Design, Synthesis, In Silico Studies and In Vitro Evaluation of New Indole- and/or Donepezil-like Hybrids as Multitarget-Directed Agents for Alzheimer’s Disease

Design, Synthesis, In Silico Studies and In Vitro Evaluation of New Indole- and/or Donepezil-like Hybrids as Multitarget-Directed Agents for Alzheimer’s Disease

Alzheimer’s disease (AD) is considered a complex neurodegenerative condition which warrants the development of multitargeted drugs to tackle the key pathogenetic mechanisms of the disease. In this study, two novel series of melatonin- and donepezil-based hybrid molecules with hydrazone (<b>3a–...

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Bibliographic Details
Main Authors: Violina T. Angelova, Borislav Georgiev, Tania Pencheva, Ilza Pajeva, Miroslav Rangelov, Nadezhda Todorova, Dimitrina Zheleva-Dimitrova, Elena Kalcheva-Yovkova, Iva V. Valkova, Nikolay Vassilev, Rositsa Mihaylova, Denitsa Stefanova, Boris Petrov, Yulian Voynikov, Virginia Tzankova
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Pharmaceuticals
Subjects:
AChE/BChE
Alzheimer’s disease
neurodegenerative disorders
antioxidants
donepezil
melatonin
Online Access:https://www.mdpi.com/1424-8247/16/9/1194

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