Analysis of post COVID-19 condition and its overlap with myalgic encephalomyelitis/chronic fatigue syndrome
Background: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) disease (COVID-19) triggers the development of numerous pathologies and infection-linked complications and exacerbates existing pathologies in nearly all body systems. Aside from the primarily targeted respiratory organs, a...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-09-01
|
| Series: | Journal of Advanced Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123221002320 |
| _version_ | 1818065472636059648 |
|---|---|
| author | Olga A. Sukocheva Rebekah Maksoud Narasimha M. Beeraka SabbaRao V. Madhunapantula Mikhail Sinelnikov Vladimir N. Nikolenko Margarita E. Neganova Sergey G. Klochkov Mohammad Amjad Kamal Donald R Staines Sonya Marshall-Gradisnik |
| author_facet | Olga A. Sukocheva Rebekah Maksoud Narasimha M. Beeraka SabbaRao V. Madhunapantula Mikhail Sinelnikov Vladimir N. Nikolenko Margarita E. Neganova Sergey G. Klochkov Mohammad Amjad Kamal Donald R Staines Sonya Marshall-Gradisnik |
| author_sort | Olga A. Sukocheva |
| collection | DOAJ |
| description | Background: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) disease (COVID-19) triggers the development of numerous pathologies and infection-linked complications and exacerbates existing pathologies in nearly all body systems. Aside from the primarily targeted respiratory organs, adverse SARS-CoV-2 effects were observed in nervous, cardiovascular, gastrointestinal/metabolic, immune, and other systems in COVID-19 survivors. Long-term effects of this viral infection have been recently observed and represent distressing sequelae recognised by the World Health Organisation (WHO) as a distinct clinical entity defined as post-COVID-19 condition. Considering the pandemic is still ongoing, more time is required to confirm post COVID-19 condition diagnosis in the COVID-19 infected cohorts, although many reported post COVID-19 symptoms overlap with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Aims of Review: In this study, COVID-19 clinical presentation and associated post-infection sequelae (post-COVID-19 condition) were reviewed and compared with ME/CFS symptomatology. Key Scientific Concepts of Review: The onset, progression, and symptom profile of post COVID-19 condition patients have considerable overlap with ME/CFS. Considering the large scope and range of pro-inflammatory effects of this virus, it is reasonable to expect development of post COVID-19 clinical complications in a proportion of the affected population. There are reports of a later debilitating syndrome onset three months post COVID-19 infection (often described as long-COVID-19), marked by the presence of fatigue, headache, cognitive dysfunction, post-exertional malaise, orthostatic intolerance, and dyspnoea. Acute inflammation, oxidative stress, and increased levels of interleukin-6 (IL-6) and tumor necrosis factor α (TNFα), have been reported in SARS-CoV-2 infected patients. Longitudinal monitoring of post COVID-19 patients is warranted to understand the long-term effects of SARS-CoV-2 infection and the pathomechanism of post COVID-19 condition. |
| first_indexed | 2024-12-10T14:52:26Z |
| format | Article |
| id | doaj.art-62921c424b174f15a2ac0c97d323bccb |
| institution | Directory Open Access Journal |
| issn | 2090-1232 |
| language | English |
| last_indexed | 2024-12-10T14:52:26Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Advanced Research |
| spelling | doaj.art-62921c424b174f15a2ac0c97d323bccb2022-12-22T01:44:25ZengElsevierJournal of Advanced Research2090-12322022-09-0140179196Analysis of post COVID-19 condition and its overlap with myalgic encephalomyelitis/chronic fatigue syndromeOlga A. Sukocheva0Rebekah Maksoud1Narasimha M. Beeraka2SabbaRao V. Madhunapantula3Mikhail Sinelnikov4Vladimir N. Nikolenko5Margarita E. Neganova6Sergey G. Klochkov7Mohammad Amjad Kamal8Donald R Staines9Sonya Marshall-Gradisnik10College of Nursing and Health Sciences, Flinders University of South Australia, Bedford Park 5042, SA, Australia; The National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia; Corresponding author at: College of Nursing and Health Sciences, Flinders University of South Australia, Bedford Park 5042, SA, Australia.The National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia; Consortium Health International for Myalgic Encephalomyelitis, National Centre for Neuroimmunology and Emerging Diseases, Griffith University, Gold Coast, QLD, AustraliaDepartment of Biochemistry, Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR), JSS Academy of Higher Education & Research (JSS AHER), Mysore, IndiaDepartment of Biochemistry, Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR), JSS Academy of Higher Education & Research (JSS AHER), Mysore, India; Special Interest Group in Cancer Biology and Cancer Stem Cells (SIG-CBCSC), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysore, IndiaI.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Mohovaya 11c10, Moscow, RussiaI.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Mohovaya 11c10, Moscow, RussiaInstitute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka 142432, RussiaInstitute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka 142432, RussiaKing Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589, Saudi Arabia; Enzymoics, 7 Peterlee Place, Novel Global Community Educational Foundation, Hebersham, NSW 2770, AustraliaThe National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia; Consortium Health International for Myalgic Encephalomyelitis, National Centre for Neuroimmunology and Emerging Diseases, Griffith University, Gold Coast, QLD, AustraliaThe National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia; Consortium Health International for Myalgic Encephalomyelitis, National Centre for Neuroimmunology and Emerging Diseases, Griffith University, Gold Coast, QLD, AustraliaBackground: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) disease (COVID-19) triggers the development of numerous pathologies and infection-linked complications and exacerbates existing pathologies in nearly all body systems. Aside from the primarily targeted respiratory organs, adverse SARS-CoV-2 effects were observed in nervous, cardiovascular, gastrointestinal/metabolic, immune, and other systems in COVID-19 survivors. Long-term effects of this viral infection have been recently observed and represent distressing sequelae recognised by the World Health Organisation (WHO) as a distinct clinical entity defined as post-COVID-19 condition. Considering the pandemic is still ongoing, more time is required to confirm post COVID-19 condition diagnosis in the COVID-19 infected cohorts, although many reported post COVID-19 symptoms overlap with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Aims of Review: In this study, COVID-19 clinical presentation and associated post-infection sequelae (post-COVID-19 condition) were reviewed and compared with ME/CFS symptomatology. Key Scientific Concepts of Review: The onset, progression, and symptom profile of post COVID-19 condition patients have considerable overlap with ME/CFS. Considering the large scope and range of pro-inflammatory effects of this virus, it is reasonable to expect development of post COVID-19 clinical complications in a proportion of the affected population. There are reports of a later debilitating syndrome onset three months post COVID-19 infection (often described as long-COVID-19), marked by the presence of fatigue, headache, cognitive dysfunction, post-exertional malaise, orthostatic intolerance, and dyspnoea. Acute inflammation, oxidative stress, and increased levels of interleukin-6 (IL-6) and tumor necrosis factor α (TNFα), have been reported in SARS-CoV-2 infected patients. Longitudinal monitoring of post COVID-19 patients is warranted to understand the long-term effects of SARS-CoV-2 infection and the pathomechanism of post COVID-19 condition.http://www.sciencedirect.com/science/article/pii/S2090123221002320CoronavirusFatigueSequelaePost-infectionChronic fatigue syndromeMyalgic encephalomyelitis |
| spellingShingle | Olga A. Sukocheva Rebekah Maksoud Narasimha M. Beeraka SabbaRao V. Madhunapantula Mikhail Sinelnikov Vladimir N. Nikolenko Margarita E. Neganova Sergey G. Klochkov Mohammad Amjad Kamal Donald R Staines Sonya Marshall-Gradisnik Analysis of post COVID-19 condition and its overlap with myalgic encephalomyelitis/chronic fatigue syndrome Journal of Advanced Research Coronavirus Fatigue Sequelae Post-infection Chronic fatigue syndrome Myalgic encephalomyelitis |
| title | Analysis of post COVID-19 condition and its overlap with myalgic encephalomyelitis/chronic fatigue syndrome |
| title_full | Analysis of post COVID-19 condition and its overlap with myalgic encephalomyelitis/chronic fatigue syndrome |
| title_fullStr | Analysis of post COVID-19 condition and its overlap with myalgic encephalomyelitis/chronic fatigue syndrome |
| title_full_unstemmed | Analysis of post COVID-19 condition and its overlap with myalgic encephalomyelitis/chronic fatigue syndrome |
| title_short | Analysis of post COVID-19 condition and its overlap with myalgic encephalomyelitis/chronic fatigue syndrome |
| title_sort | analysis of post covid 19 condition and its overlap with myalgic encephalomyelitis chronic fatigue syndrome |
| topic | Coronavirus Fatigue Sequelae Post-infection Chronic fatigue syndrome Myalgic encephalomyelitis |
| url | http://www.sciencedirect.com/science/article/pii/S2090123221002320 |
| work_keys_str_mv | AT olgaasukocheva analysisofpostcovid19conditionanditsoverlapwithmyalgicencephalomyelitischronicfatiguesyndrome AT rebekahmaksoud analysisofpostcovid19conditionanditsoverlapwithmyalgicencephalomyelitischronicfatiguesyndrome AT narasimhambeeraka analysisofpostcovid19conditionanditsoverlapwithmyalgicencephalomyelitischronicfatiguesyndrome AT sabbaraovmadhunapantula analysisofpostcovid19conditionanditsoverlapwithmyalgicencephalomyelitischronicfatiguesyndrome AT mikhailsinelnikov analysisofpostcovid19conditionanditsoverlapwithmyalgicencephalomyelitischronicfatiguesyndrome AT vladimirnnikolenko analysisofpostcovid19conditionanditsoverlapwithmyalgicencephalomyelitischronicfatiguesyndrome AT margaritaeneganova analysisofpostcovid19conditionanditsoverlapwithmyalgicencephalomyelitischronicfatiguesyndrome AT sergeygklochkov analysisofpostcovid19conditionanditsoverlapwithmyalgicencephalomyelitischronicfatiguesyndrome AT mohammadamjadkamal analysisofpostcovid19conditionanditsoverlapwithmyalgicencephalomyelitischronicfatiguesyndrome AT donaldrstaines analysisofpostcovid19conditionanditsoverlapwithmyalgicencephalomyelitischronicfatiguesyndrome AT sonyamarshallgradisnik analysisofpostcovid19conditionanditsoverlapwithmyalgicencephalomyelitischronicfatiguesyndrome |