β-Adrenoceptors Trigger Melatonin Synthesis in Phagocytes

β-Adrenoceptors Trigger Melatonin Synthesis in Phagocytes

Melatonin (5-methoxy-N-acetylserotonin), the pineal hormone, is also synthesized by immune-competent cells. The pineal hormone signals darkness, while melatonin synthesized on demand by activated macrophages at any hour of the day acts locally, favoring regulatory/tolerant phenotypes. Activation of...

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Bibliographic Details
Main Authors: Marco A. Pires-Lapa, Claudia E. Carvalho-Sousa, Erika Cecon, Pedro A. Fernandes, Regina P. Markus
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
melatonin
macrophages
beta-adrenergic receptors
immune-pineal axis
nuclear factor kappa B (NF-κB)
extra-pineal melatonin synthesis
Online Access:http://www.mdpi.com/1422-0067/19/8/2182

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