Collagen IV (COL4A1, COL4A2), a Component of the Viral Biofilm, Is Induced by the HTLV-1 Oncoprotein Tax and Impacts Virus Transmission

Collagen IV (COL4A1, COL4A2), a Component of the Viral Biofilm, Is Induced by the HTLV-1 Oncoprotein Tax and Impacts Virus Transmission

Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent for Adult T-Cell Leukemia/Lymphoma (ATLL) and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). HTLV-1 infects CD4+ T-cells via cell-to-cell transmission requiring reorganization of the cytoskeleton and expression...

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Bibliographic Details
Main Authors: Sebastian Millen, Christine Gross, Norbert Donhauser, Melanie C. Mann, Jean-Marie Péloponèse Jr., Andrea K. Thoma-Kress
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Microbiology
Subjects:
HTLV-1
Tax-1
collagen 4
collagen IV
COL4A1
COL4A2
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.02439/full

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