Progression of valve heart disease in a cohort of patients undergoing renal replacement therapy
Abstract Introduction: Cardiovascular disease is an important cause of death among patients with chronic kidney disease (CKD). Valve calcification is a predictor of cardiovascular mortality and coronary artery disease. Objective: To assess heart valve disease frequency, associated factors, and pro...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Nefrologia
2023-11-01
|
| Series: | Brazilian Journal of Nephrology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002023005042501&tlng=pt |
| _version_ | 1797628715689050112 |
|---|---|
| author | Maria Eduarda Cavalcanti Tompson José Arthur Viana de Oliveira Pimentel Manuella de Amorim Silva Marcelo Antônio Oliveira Santos-Veloso Andrea Bezerra de Melo da Silveira Lordsleem Sandro Gonçalves de Lima |
| author_facet | Maria Eduarda Cavalcanti Tompson José Arthur Viana de Oliveira Pimentel Manuella de Amorim Silva Marcelo Antônio Oliveira Santos-Veloso Andrea Bezerra de Melo da Silveira Lordsleem Sandro Gonçalves de Lima |
| author_sort | Maria Eduarda Cavalcanti Tompson |
| collection | DOAJ |
| description | Abstract Introduction: Cardiovascular disease is an important cause of death among patients with chronic kidney disease (CKD). Valve calcification is a predictor of cardiovascular mortality and coronary artery disease. Objective: To assess heart valve disease frequency, associated factors, and progression in CKD patients. Methods: We conducted a retrospective study on 291 CKD patients at Hospital das Clínicas de Pernambuco. Inclusion criteria were age ≥ 18 with CKD and valve disease, while those on conservative management or with missing data were excluded. Clinical and laboratory variables were compared, and patients were categorized by dialysis duration (<5 years; 5–10 years; >10 years). Statistical tests, including chi-square, Fisher’s exact, ANOVA, and Kruskal-Wallis, were employed as needed. Simple and multivariate binary regression models were used to analyze valve disease associations with dialysis duration. Significance was defined as p < 0.05. Results: Mitral valve disease was present in 82.5% (240) of patients, followed by aortic valve disease (65.6%; 86). Over time, 106 (36.4%) patients developed valve disease. No significant association was found between aortic, pulmonary, mitral, or tricuspid valve disease and dialysis duration. Secondary hyperparathyroidism was the sole statistically significant factor for mitral valve disease in the regression model (OR 2.59 [95% CI: 1.09–6.18]; p = 0.031). Conclusion: CKD patients on renal replacement therapy exhibit a high frequency of valve disease, particularly mitral and aortic valve disease. However, no link was established between dialysis duration and valve disease occurrence or progression. |
| first_indexed | 2024-03-11T10:44:00Z |
| format | Article |
| id | doaj.art-628e6be3f5ea415286c07ed1e45a26cb |
| institution | Directory Open Access Journal |
| issn | 2175-8239 |
| language | English |
| last_indexed | 2024-03-11T10:44:00Z |
| publishDate | 2023-11-01 |
| publisher | Sociedade Brasileira de Nefrologia |
| record_format | Article |
| series | Brazilian Journal of Nephrology |
| spelling | doaj.art-628e6be3f5ea415286c07ed1e45a26cb2023-11-14T07:51:32ZengSociedade Brasileira de NefrologiaBrazilian Journal of Nephrology2175-82392023-11-0110.1590/2175-8239-jbn-2023-0036enProgression of valve heart disease in a cohort of patients undergoing renal replacement therapyMaria Eduarda Cavalcanti Tompsonhttps://orcid.org/0000-0001-5655-0448José Arthur Viana de Oliveira Pimentelhttps://orcid.org/0000-0003-0400-532XManuella de Amorim Silvahttps://orcid.org/0000-0001-5488-9843Marcelo Antônio Oliveira Santos-Velosohttps://orcid.org/0000-0001-6025-9821Andrea Bezerra de Melo da Silveira Lordsleemhttps://orcid.org/0000-0001-8212-0169Sandro Gonçalves de Limahttps://orcid.org/0000-0003-1088-2126Abstract Introduction: Cardiovascular disease is an important cause of death among patients with chronic kidney disease (CKD). Valve calcification is a predictor of cardiovascular mortality and coronary artery disease. Objective: To assess heart valve disease frequency, associated factors, and progression in CKD patients. Methods: We conducted a retrospective study on 291 CKD patients at Hospital das Clínicas de Pernambuco. Inclusion criteria were age ≥ 18 with CKD and valve disease, while those on conservative management or with missing data were excluded. Clinical and laboratory variables were compared, and patients were categorized by dialysis duration (<5 years; 5–10 years; >10 years). Statistical tests, including chi-square, Fisher’s exact, ANOVA, and Kruskal-Wallis, were employed as needed. Simple and multivariate binary regression models were used to analyze valve disease associations with dialysis duration. Significance was defined as p < 0.05. Results: Mitral valve disease was present in 82.5% (240) of patients, followed by aortic valve disease (65.6%; 86). Over time, 106 (36.4%) patients developed valve disease. No significant association was found between aortic, pulmonary, mitral, or tricuspid valve disease and dialysis duration. Secondary hyperparathyroidism was the sole statistically significant factor for mitral valve disease in the regression model (OR 2.59 [95% CI: 1.09–6.18]; p = 0.031). Conclusion: CKD patients on renal replacement therapy exhibit a high frequency of valve disease, particularly mitral and aortic valve disease. However, no link was established between dialysis duration and valve disease occurrence or progression.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002023005042501&tlng=ptHeart Valve DiseasesChronic Kidney FailureCalcification |
| spellingShingle | Maria Eduarda Cavalcanti Tompson José Arthur Viana de Oliveira Pimentel Manuella de Amorim Silva Marcelo Antônio Oliveira Santos-Veloso Andrea Bezerra de Melo da Silveira Lordsleem Sandro Gonçalves de Lima Progression of valve heart disease in a cohort of patients undergoing renal replacement therapy Brazilian Journal of Nephrology Heart Valve Diseases Chronic Kidney Failure Calcification |
| title | Progression of valve heart disease in a cohort of patients undergoing renal replacement therapy |
| title_full | Progression of valve heart disease in a cohort of patients undergoing renal replacement therapy |
| title_fullStr | Progression of valve heart disease in a cohort of patients undergoing renal replacement therapy |
| title_full_unstemmed | Progression of valve heart disease in a cohort of patients undergoing renal replacement therapy |
| title_short | Progression of valve heart disease in a cohort of patients undergoing renal replacement therapy |
| title_sort | progression of valve heart disease in a cohort of patients undergoing renal replacement therapy |
| topic | Heart Valve Diseases Chronic Kidney Failure Calcification |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002023005042501&tlng=pt |
| work_keys_str_mv | AT mariaeduardacavalcantitompson progressionofvalveheartdiseaseinacohortofpatientsundergoingrenalreplacementtherapy AT josearthurvianadeoliveirapimentel progressionofvalveheartdiseaseinacohortofpatientsundergoingrenalreplacementtherapy AT manuelladeamorimsilva progressionofvalveheartdiseaseinacohortofpatientsundergoingrenalreplacementtherapy AT marceloantoniooliveirasantosveloso progressionofvalveheartdiseaseinacohortofpatientsundergoingrenalreplacementtherapy AT andreabezerrademelodasilveiralordsleem progressionofvalveheartdiseaseinacohortofpatientsundergoingrenalreplacementtherapy AT sandrogoncalvesdelima progressionofvalveheartdiseaseinacohortofpatientsundergoingrenalreplacementtherapy |