Effect of trazodone on sleep bruxism in children and adolescents 6-18 years of age, a pilot study
<ul> <li><strong>BACKGROUND</strong>: Sleep bruxism is a common sleep disorder with unclear etiology and no definitive treatment. Recent</li> <li>suggested medications are not often practically used due to their nume...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2008-02-01
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| Series: | Journal of Research in Medical Sciences |
| Subjects: | |
| Online Access: | http://journals.mui.ac.ir/jrms/article/view/1127 |
| _version_ | 1811247504081027072 |
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| author | Fereshteh Shakibaei Ali Gholamrezaei Shahram Heidari |
| author_facet | Fereshteh Shakibaei Ali Gholamrezaei Shahram Heidari |
| author_sort | Fereshteh Shakibaei |
| collection | DOAJ |
| description | <ul> <li><strong>BACKGROUND</strong>: Sleep bruxism is a common sleep disorder with unclear etiology and no definitive treatment. Recent</li> <li>suggested medications are not often practically used due to their numerous limitations. Based on the fact that sleep bruxism occurs most often in the second stage of non-REM sleep, this study aimed to assess the effect of trazodone on sleep bruxism.<strong> <br /> </strong></li> <li><strong>METHODS</strong>: This pilot study was conducted as a before-after design on 28 children and adolescents with 6-18 years of age suffering from sleep bruxism referring by children and adolescents mental health clinic, children dental specialists and pediatricians. The treatment started with 0.5mg/kg/day. In non-responders, it was weekly added by 0.5 mg/kg/day (with optimum of 2 mg/kg/day). Frequency of bruxism and related morning face/jaw pain were assessed daily from two weeks before (baseline) to four weeks after starting the intervention by the parents/roommate.</li> <li><strong>RESULTS</strong>: Findings showed a significant reduction in the frequency of both bruxism and related morning pain from baseline to the 2nd and the 4th weeks of the intervention (P&lt;0.001). Minor side effects such as drowsiness, nausea and dry mouth were seen among approximately one-third of the patients. These side effects were self-limited and tolerable.</li> <li><strong>CONCLUSIONS: </strong>Trazodone could be effective in reducing the frequency of sleep bruxism and its related morning face/jaw pain. Well-designed placebo-controlled trials are needed to confirm the results.</li> <li><strong>KEY WORDS</strong>: Sleep bruxism, trazodone, teeth clenching, teeth grinding.</li> </ul> |
| first_indexed | 2024-04-12T15:10:54Z |
| format | Article |
| id | doaj.art-62906959dfec4cb1bee96df9da5d1008 |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-04-12T15:10:54Z |
| publishDate | 2008-02-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-62906959dfec4cb1bee96df9da5d10082022-12-22T03:27:47ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362008-02-011312933Effect of trazodone on sleep bruxism in children and adolescents 6-18 years of age, a pilot studyFereshteh ShakibaeiAli GholamrezaeiShahram Heidari<ul> <li><strong>BACKGROUND</strong>: Sleep bruxism is a common sleep disorder with unclear etiology and no definitive treatment. Recent</li> <li>suggested medications are not often practically used due to their numerous limitations. Based on the fact that sleep bruxism occurs most often in the second stage of non-REM sleep, this study aimed to assess the effect of trazodone on sleep bruxism.<strong> <br /> </strong></li> <li><strong>METHODS</strong>: This pilot study was conducted as a before-after design on 28 children and adolescents with 6-18 years of age suffering from sleep bruxism referring by children and adolescents mental health clinic, children dental specialists and pediatricians. The treatment started with 0.5mg/kg/day. In non-responders, it was weekly added by 0.5 mg/kg/day (with optimum of 2 mg/kg/day). Frequency of bruxism and related morning face/jaw pain were assessed daily from two weeks before (baseline) to four weeks after starting the intervention by the parents/roommate.</li> <li><strong>RESULTS</strong>: Findings showed a significant reduction in the frequency of both bruxism and related morning pain from baseline to the 2nd and the 4th weeks of the intervention (P&lt;0.001). Minor side effects such as drowsiness, nausea and dry mouth were seen among approximately one-third of the patients. These side effects were self-limited and tolerable.</li> <li><strong>CONCLUSIONS: </strong>Trazodone could be effective in reducing the frequency of sleep bruxism and its related morning face/jaw pain. Well-designed placebo-controlled trials are needed to confirm the results.</li> <li><strong>KEY WORDS</strong>: Sleep bruxism, trazodone, teeth clenching, teeth grinding.</li> </ul>http://journals.mui.ac.ir/jrms/article/view/1127Sleep bruxism, trazodone, teeth clenching, teeth grinding. |
| spellingShingle | Fereshteh Shakibaei Ali Gholamrezaei Shahram Heidari Effect of trazodone on sleep bruxism in children and adolescents 6-18 years of age, a pilot study Journal of Research in Medical Sciences Sleep bruxism, trazodone, teeth clenching, teeth grinding. |
| title | Effect of trazodone on sleep bruxism in children and adolescents 6-18 years of age, a pilot study |
| title_full | Effect of trazodone on sleep bruxism in children and adolescents 6-18 years of age, a pilot study |
| title_fullStr | Effect of trazodone on sleep bruxism in children and adolescents 6-18 years of age, a pilot study |
| title_full_unstemmed | Effect of trazodone on sleep bruxism in children and adolescents 6-18 years of age, a pilot study |
| title_short | Effect of trazodone on sleep bruxism in children and adolescents 6-18 years of age, a pilot study |
| title_sort | effect of trazodone on sleep bruxism in children and adolescents 6 18 years of age a pilot study |
| topic | Sleep bruxism, trazodone, teeth clenching, teeth grinding. |
| url | http://journals.mui.ac.ir/jrms/article/view/1127 |
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