10.3389/ijph.2023.1605370/full |
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| author | Hung-Chang Jong Jing-Quan Zheng Jing-Quan Zheng Jing-Quan Zheng Cai-Mei Zheng Cai-Mei Zheng Cai-Mei Zheng Cheng-Hsin Lin Cheng-Hsin Lin Cheng-Hsin Lin Chun-Chih Chiu Chun-Chih Chiu Chun-Chih Chiu Min-Huei Hsu Min-Huei Hsu Yu-Ann Fang Yu-Ann Fang Yu-Ann Fang Wen-Rui Hao Wen-Rui Hao Wen-Rui Hao Chun-Chao Chen Chun-Chao Chen Chun-Chao Chen Chun-Chao Chen Tsung Yeh Yang Tsung Yeh Yang Tsung Yeh Yang Kang-Yun Lee Kang-Yun Lee Kang-Yun Lee Ju-Chi Liu Ju-Chi Liu Ju-Chi Liu |
| author_facet | Hung-Chang Jong Jing-Quan Zheng Jing-Quan Zheng Jing-Quan Zheng Cai-Mei Zheng Cai-Mei Zheng Cai-Mei Zheng Cheng-Hsin Lin Cheng-Hsin Lin Cheng-Hsin Lin Chun-Chih Chiu Chun-Chih Chiu Chun-Chih Chiu Min-Huei Hsu Min-Huei Hsu Yu-Ann Fang Yu-Ann Fang Yu-Ann Fang Wen-Rui Hao Wen-Rui Hao Wen-Rui Hao Chun-Chao Chen Chun-Chao Chen Chun-Chao Chen Chun-Chao Chen Tsung Yeh Yang Tsung Yeh Yang Tsung Yeh Yang Kang-Yun Lee Kang-Yun Lee Kang-Yun Lee Ju-Chi Liu Ju-Chi Liu Ju-Chi Liu |
| author_sort | Hung-Chang Jong |
| collection | DOAJ |
| description | Objectives: Lung cancer is a main contributor to all newly diagnosed cancers worldwide. The chemoprotective effect of the influenza vaccine among patients with hypertension remains unclear.Methods: A total of 37,022 patients with hypertension were retrospectively enrolled from the Taiwan National Health Insurance Research Database. These patients were further divided into a vaccinated group (n = 15,697) and an unvaccinated group (n = 21,325).Results: After adjusting for sex, age, comorbidities, medications, level of urbanization and monthly income, vaccinated patients had a significantly lower risk of lung cancer occurrence than unvaccinated patients (adjusted hazard ratio [aHR]: 0.56, 95% confidence interval [CI]: 0.47–0.67). A potential protective effect was observed for both sexes and in the elderly age group. With a greater total number of vaccinations, a potentially greater protective effect was observed (aHR: 0.75, 95% CI 0.60–0.95; aHR: 0.66, 95% CI: 0.53–0.82; aHR: 0.26, 95% CI: 0.19–0.36, after receiving 1, 2–3 and ≥4 vaccinations, respectively).Conclusion: Influenza vaccination was associated with a lower risk of lung cancer among patients with hypertension. The potentially chemoprotective effect appeared to be dose dependent. |
| first_indexed | 2024-03-11T20:38:19Z |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-03-11T20:38:19Z |
| publishDate | 2023-10-01 |
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| series | International Journal of Public Health |
| spelling | doaj.art-628cf94345ec4c5783acdaf0393817332023-10-02T04:11:24ZengFrontiers Media S.A.International Journal of Public Health1661-85642023-10-016810.3389/ijph.2023.16053701605370Effect of Annual Influenza Vaccination on the Risk of Lung Cancer Among Patients With Hypertension: A Population-Based Cohort Study in TaiwanHung-Chang Jong0Jing-Quan Zheng1Jing-Quan Zheng2Jing-Quan Zheng3Cai-Mei Zheng4Cai-Mei Zheng5Cai-Mei Zheng6Cheng-Hsin Lin7Cheng-Hsin Lin8Cheng-Hsin Lin9Chun-Chih Chiu10Chun-Chih Chiu11Chun-Chih Chiu12Min-Huei Hsu13Min-Huei Hsu14Yu-Ann Fang15Yu-Ann Fang16Yu-Ann Fang17Wen-Rui Hao18Wen-Rui Hao19Wen-Rui Hao20Chun-Chao Chen21Chun-Chao Chen22Chun-Chao Chen23Chun-Chao Chen24Tsung Yeh Yang25Tsung Yeh Yang26Tsung Yeh Yang27Kang-Yun Lee28Kang-Yun Lee29Kang-Yun Lee30Ju-Chi Liu31Ju-Chi Liu32Ju-Chi Liu33Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanDivision of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanDivision of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanDepartment of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanDivision of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanTaipei Medical University Research Center of Urology and Kidney, Taipei Medical University, Taipei, TaiwanTaipei Heart Institute, Taipei Medical University, Taipei, TaiwanDivision of Cardiovascular Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan0Division of Cardiovascular Surgery, Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanDivision of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanTaipei Heart Institute, Taipei Medical University, Taipei, Taiwan1Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan2Graduate Institute of Data Science, College of Management, Taipei Medical University, Taipei, Taiwan3Department of Neurosurgery, Shuang Ho Hospital, Taipei Medical University, Taipei, TaiwanDivision of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanTaipei Heart Institute, Taipei Medical University, Taipei, Taiwan1Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanDivision of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanTaipei Heart Institute, Taipei Medical University, Taipei, Taiwan1Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanDivision of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanTaipei Heart Institute, Taipei Medical University, Taipei, Taiwan1Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan4Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, TaiwanDivision of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanTaipei Heart Institute, Taipei Medical University, Taipei, Taiwan1Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanDivision of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanDivision of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanDivision of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanTaipei Heart Institute, Taipei Medical University, Taipei, Taiwan1Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanObjectives: Lung cancer is a main contributor to all newly diagnosed cancers worldwide. The chemoprotective effect of the influenza vaccine among patients with hypertension remains unclear.Methods: A total of 37,022 patients with hypertension were retrospectively enrolled from the Taiwan National Health Insurance Research Database. These patients were further divided into a vaccinated group (n = 15,697) and an unvaccinated group (n = 21,325).Results: After adjusting for sex, age, comorbidities, medications, level of urbanization and monthly income, vaccinated patients had a significantly lower risk of lung cancer occurrence than unvaccinated patients (adjusted hazard ratio [aHR]: 0.56, 95% confidence interval [CI]: 0.47–0.67). A potential protective effect was observed for both sexes and in the elderly age group. With a greater total number of vaccinations, a potentially greater protective effect was observed (aHR: 0.75, 95% CI 0.60–0.95; aHR: 0.66, 95% CI: 0.53–0.82; aHR: 0.26, 95% CI: 0.19–0.36, after receiving 1, 2–3 and ≥4 vaccinations, respectively).Conclusion: Influenza vaccination was associated with a lower risk of lung cancer among patients with hypertension. The potentially chemoprotective effect appeared to be dose dependent.https://www.ssph-journal.org/articles/10.3389/ijph.2023.1605370/fulllung cancerpreventionhypertensioninfluenza vaccinationmalignancy |
| spellingShingle | Hung-Chang Jong Jing-Quan Zheng Jing-Quan Zheng Jing-Quan Zheng Cai-Mei Zheng Cai-Mei Zheng Cai-Mei Zheng Cheng-Hsin Lin Cheng-Hsin Lin Cheng-Hsin Lin Chun-Chih Chiu Chun-Chih Chiu Chun-Chih Chiu Min-Huei Hsu Min-Huei Hsu Yu-Ann Fang Yu-Ann Fang Yu-Ann Fang Wen-Rui Hao Wen-Rui Hao Wen-Rui Hao Chun-Chao Chen Chun-Chao Chen Chun-Chao Chen Chun-Chao Chen Tsung Yeh Yang Tsung Yeh Yang Tsung Yeh Yang Kang-Yun Lee Kang-Yun Lee Kang-Yun Lee Ju-Chi Liu Ju-Chi Liu Ju-Chi Liu Effect of Annual Influenza Vaccination on the Risk of Lung Cancer Among Patients With Hypertension: A Population-Based Cohort Study in Taiwan International Journal of Public Health lung cancer prevention hypertension influenza vaccination malignancy |
| title | Effect of Annual Influenza Vaccination on the Risk of Lung Cancer Among Patients With Hypertension: A Population-Based Cohort Study in Taiwan |
| title_full | Effect of Annual Influenza Vaccination on the Risk of Lung Cancer Among Patients With Hypertension: A Population-Based Cohort Study in Taiwan |
| title_fullStr | Effect of Annual Influenza Vaccination on the Risk of Lung Cancer Among Patients With Hypertension: A Population-Based Cohort Study in Taiwan |
| title_full_unstemmed | Effect of Annual Influenza Vaccination on the Risk of Lung Cancer Among Patients With Hypertension: A Population-Based Cohort Study in Taiwan |
| title_short | Effect of Annual Influenza Vaccination on the Risk of Lung Cancer Among Patients With Hypertension: A Population-Based Cohort Study in Taiwan |
| title_sort | effect of annual influenza vaccination on the risk of lung cancer among patients with hypertension a population based cohort study in taiwan |
| topic | lung cancer prevention hypertension influenza vaccination malignancy |
| url | https://www.ssph-journal.org/articles/10.3389/ijph.2023.1605370/full |
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